Cardiomyocyte Triglyceride Accumulation and Reduced Ventricular Function in Mice with Obesity Reflect Increased Long Chain Fatty Acid Uptake and De Novo Fatty Acid Synthesis

Cardiomyocyte Triglyceride Accumulation and Reduced Ventricular Function in Mice with Obesity Reflect Increased Long Chain Fatty Acid Uptake and De Novo Fatty Acid Synthesis

A nonarteriosclerotic cardiomyopathy is increasingly seen in obese patients. Seeking a rodent model, we studied cardiac histology, function, cardiomyocyte fatty acid uptake, and transporter gene expression in male C57BL/6J control mice and three obesity groups: similar mice fed a high-fat diet (HFD)...

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Main Authors: Fengxia Ge, Chunguang Hu, Eiichi Hyodo, Kotaro Arai, Shengli Zhou, Harrison Lobdell IV, José L. Walewski, Shunichi Homma, Paul D. Berk
Format: Article
Language:English
Published: Wiley 2012-01-01
Series:Journal of Obesity
Online Access:http://dx.doi.org/10.1155/2012/205648
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