Feedback driven autonomous cycles of assembly and disassembly from minimal building blocks
Abstract The construction of complex systems by simple chemicals that can display emergent network dynamics might contribute to our understanding of complex behavior from simple organic reactions. Here we design single amino acid/dipeptide-based systems that exhibit multiple periodic changes of (dis...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-024-54197-y |
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| author | Antara Reja Sangam Jha Ashley Sreejan Sumit Pal Subhajit Bal Chetan Gadgil Dibyendu Das |
| author_facet | Antara Reja Sangam Jha Ashley Sreejan Sumit Pal Subhajit Bal Chetan Gadgil Dibyendu Das |
| author_sort | Antara Reja |
| collection | DOAJ |
| description | Abstract The construction of complex systems by simple chemicals that can display emergent network dynamics might contribute to our understanding of complex behavior from simple organic reactions. Here we design single amino acid/dipeptide-based systems that exhibit multiple periodic changes of (dis)assembly under non-equilibrium conditions in closed system, importantly in the absence of evolved biocatalysts. The two-component based building block exploits pH driven non-covalent assembly and time-delayed accelerated catalysis from self-assembled state to install orthogonal feedback loops with a single batch of reactants. Mathematical modelling of the reaction network establishes that the oscillations are transient for this network structure and helps to predict the relative contribution of the feedback loop to the ability of the system to exhibit such transient oscillation. Such autonomous systems with purely synthetic molecules are the starting point that can enable the design of active materials with emergent properties. |
| format | Article |
| id | doaj-art-98b54300dbf04d84b4be341673c3bc67 |
| institution | Kabale University |
| issn | 2041-1723 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-98b54300dbf04d84b4be341673c3bc672024-11-24T12:32:22ZengNature PortfolioNature Communications2041-17232024-11-0115111010.1038/s41467-024-54197-yFeedback driven autonomous cycles of assembly and disassembly from minimal building blocksAntara Reja0Sangam Jha1Ashley Sreejan2Sumit Pal3Subhajit Bal4Chetan Gadgil5Dibyendu Das6Department of Chemical Sciences and Centre for Advanced Functional Materials, Indian Institute of Science Education and Research (IISER) KolkataDepartment of Chemical Sciences and Centre for Advanced Functional Materials, Indian Institute of Science Education and Research (IISER) KolkataChemical Engineering and Process Development, CSIR-National Chemical LaboratoryDepartment of Chemical Sciences and Centre for Advanced Functional Materials, Indian Institute of Science Education and Research (IISER) KolkataDepartment of Chemical Sciences and Centre for Advanced Functional Materials, Indian Institute of Science Education and Research (IISER) KolkataChemical Engineering and Process Development, CSIR-National Chemical LaboratoryDepartment of Chemical Sciences and Centre for Advanced Functional Materials, Indian Institute of Science Education and Research (IISER) KolkataAbstract The construction of complex systems by simple chemicals that can display emergent network dynamics might contribute to our understanding of complex behavior from simple organic reactions. Here we design single amino acid/dipeptide-based systems that exhibit multiple periodic changes of (dis)assembly under non-equilibrium conditions in closed system, importantly in the absence of evolved biocatalysts. The two-component based building block exploits pH driven non-covalent assembly and time-delayed accelerated catalysis from self-assembled state to install orthogonal feedback loops with a single batch of reactants. Mathematical modelling of the reaction network establishes that the oscillations are transient for this network structure and helps to predict the relative contribution of the feedback loop to the ability of the system to exhibit such transient oscillation. Such autonomous systems with purely synthetic molecules are the starting point that can enable the design of active materials with emergent properties.https://doi.org/10.1038/s41467-024-54197-y |
| spellingShingle | Antara Reja Sangam Jha Ashley Sreejan Sumit Pal Subhajit Bal Chetan Gadgil Dibyendu Das Feedback driven autonomous cycles of assembly and disassembly from minimal building blocks Nature Communications |
| title | Feedback driven autonomous cycles of assembly and disassembly from minimal building blocks |
| title_full | Feedback driven autonomous cycles of assembly and disassembly from minimal building blocks |
| title_fullStr | Feedback driven autonomous cycles of assembly and disassembly from minimal building blocks |
| title_full_unstemmed | Feedback driven autonomous cycles of assembly and disassembly from minimal building blocks |
| title_short | Feedback driven autonomous cycles of assembly and disassembly from minimal building blocks |
| title_sort | feedback driven autonomous cycles of assembly and disassembly from minimal building blocks |
| url | https://doi.org/10.1038/s41467-024-54197-y |
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