NUCKS1 promotes invasion and metastasis of colorectal cancer by stabilizing HDAC2 and activating AKT

Abstract Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 (NUCKS1) functions as an oncogene in colorectal cancer (CRC), promotes the progression of CRC, and is associated with poor prognosis in patients. Studies have found that NUCKS1 promotes tumor cell metastasis, yet its role in...

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Bibliographic Details
Main Authors: Liaoliao Zhu, Ting Zhao, Haichuan Su, Junqiang Li, Xiangjing Shen, Liang Zhang, Jun Chen, Yang Song
Format: Article
Language:English
Published: Nature Publishing Group 2025-06-01
Series:Oncogenesis
Online Access:https://doi.org/10.1038/s41389-025-00562-5
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