Epigenetic Regulation in Mesenchymal Stem Cell Aging and Differentiation and Osteoporosis
Mesenchymal stem cells (MSCs) are a reliable source for cell-based regenerative medicine owing to their multipotency and biological functions. However, aging-induced systemic homeostasis disorders in vivo and cell culture passaging in vitro induce a functional decline of MSCs, switching MSCs to a se...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2020/8836258 |
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| _version_ | 1832566493713268736 |
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| author | Ruoxi Wang Yu Wang Lisha Zhu Yan Liu Weiran Li |
| author_facet | Ruoxi Wang Yu Wang Lisha Zhu Yan Liu Weiran Li |
| author_sort | Ruoxi Wang |
| collection | DOAJ |
| description | Mesenchymal stem cells (MSCs) are a reliable source for cell-based regenerative medicine owing to their multipotency and biological functions. However, aging-induced systemic homeostasis disorders in vivo and cell culture passaging in vitro induce a functional decline of MSCs, switching MSCs to a senescent status with impaired self-renewal capacity and biased differentiation tendency. MSC functional decline accounts for the pathogenesis of many diseases and, more importantly, limits the large-scale applications of MSCs in regenerative medicine. Growing evidence implies that epigenetic mechanisms are a critical regulator of the differentiation programs for cell fate and are subject to changes during aging. Thus, we here review epigenetic dysregulations that contribute to MSC aging and osteoporosis. Comprehending detailed epigenetic mechanisms could provide us with a novel horizon for dissecting MSC-related pathogenesis and further optimizing MSC-mediated regenerative therapies. |
| format | Article |
| id | doaj-art-98e367431f404c729b0a7d843ec16380 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-98e367431f404c729b0a7d843ec163802025-02-03T01:03:59ZengWileyStem Cells International1687-966X1687-96782020-01-01202010.1155/2020/88362588836258Epigenetic Regulation in Mesenchymal Stem Cell Aging and Differentiation and OsteoporosisRuoxi Wang0Yu Wang1Lisha Zhu2Yan Liu3Weiran Li4Laboratory of Biomimetic Nanomaterials, Department of Orthodontics, Peking University School and Hospital of Stomatology, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, Beijing 100081, ChinaLaboratory of Biomimetic Nanomaterials, Department of Orthodontics, Peking University School and Hospital of Stomatology, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, Beijing 100081, ChinaLaboratory of Biomimetic Nanomaterials, Department of Orthodontics, Peking University School and Hospital of Stomatology, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, Beijing 100081, ChinaLaboratory of Biomimetic Nanomaterials, Department of Orthodontics, Peking University School and Hospital of Stomatology, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, Beijing 100081, ChinaLaboratory of Biomimetic Nanomaterials, Department of Orthodontics, Peking University School and Hospital of Stomatology, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, Beijing 100081, ChinaMesenchymal stem cells (MSCs) are a reliable source for cell-based regenerative medicine owing to their multipotency and biological functions. However, aging-induced systemic homeostasis disorders in vivo and cell culture passaging in vitro induce a functional decline of MSCs, switching MSCs to a senescent status with impaired self-renewal capacity and biased differentiation tendency. MSC functional decline accounts for the pathogenesis of many diseases and, more importantly, limits the large-scale applications of MSCs in regenerative medicine. Growing evidence implies that epigenetic mechanisms are a critical regulator of the differentiation programs for cell fate and are subject to changes during aging. Thus, we here review epigenetic dysregulations that contribute to MSC aging and osteoporosis. Comprehending detailed epigenetic mechanisms could provide us with a novel horizon for dissecting MSC-related pathogenesis and further optimizing MSC-mediated regenerative therapies.http://dx.doi.org/10.1155/2020/8836258 |
| spellingShingle | Ruoxi Wang Yu Wang Lisha Zhu Yan Liu Weiran Li Epigenetic Regulation in Mesenchymal Stem Cell Aging and Differentiation and Osteoporosis Stem Cells International |
| title | Epigenetic Regulation in Mesenchymal Stem Cell Aging and Differentiation and Osteoporosis |
| title_full | Epigenetic Regulation in Mesenchymal Stem Cell Aging and Differentiation and Osteoporosis |
| title_fullStr | Epigenetic Regulation in Mesenchymal Stem Cell Aging and Differentiation and Osteoporosis |
| title_full_unstemmed | Epigenetic Regulation in Mesenchymal Stem Cell Aging and Differentiation and Osteoporosis |
| title_short | Epigenetic Regulation in Mesenchymal Stem Cell Aging and Differentiation and Osteoporosis |
| title_sort | epigenetic regulation in mesenchymal stem cell aging and differentiation and osteoporosis |
| url | http://dx.doi.org/10.1155/2020/8836258 |
| work_keys_str_mv | AT ruoxiwang epigeneticregulationinmesenchymalstemcellaginganddifferentiationandosteoporosis AT yuwang epigeneticregulationinmesenchymalstemcellaginganddifferentiationandosteoporosis AT lishazhu epigeneticregulationinmesenchymalstemcellaginganddifferentiationandosteoporosis AT yanliu epigeneticregulationinmesenchymalstemcellaginganddifferentiationandosteoporosis AT weiranli epigeneticregulationinmesenchymalstemcellaginganddifferentiationandosteoporosis |