Extracellular vesicle microRNA cargoes: candidates for diagnosis and targeted therapy of cutaneous wound healing
Background Non-healing wounds lead to tissue dysfunction, contributing to pathological conditions and compromising overall health. Recently, microRNAs have been shown to regulate diverse biological events, including cell migration, proliferation, angiogenesis, scar formation, and wound closure. Inte...
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| Format: | Article |
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Taylor & Francis Group
2025-12-01
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| Series: | Annals of Medicine |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/07853890.2025.2534851 |
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| author | Mai Thi Le Huy Hoang Dao Xuan-Hung Nguyen Tinh Van Nguyen Tu Dac Nguyen Uyen Thi Trang Than |
| author_facet | Mai Thi Le Huy Hoang Dao Xuan-Hung Nguyen Tinh Van Nguyen Tu Dac Nguyen Uyen Thi Trang Than |
| author_sort | Mai Thi Le |
| collection | DOAJ |
| description | Background Non-healing wounds lead to tissue dysfunction, contributing to pathological conditions and compromising overall health. Recently, microRNAs have been shown to regulate diverse biological events, including cell migration, proliferation, angiogenesis, scar formation, and wound closure. Interestingly, cells selectively sort microRNAs into extracellular vesicles, which can be up-taken by cells to regulate the healing process. Consequently, extracellular vesicles and their microRNA content serve as an in-situ reservoir, providing tissue-specific signals on demand.Aims and methods This review aims to explore the association between microRNAs and the wound healing process, and the roles of extracellular vesicle-derived miRNAs in different cell populations within the wound microenvironment. We searched PubMed, Web of Science, and Scopus using the keywords: exosomes, mesenchymal stem cell-derived exosomes, wound healing, and microRNA. Relevant data were collected and summarized.Results This review provided information about extracellular vesicles, microRNA biogenesis, and their roles in wound healing. Results highlighted the roles of extracellular vesicle-derived microRNAs in anti-inflammatory responses, promoting cell migration, proliferation, and differentiation while inhibiting apoptosis during wound repair. Beyond their natural functions, extracellular vesicles and their microRNA cargoes hold significant potential for therapeutic and diagnostic applications in wound healing. We also outlined the potential use of extracellular vesicle-derived microRNAs as drug delivery systems and miRNA-based monitoring tools.Conclusion Extracellular vesicle-derived microRNAs play important roles in wound healing. Despite their promise, challenges such as lack of standardization in isolation, precise delivery, and reliable quantification methods remain obstacles for clinical implementation in disease diagnosis and prognosis. |
| format | Article |
| id | doaj-art-98c1b398eefd46539d6cf606b0e445d3 |
| institution | Kabale University |
| issn | 0785-3890 1365-2060 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Annals of Medicine |
| spelling | doaj-art-98c1b398eefd46539d6cf606b0e445d32025-08-20T03:55:49ZengTaylor & Francis GroupAnnals of Medicine0785-38901365-20602025-12-0157110.1080/07853890.2025.2534851Extracellular vesicle microRNA cargoes: candidates for diagnosis and targeted therapy of cutaneous wound healingMai Thi Le0Huy Hoang Dao1Xuan-Hung Nguyen2Tinh Van Nguyen3Tu Dac Nguyen4Uyen Thi Trang Than5Vinmec Hi-Tech Center, Vinmec Healthcare System, Hanoi, VietnamVinmec Hi-Tech Center, Vinmec Healthcare System, Hanoi, VietnamVinmec Hi-Tech Center, Vinmec Healthcare System, Hanoi, VietnamVinmec Hi-Tech Center, Vinmec Healthcare System, Hanoi, VietnamVinmec Hi-Tech Center, Vinmec Healthcare System, Hanoi, VietnamVinmec Hi-Tech Center, Vinmec Healthcare System, Hanoi, VietnamBackground Non-healing wounds lead to tissue dysfunction, contributing to pathological conditions and compromising overall health. Recently, microRNAs have been shown to regulate diverse biological events, including cell migration, proliferation, angiogenesis, scar formation, and wound closure. Interestingly, cells selectively sort microRNAs into extracellular vesicles, which can be up-taken by cells to regulate the healing process. Consequently, extracellular vesicles and their microRNA content serve as an in-situ reservoir, providing tissue-specific signals on demand.Aims and methods This review aims to explore the association between microRNAs and the wound healing process, and the roles of extracellular vesicle-derived miRNAs in different cell populations within the wound microenvironment. We searched PubMed, Web of Science, and Scopus using the keywords: exosomes, mesenchymal stem cell-derived exosomes, wound healing, and microRNA. Relevant data were collected and summarized.Results This review provided information about extracellular vesicles, microRNA biogenesis, and their roles in wound healing. Results highlighted the roles of extracellular vesicle-derived microRNAs in anti-inflammatory responses, promoting cell migration, proliferation, and differentiation while inhibiting apoptosis during wound repair. Beyond their natural functions, extracellular vesicles and their microRNA cargoes hold significant potential for therapeutic and diagnostic applications in wound healing. We also outlined the potential use of extracellular vesicle-derived microRNAs as drug delivery systems and miRNA-based monitoring tools.Conclusion Extracellular vesicle-derived microRNAs play important roles in wound healing. Despite their promise, challenges such as lack of standardization in isolation, precise delivery, and reliable quantification methods remain obstacles for clinical implementation in disease diagnosis and prognosis.https://www.tandfonline.com/doi/10.1080/07853890.2025.2534851Extracellular vesiclesmicroRNAstherapeutic applicationsdiagnostic applicationscutaneous wound healing |
| spellingShingle | Mai Thi Le Huy Hoang Dao Xuan-Hung Nguyen Tinh Van Nguyen Tu Dac Nguyen Uyen Thi Trang Than Extracellular vesicle microRNA cargoes: candidates for diagnosis and targeted therapy of cutaneous wound healing Annals of Medicine Extracellular vesicles microRNAs therapeutic applications diagnostic applications cutaneous wound healing |
| title | Extracellular vesicle microRNA cargoes: candidates for diagnosis and targeted therapy of cutaneous wound healing |
| title_full | Extracellular vesicle microRNA cargoes: candidates for diagnosis and targeted therapy of cutaneous wound healing |
| title_fullStr | Extracellular vesicle microRNA cargoes: candidates for diagnosis and targeted therapy of cutaneous wound healing |
| title_full_unstemmed | Extracellular vesicle microRNA cargoes: candidates for diagnosis and targeted therapy of cutaneous wound healing |
| title_short | Extracellular vesicle microRNA cargoes: candidates for diagnosis and targeted therapy of cutaneous wound healing |
| title_sort | extracellular vesicle microrna cargoes candidates for diagnosis and targeted therapy of cutaneous wound healing |
| topic | Extracellular vesicles microRNAs therapeutic applications diagnostic applications cutaneous wound healing |
| url | https://www.tandfonline.com/doi/10.1080/07853890.2025.2534851 |
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