The role of long non-coding RNAs in cardiovascular diseases: A comprehensive review
Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality worldwide, posing significant challenges to healthcare systems. Despite advances in medical interventions, the molecular mechanisms underlying CVDs are not yet fully understood. For decades, protein-coding genes have bee...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2025-04-01
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| Series: | Non-coding RNA Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2468054024001732 |
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| author | Xuena Xie Meiwen Huang Shudong Ma Qiqi Xin Yuying Wang Lantian Hu Han Zhao Pengqi Li Mei Liu Rong Yuan Yu Miao Yizhun Zhu Weihong Cong |
| author_facet | Xuena Xie Meiwen Huang Shudong Ma Qiqi Xin Yuying Wang Lantian Hu Han Zhao Pengqi Li Mei Liu Rong Yuan Yu Miao Yizhun Zhu Weihong Cong |
| author_sort | Xuena Xie |
| collection | DOAJ |
| description | Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality worldwide, posing significant challenges to healthcare systems. Despite advances in medical interventions, the molecular mechanisms underlying CVDs are not yet fully understood. For decades, protein-coding genes have been the focus of CVD research. However, recent advances in genomics have highlighted the importance of long non-coding RNAs (lncRNAs) in cardiovascular health and disease. Changes in lncRNA expression specific to tissues may result from various internal or external factors, leading to tissue damage, organ dysfunction, and disease. In this review, we provide a comprehensive discussion of the regulatory mechanisms underlying lncRNAs and their roles in the pathogenesis and progression of CVDs, such as coronary heart disease, atherosclerosis, heart failure, arrhythmias, cardiomyopathies, and diabetic cardiomyopathy, to explore their potential as therapeutic targets and diagnostic biomarkers. |
| format | Article |
| id | doaj-art-98d497fc787d4879b63fb24f5d9d4acf |
| institution | OA Journals |
| issn | 2468-0540 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Non-coding RNA Research |
| spelling | doaj-art-98d497fc787d4879b63fb24f5d9d4acf2025-08-20T02:13:40ZengKeAi Communications Co., Ltd.Non-coding RNA Research2468-05402025-04-011115818710.1016/j.ncrna.2024.12.009The role of long non-coding RNAs in cardiovascular diseases: A comprehensive reviewXuena Xie0Meiwen Huang1Shudong Ma2Qiqi Xin3Yuying Wang4Lantian Hu5Han Zhao6Pengqi Li7Mei Liu8Rong Yuan9Yu Miao10Yizhun Zhu11Weihong Cong12School of Pharmacy, Faculty of Medicine, Macau University of Science and Technology, Macau SAR, 999078, China; Laboratory of Cardiovascular Diseases, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, ChinaSchool of Pharmacy, Faculty of Medicine, Macau University of Science and Technology, Macau SAR, 999078, China; Laboratory of Cardiovascular Diseases, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, ChinaLaboratory of Cardiovascular Diseases, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China; Faculty of Chinese Medicine, Macau University of Science and Technology, 999078, ChinaLaboratory of Cardiovascular Diseases, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, ChinaLaboratory of Cardiovascular Diseases, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, ChinaLaboratory of Cardiovascular Diseases, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China; Tianjin University of Traditional Chinese Medicine, Tianjin 301617, ChinaLaboratory of Cardiovascular Diseases, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China; Tianjin University of Traditional Chinese Medicine, Tianjin 301617, ChinaLaboratory of Cardiovascular Diseases, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, ChinaLaboratory of Cardiovascular Diseases, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China; Tianjin University of Traditional Chinese Medicine, Tianjin 301617, ChinaLaboratory of Cardiovascular Diseases, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, ChinaLaboratory of Cardiovascular Diseases, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, ChinaSchool of Pharmacy, Faculty of Medicine, Macau University of Science and Technology, Macau SAR, 999078, China; Corresponding author.School of Pharmacy, Faculty of Medicine, Macau University of Science and Technology, Macau SAR, 999078, China; Laboratory of Cardiovascular Diseases, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China; Corresponding author. School of Pharmacy, Faculty of Medicine, Macau University of Science and Technology, Macau SAR, 999078, ChinaCardiovascular diseases (CVDs) are the leading cause of morbidity and mortality worldwide, posing significant challenges to healthcare systems. Despite advances in medical interventions, the molecular mechanisms underlying CVDs are not yet fully understood. For decades, protein-coding genes have been the focus of CVD research. However, recent advances in genomics have highlighted the importance of long non-coding RNAs (lncRNAs) in cardiovascular health and disease. Changes in lncRNA expression specific to tissues may result from various internal or external factors, leading to tissue damage, organ dysfunction, and disease. In this review, we provide a comprehensive discussion of the regulatory mechanisms underlying lncRNAs and their roles in the pathogenesis and progression of CVDs, such as coronary heart disease, atherosclerosis, heart failure, arrhythmias, cardiomyopathies, and diabetic cardiomyopathy, to explore their potential as therapeutic targets and diagnostic biomarkers.http://www.sciencedirect.com/science/article/pii/S2468054024001732Long non-coding RNACardiovascular diseaseBiomarkersDiagnosisTherapy |
| spellingShingle | Xuena Xie Meiwen Huang Shudong Ma Qiqi Xin Yuying Wang Lantian Hu Han Zhao Pengqi Li Mei Liu Rong Yuan Yu Miao Yizhun Zhu Weihong Cong The role of long non-coding RNAs in cardiovascular diseases: A comprehensive review Non-coding RNA Research Long non-coding RNA Cardiovascular disease Biomarkers Diagnosis Therapy |
| title | The role of long non-coding RNAs in cardiovascular diseases: A comprehensive review |
| title_full | The role of long non-coding RNAs in cardiovascular diseases: A comprehensive review |
| title_fullStr | The role of long non-coding RNAs in cardiovascular diseases: A comprehensive review |
| title_full_unstemmed | The role of long non-coding RNAs in cardiovascular diseases: A comprehensive review |
| title_short | The role of long non-coding RNAs in cardiovascular diseases: A comprehensive review |
| title_sort | role of long non coding rnas in cardiovascular diseases a comprehensive review |
| topic | Long non-coding RNA Cardiovascular disease Biomarkers Diagnosis Therapy |
| url | http://www.sciencedirect.com/science/article/pii/S2468054024001732 |
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