Cortical macro- and microstructural changes in isolated rapid eye movement sleep behavior disorder
Abstract Cortical mean diffusivity (cMD), a marker of cortical microstructural changes in neurodegenerative disorders, remains unexplored in isolated REM sleep behavior disorder (iRBD), a prodromal stage of Lewy body (LB) diseases. Its relationship with cortical thickness (CTh), clinical features, a...
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Nature Portfolio
2025-07-01
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| Series: | npj Parkinson's Disease |
| Online Access: | https://doi.org/10.1038/s41531-025-01058-0 |
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| author | Jèssica Pardo Ignacio Roura Victor Montal Cristina Martín-Barceló Javier Oltra Anna Campabadal Núria Bargalló Mònica Serradell Gerard Mayà Angelica Montini Carles Gaig Claustre Pont-Sunyer Juan Fortea Alex Iranzo Carme Junqué Bàrbara Segura |
| author_facet | Jèssica Pardo Ignacio Roura Victor Montal Cristina Martín-Barceló Javier Oltra Anna Campabadal Núria Bargalló Mònica Serradell Gerard Mayà Angelica Montini Carles Gaig Claustre Pont-Sunyer Juan Fortea Alex Iranzo Carme Junqué Bàrbara Segura |
| author_sort | Jèssica Pardo |
| collection | DOAJ |
| description | Abstract Cortical mean diffusivity (cMD), a marker of cortical microstructural changes in neurodegenerative disorders, remains unexplored in isolated REM sleep behavior disorder (iRBD), a prodromal stage of Lewy body (LB) diseases. Its relationship with cortical thickness (CTh), clinical features, and neuropsychological performance is also unknown. We assessed cMD and CTh in thirty-six patients with iRBD at high risk of conversion and 29 healthy controls (HC), examining associations with clinical and cognitive measures. Effect sizes were calculated using Cohen’s d. Patients with iRBD showed increased cMD in rostral and caudal cortical regions compared to HC (d > 0.5). Cortical thinning was restricted to caudal areas. Higher cMD correlated with longer iRBD duration, later onset, MDS-UPDRS III, apathy, and poorer performance on Grooved Pegboard and Symbol-Digit Modality Tests. These findings suggest that cMD may be more sensitive than CTh and serve as a valuable imaging biomarker for detecting early cortical changes in prodromal LB diseases. |
| format | Article |
| id | doaj-art-98d20a8922e042ea840a2be1577cdc6c |
| institution | Kabale University |
| issn | 2373-8057 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Parkinson's Disease |
| spelling | doaj-art-98d20a8922e042ea840a2be1577cdc6c2025-08-20T03:37:23ZengNature Portfolionpj Parkinson's Disease2373-80572025-07-0111111010.1038/s41531-025-01058-0Cortical macro- and microstructural changes in isolated rapid eye movement sleep behavior disorderJèssica Pardo0Ignacio Roura1Victor Montal2Cristina Martín-Barceló3Javier Oltra4Anna Campabadal5Núria Bargalló6Mònica Serradell7Gerard Mayà8Angelica Montini9Carles Gaig10Claustre Pont-Sunyer11Juan Fortea12Alex Iranzo13Carme Junqué14Bàrbara Segura15Medical Psychology Unit, Department of Medicine, Institute of Neurosciences, University of BarcelonaMedical Psychology Unit, Department of Medicine, Institute of Neurosciences, University of BarcelonaSant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau, Universitat Autònoma de BarcelonaMedical Psychology Unit, Department of Medicine, Institute of Neurosciences, University of BarcelonaMedical Psychology Unit, Department of Medicine, Institute of Neurosciences, University of BarcelonaMedical Psychology Unit, Department of Medicine, Institute of Neurosciences, University of BarcelonaFundació de Recerca Clínic Barcelona-Institut d’Investigacions Biomèdiques August Pi i Sunyer (FRCB-IDIBAPS)Sleep Disorders Center, Neurology Service, Hospital Clínic Universitari de Barcelona, University of BarcelonaSleep Disorders Center, Neurology Service, Hospital Clínic Universitari de Barcelona, University of BarcelonaSleep Disorders Center, Neurology Service, Hospital Clínic Universitari de Barcelona, University of BarcelonaFundació de Recerca Clínic Barcelona-Institut d’Investigacions Biomèdiques August Pi i Sunyer (FRCB-IDIBAPS)Servei de Neurologia Unitat de Trastorns del Moviment, Fundació Privada Hospital Asil de GranollersSant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau, Universitat Autònoma de BarcelonaFundació de Recerca Clínic Barcelona-Institut d’Investigacions Biomèdiques August Pi i Sunyer (FRCB-IDIBAPS)Medical Psychology Unit, Department of Medicine, Institute of Neurosciences, University of BarcelonaMedical Psychology Unit, Department of Medicine, Institute of Neurosciences, University of BarcelonaAbstract Cortical mean diffusivity (cMD), a marker of cortical microstructural changes in neurodegenerative disorders, remains unexplored in isolated REM sleep behavior disorder (iRBD), a prodromal stage of Lewy body (LB) diseases. Its relationship with cortical thickness (CTh), clinical features, and neuropsychological performance is also unknown. We assessed cMD and CTh in thirty-six patients with iRBD at high risk of conversion and 29 healthy controls (HC), examining associations with clinical and cognitive measures. Effect sizes were calculated using Cohen’s d. Patients with iRBD showed increased cMD in rostral and caudal cortical regions compared to HC (d > 0.5). Cortical thinning was restricted to caudal areas. Higher cMD correlated with longer iRBD duration, later onset, MDS-UPDRS III, apathy, and poorer performance on Grooved Pegboard and Symbol-Digit Modality Tests. These findings suggest that cMD may be more sensitive than CTh and serve as a valuable imaging biomarker for detecting early cortical changes in prodromal LB diseases.https://doi.org/10.1038/s41531-025-01058-0 |
| spellingShingle | Jèssica Pardo Ignacio Roura Victor Montal Cristina Martín-Barceló Javier Oltra Anna Campabadal Núria Bargalló Mònica Serradell Gerard Mayà Angelica Montini Carles Gaig Claustre Pont-Sunyer Juan Fortea Alex Iranzo Carme Junqué Bàrbara Segura Cortical macro- and microstructural changes in isolated rapid eye movement sleep behavior disorder npj Parkinson's Disease |
| title | Cortical macro- and microstructural changes in isolated rapid eye movement sleep behavior disorder |
| title_full | Cortical macro- and microstructural changes in isolated rapid eye movement sleep behavior disorder |
| title_fullStr | Cortical macro- and microstructural changes in isolated rapid eye movement sleep behavior disorder |
| title_full_unstemmed | Cortical macro- and microstructural changes in isolated rapid eye movement sleep behavior disorder |
| title_short | Cortical macro- and microstructural changes in isolated rapid eye movement sleep behavior disorder |
| title_sort | cortical macro and microstructural changes in isolated rapid eye movement sleep behavior disorder |
| url | https://doi.org/10.1038/s41531-025-01058-0 |
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