Heme regulates protein interactions and phosphorylation of BACH2 intrinsically disordered region in humoral response

Heme regulates protein interactions and phosphorylation of BACH2 intrinsically disordered region in humoral response

Summary: Heme is known to bind to the intrinsically disordered region (IDR) to regulate protein function. The binding of heme to the IDR of transcription factor BACH2 promotes plasma cell differentiation, but the molecular basis is unknown. Heme was found to increase BACH2 IDR interaction with TANK-...

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Main Authors: Miki Watanabe-Matsui, Shun Kadoya, Kei Segawa, Hiroki Shima, Tadashi Nakagawa, Yuko Nagasawa, Shuichiro Hayashi, Mitsuyo Matsumoto, Mariko Ikeda, Akihiko Muto, Kyoko Ochiai, Long C. Nguyen, Katsumi Doh-Ura, Mikako Shirouzu, Keiko Nakayama, Kazutaka Murayama, Kazuhiko Igarashi
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:iScience
Subjects:
Biochemistry
Structural biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004224027561
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