Exploring the Physiological Link between Psoriasis and Mood Disorders
Psoriasis is a chronic, immune-mediated skin condition with a high rate of psychiatric comorbidity, which often goes unrecognized. Beyond the negative consequences of mood disorders like depression and anxiety on patient quality of life, evidence suggests that these conditions can worsen the severit...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Dermatology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2015/409637 |
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| _version_ | 1849402909221978112 |
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| author | Cody J. Connor Vincent Liu Jess G. Fiedorowicz |
| author_facet | Cody J. Connor Vincent Liu Jess G. Fiedorowicz |
| author_sort | Cody J. Connor |
| collection | DOAJ |
| description | Psoriasis is a chronic, immune-mediated skin condition with a high rate of psychiatric comorbidity, which often goes unrecognized. Beyond the negative consequences of mood disorders like depression and anxiety on patient quality of life, evidence suggests that these conditions can worsen the severity of psoriatic disease. The mechanisms behind this relationship are not entirely understood, but inflammation seems to be a key feature linking psoriasis with mood disorders, and physiologic modulators of this inflammation, including the hypothalamic-pituitary-adrenal axis and sympathetic nervous system, demonstrate changes with psychopathology that may be contributory. Cyclical disruptions in the secretion of the sleep hormone, melatonin, are also observed in both depression and psoriasis, and with well-recognized anti-inflammatory and antioxidant activity, this aberration may represent a shared contributor to both conditions as well as common comorbidities like diabetes and cardiovascular disease. While understanding the complexities of the biological mechanisms at play will be key in optimizing the management of patients with comorbid psoriasis and depression/anxiety, one thing is certain: recognition of psychiatric comorbidity is an imperative first step in effectively treating these patients as a whole. Evidence that improvement in mood decreases psoriasis severity underscores how psychological awareness can be critical to clinicians in their practice. |
| format | Article |
| id | doaj-art-98dc4bf9f042423ebd234ab9131aebe7 |
| institution | Kabale University |
| issn | 1687-6105 1687-6113 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Dermatology Research and Practice |
| spelling | doaj-art-98dc4bf9f042423ebd234ab9131aebe72025-08-20T03:37:23ZengWileyDermatology Research and Practice1687-61051687-61132015-01-01201510.1155/2015/409637409637Exploring the Physiological Link between Psoriasis and Mood DisordersCody J. Connor0Vincent Liu1Jess G. Fiedorowicz2Department of Family Medicine, Broadlawns Medical Center, Des Moines, IA 50314, USADepartment of Dermatology, University of Iowa, Iowa City, IA 52242, USADepartment of Psychiatry, University of Iowa, Iowa City, IA 52242, USAPsoriasis is a chronic, immune-mediated skin condition with a high rate of psychiatric comorbidity, which often goes unrecognized. Beyond the negative consequences of mood disorders like depression and anxiety on patient quality of life, evidence suggests that these conditions can worsen the severity of psoriatic disease. The mechanisms behind this relationship are not entirely understood, but inflammation seems to be a key feature linking psoriasis with mood disorders, and physiologic modulators of this inflammation, including the hypothalamic-pituitary-adrenal axis and sympathetic nervous system, demonstrate changes with psychopathology that may be contributory. Cyclical disruptions in the secretion of the sleep hormone, melatonin, are also observed in both depression and psoriasis, and with well-recognized anti-inflammatory and antioxidant activity, this aberration may represent a shared contributor to both conditions as well as common comorbidities like diabetes and cardiovascular disease. While understanding the complexities of the biological mechanisms at play will be key in optimizing the management of patients with comorbid psoriasis and depression/anxiety, one thing is certain: recognition of psychiatric comorbidity is an imperative first step in effectively treating these patients as a whole. Evidence that improvement in mood decreases psoriasis severity underscores how psychological awareness can be critical to clinicians in their practice.http://dx.doi.org/10.1155/2015/409637 |
| spellingShingle | Cody J. Connor Vincent Liu Jess G. Fiedorowicz Exploring the Physiological Link between Psoriasis and Mood Disorders Dermatology Research and Practice |
| title | Exploring the Physiological Link between Psoriasis and Mood Disorders |
| title_full | Exploring the Physiological Link between Psoriasis and Mood Disorders |
| title_fullStr | Exploring the Physiological Link between Psoriasis and Mood Disorders |
| title_full_unstemmed | Exploring the Physiological Link between Psoriasis and Mood Disorders |
| title_short | Exploring the Physiological Link between Psoriasis and Mood Disorders |
| title_sort | exploring the physiological link between psoriasis and mood disorders |
| url | http://dx.doi.org/10.1155/2015/409637 |
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