Impact of molecular genetic profle of meningiomas on the clinical course and recurrence using combined modality treatment
Introduction. Meningioma is one of the most common central nervous system tumors, accounting for 39.7 % of all primary brain tumors. The tumor originates from arachnoid meningothelial cells and is characterized by a wide range of histological types classified into 15 subtypes. The histological class...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Russian Academy of Sciences, Tomsk National Research Medical Center
2024-01-01
|
| Series: | Сибирский онкологический журнал |
| Subjects: | |
| Online Access: | https://www.siboncoj.ru/jour/article/view/2844 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850041194370826240 |
|---|---|
| author | G. S. Sergeev A. S. Gaytan M. A. Travin A. B. Ponomarev M. A. Afonina I. A. Savitskaya F. Yakhya A. L. Krivoshapkin |
| author_facet | G. S. Sergeev A. S. Gaytan M. A. Travin A. B. Ponomarev M. A. Afonina I. A. Savitskaya F. Yakhya A. L. Krivoshapkin |
| author_sort | G. S. Sergeev |
| collection | DOAJ |
| description | Introduction. Meningioma is one of the most common central nervous system tumors, accounting for 39.7 % of all primary brain tumors. The tumor originates from arachnoid meningothelial cells and is characterized by a wide range of histological types classified into 15 subtypes. The histological classification of meningiomas allows us to predict meningioma behavior and the risk of disease recurrence, as well as to define treatment strategies. However, clinical outcomes in histological subgroups of patients are often inconsistent with the histological grade of malignancy. Thus, a more reliable method is needed both to determine the histological subtype of the tumor and to predict the clinical course of the disease with the potential for targeted treatment.The purpose of the study was to summarize the available data on the effect of results of the genomic and proteomic tumor analysis on carcinogenesis with the relationship between the mutational changes and noninvasive diagnosis, treatment and the course of the disease.Material and Methods. Literature search was carried out in the PubMed, Elibrary system, publications were included mainly from 2010 to 2023. with the identification of articles by the keyword “genetic analysis of meningiomas” and synonyms. 550 articles were found, of which 55 were used to write a literature review.Conclusion. The study of the molecular genetic profile of meningiomas will improve the classification and establish a correlation with MRI data, the course of the disease and prognosis. |
| format | Article |
| id | doaj-art-98d4fcb9cdb64b82beadba266ad5cde4 |
| institution | DOAJ |
| issn | 1814-4861 2312-3168 |
| language | Russian |
| publishDate | 2024-01-01 |
| publisher | Russian Academy of Sciences, Tomsk National Research Medical Center |
| record_format | Article |
| series | Сибирский онкологический журнал |
| spelling | doaj-art-98d4fcb9cdb64b82beadba266ad5cde42025-08-20T02:55:49ZrusRussian Academy of Sciences, Tomsk National Research Medical CenterСибирский онкологический журнал1814-48612312-31682024-01-0122613815210.21294/1814-4861-2023-22-6-138-1521192Impact of molecular genetic profle of meningiomas on the clinical course and recurrence using combined modality treatmentG. S. Sergeev0A. S. Gaytan1M. A. Travin2A. B. Ponomarev3M. A. Afonina4I. A. Savitskaya5F. Yakhya6A. L. Krivoshapkin7Neurosurgery Clinic, European Medical CenterNeurosurgery Clinic, European Medical Center; RUDN UniversityNeurosurgery Clinic, European Medical CenterI.M. Sechenov First Moscow State Medical University of the Ministry of Health of the RussiaI.M. Sechenov First Moscow State Medical University of the Ministry of Health of the RussiaNeurosurgery Clinic, European Medical CenterRUDN UniversityNeurosurgery Clinic, European Medical Center; RUDN University; E.N. Meshalkin National Medical Research Center of the Ministry of Health of RussiaIntroduction. Meningioma is one of the most common central nervous system tumors, accounting for 39.7 % of all primary brain tumors. The tumor originates from arachnoid meningothelial cells and is characterized by a wide range of histological types classified into 15 subtypes. The histological classification of meningiomas allows us to predict meningioma behavior and the risk of disease recurrence, as well as to define treatment strategies. However, clinical outcomes in histological subgroups of patients are often inconsistent with the histological grade of malignancy. Thus, a more reliable method is needed both to determine the histological subtype of the tumor and to predict the clinical course of the disease with the potential for targeted treatment.The purpose of the study was to summarize the available data on the effect of results of the genomic and proteomic tumor analysis on carcinogenesis with the relationship between the mutational changes and noninvasive diagnosis, treatment and the course of the disease.Material and Methods. Literature search was carried out in the PubMed, Elibrary system, publications were included mainly from 2010 to 2023. with the identification of articles by the keyword “genetic analysis of meningiomas” and synonyms. 550 articles were found, of which 55 were used to write a literature review.Conclusion. The study of the molecular genetic profile of meningiomas will improve the classification and establish a correlation with MRI data, the course of the disease and prognosis.https://www.siboncoj.ru/jour/article/view/2844meningiomagenomic and proteomic analysismesenchymal tumors of the cnstargeted treatment |
| spellingShingle | G. S. Sergeev A. S. Gaytan M. A. Travin A. B. Ponomarev M. A. Afonina I. A. Savitskaya F. Yakhya A. L. Krivoshapkin Impact of molecular genetic profle of meningiomas on the clinical course and recurrence using combined modality treatment Сибирский онкологический журнал meningioma genomic and proteomic analysis mesenchymal tumors of the cns targeted treatment |
| title | Impact of molecular genetic profle of meningiomas on the clinical course and recurrence using combined modality treatment |
| title_full | Impact of molecular genetic profle of meningiomas on the clinical course and recurrence using combined modality treatment |
| title_fullStr | Impact of molecular genetic profle of meningiomas on the clinical course and recurrence using combined modality treatment |
| title_full_unstemmed | Impact of molecular genetic profle of meningiomas on the clinical course and recurrence using combined modality treatment |
| title_short | Impact of molecular genetic profle of meningiomas on the clinical course and recurrence using combined modality treatment |
| title_sort | impact of molecular genetic profle of meningiomas on the clinical course and recurrence using combined modality treatment |
| topic | meningioma genomic and proteomic analysis mesenchymal tumors of the cns targeted treatment |
| url | https://www.siboncoj.ru/jour/article/view/2844 |
| work_keys_str_mv | AT gssergeev impactofmoleculargeneticprofleofmeningiomasontheclinicalcourseandrecurrenceusingcombinedmodalitytreatment AT asgaytan impactofmoleculargeneticprofleofmeningiomasontheclinicalcourseandrecurrenceusingcombinedmodalitytreatment AT matravin impactofmoleculargeneticprofleofmeningiomasontheclinicalcourseandrecurrenceusingcombinedmodalitytreatment AT abponomarev impactofmoleculargeneticprofleofmeningiomasontheclinicalcourseandrecurrenceusingcombinedmodalitytreatment AT maafonina impactofmoleculargeneticprofleofmeningiomasontheclinicalcourseandrecurrenceusingcombinedmodalitytreatment AT iasavitskaya impactofmoleculargeneticprofleofmeningiomasontheclinicalcourseandrecurrenceusingcombinedmodalitytreatment AT fyakhya impactofmoleculargeneticprofleofmeningiomasontheclinicalcourseandrecurrenceusingcombinedmodalitytreatment AT alkrivoshapkin impactofmoleculargeneticprofleofmeningiomasontheclinicalcourseandrecurrenceusingcombinedmodalitytreatment |