Role of Computed Tomography in Predicting Programmed Death Ligand-1 Positivity in Gastric Adenocarcinoma
Zhi-Hong Yu,1,* Wei-Qin Ma,2,* Ji-Wei Ren,3 Xu-Ting Zhang,3 Lin Chu3 1Department of Ultrasound, Shanxi Provincial People’s Hospital, The Fifth Hospital of Shanxi Medical University, The Fifth Clinical Medical College of Shanxi Medical University, Taiyuan, Shanxi, 030012, People’s Rep...
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2025-02-01
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| author | Yu ZH Ma WQ Ren JW Zhang XT Chu L |
| author_facet | Yu ZH Ma WQ Ren JW Zhang XT Chu L |
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| description | Zhi-Hong Yu,1,* Wei-Qin Ma,2,* Ji-Wei Ren,3 Xu-Ting Zhang,3 Lin Chu3 1Department of Ultrasound, Shanxi Provincial People’s Hospital, The Fifth Hospital of Shanxi Medical University, The Fifth Clinical Medical College of Shanxi Medical University, Taiyuan, Shanxi, 030012, People’s Republic of China; 2Department of CT/MRI, Lvliang People’s Hospital, Shanxi Province, Lvliang, Shanxi, 033000, People’s Republic of China; 3Department of Radiology, Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan, Shanxi, 030013, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xu-Ting Zhang; Ji-Wei Ren, Department of Radiology, Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University, No. 3 Zhigongxin Street, Taiyuan, Shanxi, 030013, People’s Republic of China, Tel +86 18335172028, Email xuting_zhang@126.com; renjw2023@sxmu.edu.cnObjective: To examine the association between computed tomography (CT) imaging characteristics and programmed death ligand-1 (PD-L1) expression in patients with gastric adenocarcinoma (GAC), and to develop a nomogram model for prediction.Methods: The patients were randomly allocated into a training set and a validation set at a ratio of 7:3. The training set was further divided into a PD-L1 positive group and a PD-L1 negative group, based on the combined positive score (CPS). Univariate and multivariate logistic regression analyses were performed to identify independent predictors of PD-L1 positivity. A nomogram was developed to assess the model’s predictive performance, which was evaluated using the receiver operating characteristic (ROC) curve, calibration curve, and decision curve analysis (DCA). It was also compared with the model established by previous study.Results: Patients with PD-L1-positive gastric adenocarcinoma exhibited a higher prevalence of larger short diameters of lymph nodes (LNs) (≥ 1 cm), and lower CT attenuation values in the venous and delayed phases compared to those in the PD-L1-negative group. Short diameter of LNs, and CT attenuation values in the delayed phase were identified as independent predictors of PD-L1 positivity. The nomogram analysis indicated that CT attenuation values in the delayed phase were the most significant predictor of PD-L1 positivity, followed by short diameter of LNs.Conclusion: The GAC prediction model based on the CT imaging features is effective in predicting PD-L1 expression levels and demonstrates strong clinical applicability.Keywords: combined positive score, computed tomography, gastric adenocarcinoma, nomogram, programmed death ligand-1 |
| format | Article |
| id | doaj-art-98f6f6f971294527a8412e2ac8726f26 |
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| spelling | doaj-art-98f6f6f971294527a8412e2ac8726f262025-02-06T16:40:24ZengDove Medical PressJournal of Multidisciplinary Healthcare1178-23902025-02-01Volume 1860962199967Role of Computed Tomography in Predicting Programmed Death Ligand-1 Positivity in Gastric AdenocarcinomaYu ZHMa WQRen JWZhang XTChu LZhi-Hong Yu,1,* Wei-Qin Ma,2,* Ji-Wei Ren,3 Xu-Ting Zhang,3 Lin Chu3 1Department of Ultrasound, Shanxi Provincial People’s Hospital, The Fifth Hospital of Shanxi Medical University, The Fifth Clinical Medical College of Shanxi Medical University, Taiyuan, Shanxi, 030012, People’s Republic of China; 2Department of CT/MRI, Lvliang People’s Hospital, Shanxi Province, Lvliang, Shanxi, 033000, People’s Republic of China; 3Department of Radiology, Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan, Shanxi, 030013, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xu-Ting Zhang; Ji-Wei Ren, Department of Radiology, Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University, No. 3 Zhigongxin Street, Taiyuan, Shanxi, 030013, People’s Republic of China, Tel +86 18335172028, Email xuting_zhang@126.com; renjw2023@sxmu.edu.cnObjective: To examine the association between computed tomography (CT) imaging characteristics and programmed death ligand-1 (PD-L1) expression in patients with gastric adenocarcinoma (GAC), and to develop a nomogram model for prediction.Methods: The patients were randomly allocated into a training set and a validation set at a ratio of 7:3. The training set was further divided into a PD-L1 positive group and a PD-L1 negative group, based on the combined positive score (CPS). Univariate and multivariate logistic regression analyses were performed to identify independent predictors of PD-L1 positivity. A nomogram was developed to assess the model’s predictive performance, which was evaluated using the receiver operating characteristic (ROC) curve, calibration curve, and decision curve analysis (DCA). It was also compared with the model established by previous study.Results: Patients with PD-L1-positive gastric adenocarcinoma exhibited a higher prevalence of larger short diameters of lymph nodes (LNs) (≥ 1 cm), and lower CT attenuation values in the venous and delayed phases compared to those in the PD-L1-negative group. Short diameter of LNs, and CT attenuation values in the delayed phase were identified as independent predictors of PD-L1 positivity. The nomogram analysis indicated that CT attenuation values in the delayed phase were the most significant predictor of PD-L1 positivity, followed by short diameter of LNs.Conclusion: The GAC prediction model based on the CT imaging features is effective in predicting PD-L1 expression levels and demonstrates strong clinical applicability.Keywords: combined positive score, computed tomography, gastric adenocarcinoma, nomogram, programmed death ligand-1https://www.dovepress.com/role-of-computed-tomography-in-predicting-programmed-death-ligand-1-po-peer-reviewed-fulltext-article-JMDHcombined positive scorecomputed tomographygastric adenocarcinomanomogramprogrammed death ligand-1 |
| spellingShingle | Yu ZH Ma WQ Ren JW Zhang XT Chu L Role of Computed Tomography in Predicting Programmed Death Ligand-1 Positivity in Gastric Adenocarcinoma Journal of Multidisciplinary Healthcare combined positive score computed tomography gastric adenocarcinoma nomogram programmed death ligand-1 |
| title | Role of Computed Tomography in Predicting Programmed Death Ligand-1 Positivity in Gastric Adenocarcinoma |
| title_full | Role of Computed Tomography in Predicting Programmed Death Ligand-1 Positivity in Gastric Adenocarcinoma |
| title_fullStr | Role of Computed Tomography in Predicting Programmed Death Ligand-1 Positivity in Gastric Adenocarcinoma |
| title_full_unstemmed | Role of Computed Tomography in Predicting Programmed Death Ligand-1 Positivity in Gastric Adenocarcinoma |
| title_short | Role of Computed Tomography in Predicting Programmed Death Ligand-1 Positivity in Gastric Adenocarcinoma |
| title_sort | role of computed tomography in predicting programmed death ligand 1 positivity in gastric adenocarcinoma |
| topic | combined positive score computed tomography gastric adenocarcinoma nomogram programmed death ligand-1 |
| url | https://www.dovepress.com/role-of-computed-tomography-in-predicting-programmed-death-ligand-1-po-peer-reviewed-fulltext-article-JMDH |
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