Blood-based transcriptomic biomarkers for response to [177Lu]Lu-DOTA-TATE therapy in neuroendocrine tumors

Blood-based transcriptomic biomarkers for response to [177Lu]Lu-DOTA-TATE therapy in neuroendocrine tumors

Abstract Background [177Lu]Lu-DOTA-TATE is an effective treatment for metastatic neuroendocrine tumors (NETs) expressing somatostatin receptors. While the tumor uptake [177Lu]Lu-DOTA-TATE of has shown potential as a predictive biomarker, patient response to the treatment varies significantly. In thi...

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Bibliographic Details
Main Authors: Hyunpil Sung, Sungwoo Bae, Minseok Suh, Hongyoon Choi, Hyung-Jun Im, Gi Jeong Cheon, Keon Wook Kang
Format: Article
Language:English
Published: SpringerOpen 2025-08-01
Series:EJNMMI Research
Subjects:
Neuroendocrine tumor
RNA sequencing
Blood biomarker
[177Lu]Lu-DOTA-TATE
Online Access:https://doi.org/10.1186/s13550-025-01284-w
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