High platelet-to-albumin ratio is associated with 30-day mortality in critically ill patients
Abstract Background The role of inflammation and hypoproteinemia in influencing outcomes of critically ill patients has been widely recognized. However, there is a paucity of research on the prognostic value of the platelet-to-albumin ratio (PAR) in critically ill patients. Therefore, the aim of thi...
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| Language: | English |
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BMC
2024-12-01
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| Series: | European Journal of Medical Research |
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| Online Access: | https://doi.org/10.1186/s40001-024-02235-2 |
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| author | Chun-Lin Liu Qing-Nian Wu Zhi-Ying Deng Ping Chen Shi-Qiang Guo |
| author_facet | Chun-Lin Liu Qing-Nian Wu Zhi-Ying Deng Ping Chen Shi-Qiang Guo |
| author_sort | Chun-Lin Liu |
| collection | DOAJ |
| description | Abstract Background The role of inflammation and hypoproteinemia in influencing outcomes of critically ill patients has been widely recognized. However, there is a paucity of research on the prognostic value of the platelet-to-albumin ratio (PAR) in critically ill patients. Therefore, the aim of this study is to assess the prognostic significance of PAR in this population. Methods Patients diagnosed with critical illnesses from January 2020 to October 2022 were retrospectively enrolled in our study. Baseline demographic and clinical data were collected for each participant. Platelet counts and albumin levels were measured at baseline, and the PAR was calculated. The area under the receiver operating characteristic curve, Kaplan–Meier survival analysis, and multivariate Cox regression analysis were used to predict 30-day mortality. Results Three hundred and seventy-eight patients diagnosed with critical illness were categorized into two groups: survivors (n = 299) and non-survivors (n = 79). Analysis of the 30-day outcome revealed that the area under the curve (AUC) for the PAR (AUC: 0.705; 95% CI 0.639–0.771; p < 0.001) was significantly higher than that for albumin (AUC: 0.673; 95% CI 0.609–0.736; p < 0.001), but slightly lower than that for the APACHE II score (AUC: 0.713; 95% CI 0.650–0.777; p < 0.001). In addition, the Kaplan–Meier survival analysis demonstrated a significantly higher 30-day mortality in the high-PAR group. Furthermore, Cox regression analysis identified albumin (HR: 0.936; 95% CI 0.895–0.978; p = 0.003), APACHE II score (HR: 1.225; 95% CI 1.149–1.305; p < 0.001), and high PAR (HR: 1.237; 95% CI 1.130–1.353; p < 0.001) as independent risk factors for the prognosis of critically ill patients. Conclusions The PAR has emerged as a significant prognostic indicator in critically ill patients, with an elevated ratio being associated with poorer clinical outcomes. |
| format | Article |
| id | doaj-art-98d7f995057d4629b378f409b7486b5c |
| institution | Kabale University |
| issn | 2047-783X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
| record_format | Article |
| series | European Journal of Medical Research |
| spelling | doaj-art-98d7f995057d4629b378f409b7486b5c2024-12-29T12:14:22ZengBMCEuropean Journal of Medical Research2047-783X2024-12-012911710.1186/s40001-024-02235-2High platelet-to-albumin ratio is associated with 30-day mortality in critically ill patientsChun-Lin Liu0Qing-Nian Wu1Zhi-Ying Deng2Ping Chen3Shi-Qiang Guo4Department of Laboratory Medicine, The Sixth Affiliated Hospital, School of Medicine, South China University of TechnologyDepartment of Laboratory Medicine, The Sixth Affiliated Hospital, School of Medicine, South China University of TechnologyDepartment of Laboratory Medicine, The Sixth Affiliated Hospital, School of Medicine, South China University of TechnologyDepartment of Laboratory Medicine, The Sixth Affiliated Hospital, School of Medicine, South China University of TechnologyDepartment of Clinical Research Laboratory, The Sixth Affiliated Hospital, School of Medicine, South China University of TechnologyAbstract Background The role of inflammation and hypoproteinemia in influencing outcomes of critically ill patients has been widely recognized. However, there is a paucity of research on the prognostic value of the platelet-to-albumin ratio (PAR) in critically ill patients. Therefore, the aim of this study is to assess the prognostic significance of PAR in this population. Methods Patients diagnosed with critical illnesses from January 2020 to October 2022 were retrospectively enrolled in our study. Baseline demographic and clinical data were collected for each participant. Platelet counts and albumin levels were measured at baseline, and the PAR was calculated. The area under the receiver operating characteristic curve, Kaplan–Meier survival analysis, and multivariate Cox regression analysis were used to predict 30-day mortality. Results Three hundred and seventy-eight patients diagnosed with critical illness were categorized into two groups: survivors (n = 299) and non-survivors (n = 79). Analysis of the 30-day outcome revealed that the area under the curve (AUC) for the PAR (AUC: 0.705; 95% CI 0.639–0.771; p < 0.001) was significantly higher than that for albumin (AUC: 0.673; 95% CI 0.609–0.736; p < 0.001), but slightly lower than that for the APACHE II score (AUC: 0.713; 95% CI 0.650–0.777; p < 0.001). In addition, the Kaplan–Meier survival analysis demonstrated a significantly higher 30-day mortality in the high-PAR group. Furthermore, Cox regression analysis identified albumin (HR: 0.936; 95% CI 0.895–0.978; p = 0.003), APACHE II score (HR: 1.225; 95% CI 1.149–1.305; p < 0.001), and high PAR (HR: 1.237; 95% CI 1.130–1.353; p < 0.001) as independent risk factors for the prognosis of critically ill patients. Conclusions The PAR has emerged as a significant prognostic indicator in critically ill patients, with an elevated ratio being associated with poorer clinical outcomes.https://doi.org/10.1186/s40001-024-02235-2Platelet countAlbuminCritical illnessMortality |
| spellingShingle | Chun-Lin Liu Qing-Nian Wu Zhi-Ying Deng Ping Chen Shi-Qiang Guo High platelet-to-albumin ratio is associated with 30-day mortality in critically ill patients European Journal of Medical Research Platelet count Albumin Critical illness Mortality |
| title | High platelet-to-albumin ratio is associated with 30-day mortality in critically ill patients |
| title_full | High platelet-to-albumin ratio is associated with 30-day mortality in critically ill patients |
| title_fullStr | High platelet-to-albumin ratio is associated with 30-day mortality in critically ill patients |
| title_full_unstemmed | High platelet-to-albumin ratio is associated with 30-day mortality in critically ill patients |
| title_short | High platelet-to-albumin ratio is associated with 30-day mortality in critically ill patients |
| title_sort | high platelet to albumin ratio is associated with 30 day mortality in critically ill patients |
| topic | Platelet count Albumin Critical illness Mortality |
| url | https://doi.org/10.1186/s40001-024-02235-2 |
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