Correlation between neutrophils-to-lymphocyte ratio and soluble FMS-like tyrosine kinase 1 in pregnant women with preeclampsia
Preeclampsia (PE) is a multi-system syndrome in pregnancy that affects 5-10% of pregnancies and is a significant cause of perinatal morbidity and mortality. Therefore, an early and precise diagnosis of PE is needed. Several biomarkers have been used for this diagnosis. The neutrophil-to-lymphocyte...
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PAGEPress Publications
2025-04-01
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| author | Kiki Rizki Amelia Efendi Lukas Nurbani Bangsawan Isharyah Sunarno Retno Budiarti Farid Sriwijaya Qadar |
| author_facet | Kiki Rizki Amelia Efendi Lukas Nurbani Bangsawan Isharyah Sunarno Retno Budiarti Farid Sriwijaya Qadar |
| author_sort | Kiki Rizki Amelia |
| collection | DOAJ |
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Preeclampsia (PE) is a multi-system syndrome in pregnancy that affects 5-10% of pregnancies and is a significant cause of perinatal morbidity and mortality. Therefore, an early and precise diagnosis of PE is needed. Several biomarkers have been used for this diagnosis. The neutrophil-to-lymphocyte ratio (NLR) is a potential biomarker that can be assessed through routine blood tests, but few studies have been conducted to compare NLR with other conventional markers. This study analyzes the correlation between NLR and soluble FMS-like tyrosine kinase 1 (sFLT-1) levels in pregnant women with PE. This study used a cross-sectional study among 88 patients divided into two groups (normal n=44, PE n=44) by consecutive sampling. All research subjects took venous blood samples and performed routine blood tests and sFLT-1. All statistical analyses were performed using the Statistical Program for Social Sciences (IBM SPSS 24, Chicago, IL, USA). There was no significant difference between the NLR in the control and PE groups, which were 5.45 (0.5) and 5.87 (5.5), respectively. The sFLT-1 marker increased significantly and increased in normal pregnancy and PE, namely 6336 (579) pg/mL and 18,775 (9841) pg/mL. NLR and log sFLT-1 were not correlated in PE (rho=0.11, p=0.451), but they were related in normal pregnancy (rho=0.705, p<0.001). In conclusion, there is a difference in sFLT-1 levels in PE and controls but no difference in the NLR biomarker. NLR does not correlate with the sFLT-1 biomarker.
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| format | Article |
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| publishDate | 2025-04-01 |
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| spelling | doaj-art-98f5f494632648a1aa9542dfa1a810dd2025-08-20T03:06:43ZengPAGEPress PublicationsItalian Journal of Medicine1877-93441877-93522025-04-0110.4081/itjm.2025.1924Correlation between neutrophils-to-lymphocyte ratio and soluble FMS-like tyrosine kinase 1 in pregnant women with preeclampsiaKiki Rizki Amelia0Efendi Lukas1Nurbani Bangsawan2Isharyah Sunarno3Retno Budiarti Farid4Sriwijaya Qadar5Department of Obstetrics and Gynecology, Faculty of Medicine, Hasanuddin University, MakassarDepartment of Obstetrics and Gynecology, Faculty of Medicine, Hasanuddin University, MakassarDepartment of Obstetrics and Gynecology, Faculty of Medicine, Hasanuddin University, MakassarDepartment of Obstetrics and Gynecology, Faculty of Medicine, Hasanuddin University, MakassarDepartment of Obstetrics and Gynecology, Faculty of Medicine, Hasanuddin University, MakassarDepartment of Obstetrics and Gynecology, Faculty of Medicine, Hasanuddin University, Makassar Preeclampsia (PE) is a multi-system syndrome in pregnancy that affects 5-10% of pregnancies and is a significant cause of perinatal morbidity and mortality. Therefore, an early and precise diagnosis of PE is needed. Several biomarkers have been used for this diagnosis. The neutrophil-to-lymphocyte ratio (NLR) is a potential biomarker that can be assessed through routine blood tests, but few studies have been conducted to compare NLR with other conventional markers. This study analyzes the correlation between NLR and soluble FMS-like tyrosine kinase 1 (sFLT-1) levels in pregnant women with PE. This study used a cross-sectional study among 88 patients divided into two groups (normal n=44, PE n=44) by consecutive sampling. All research subjects took venous blood samples and performed routine blood tests and sFLT-1. All statistical analyses were performed using the Statistical Program for Social Sciences (IBM SPSS 24, Chicago, IL, USA). There was no significant difference between the NLR in the control and PE groups, which were 5.45 (0.5) and 5.87 (5.5), respectively. The sFLT-1 marker increased significantly and increased in normal pregnancy and PE, namely 6336 (579) pg/mL and 18,775 (9841) pg/mL. NLR and log sFLT-1 were not correlated in PE (rho=0.11, p=0.451), but they were related in normal pregnancy (rho=0.705, p<0.001). In conclusion, there is a difference in sFLT-1 levels in PE and controls but no difference in the NLR biomarker. NLR does not correlate with the sFLT-1 biomarker. https://www.italjmed.org/ijm/article/view/1924Neutrophils-to-lymphocyte ratiosoluble FMS-like tyrosine 1preeclampsia |
| spellingShingle | Kiki Rizki Amelia Efendi Lukas Nurbani Bangsawan Isharyah Sunarno Retno Budiarti Farid Sriwijaya Qadar Correlation between neutrophils-to-lymphocyte ratio and soluble FMS-like tyrosine kinase 1 in pregnant women with preeclampsia Italian Journal of Medicine Neutrophils-to-lymphocyte ratio soluble FMS-like tyrosine 1 preeclampsia |
| title | Correlation between neutrophils-to-lymphocyte ratio and soluble FMS-like tyrosine kinase 1 in pregnant women with preeclampsia |
| title_full | Correlation between neutrophils-to-lymphocyte ratio and soluble FMS-like tyrosine kinase 1 in pregnant women with preeclampsia |
| title_fullStr | Correlation between neutrophils-to-lymphocyte ratio and soluble FMS-like tyrosine kinase 1 in pregnant women with preeclampsia |
| title_full_unstemmed | Correlation between neutrophils-to-lymphocyte ratio and soluble FMS-like tyrosine kinase 1 in pregnant women with preeclampsia |
| title_short | Correlation between neutrophils-to-lymphocyte ratio and soluble FMS-like tyrosine kinase 1 in pregnant women with preeclampsia |
| title_sort | correlation between neutrophils to lymphocyte ratio and soluble fms like tyrosine kinase 1 in pregnant women with preeclampsia |
| topic | Neutrophils-to-lymphocyte ratio soluble FMS-like tyrosine 1 preeclampsia |
| url | https://www.italjmed.org/ijm/article/view/1924 |
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