Reprogramming of GM-CSF-dependent alveolar macrophages through GSK3 activity modulation

Reprogramming of GM-CSF-dependent alveolar macrophages through GSK3 activity modulation

Monocyte-derived macrophages recruited into inflamed tissues can acquire an array of functional states depending on the extracellular environment. Since the anti-inflammatory/pro-fibrotic macrophage profile is determined by MAFB, whose activity/protein levels are regulated by GSK3, we addressed the...

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Main Authors: Israel Ríos, Cristina Herrero, Mónica Torres-Torresano, Baltasar López-Navarro, María Teresa Schiaffino, Francisco Díaz Crespo, Alicia Nieto-Valle, Rafael Samaniego, Yolanda Sierra-Palomares, Eduardo Oliver, Fernando Revuelta-Salgado, Ricardo García-Luján, Paloma Sánchez-Mateos, Rafael Delgado, Amaya Puig-Kröger, Angel L Corbí
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-05-01
Series:eLife
Subjects:
GSK3
macrophages
macrophage reprogramming
Online Access:https://elifesciences.org/articles/102659
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