A computational HLA allele-typing protocol to de-noise and leverage nanopore amplicon data

A computational HLA allele-typing protocol to de-noise and leverage nanopore amplicon data

Abstract Background Rapid turnaround time for a third-field resolution deceased donor human leukocyte antigen (HLA) typing is critical to improve organ transplantation outcomes. Third generation DNA sequencing platforms such as Oxford Nanopore (ONT) offer the opportunity to deliver rapid results at...

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Bibliographic Details
Main Authors: Jalal Siddiqui, Rohita Sinha, James Grantham, Ronnie LaCombe, Judith R. Alonzo, Scott Cowden, Steven Kleiboeker
Format: Article
Language:English
Published: BMC 2025-04-01
Series:BMC Genomics
Subjects:
Human leukocyte antigen typing
Organ transplantation
Oxford nanopore technology
Long read sequencing
Online Access:https://doi.org/10.1186/s12864-025-11547-4
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