A novel mutation in ZP3 causes human ovulatory dysfunction and oocyte maturation arrest

A novel mutation in ZP3 causes human ovulatory dysfunction and oocyte maturation arrest

Abstract Background Ovulatory dysfunction and oocyte maturation arrest are among the common causes of female infertility, but the genetic etiology of these phenotypes is not well understood. The ZP3 gene is responsible for coding the oocyte zona pellucida (ZP), and ZP3 mutation clinically manifests...

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Bibliographic Details
Main Authors: Yingxue Liu, Guanghui Yuan, Yameng Hui, Xiaoxiao Wang, Jiashan Li, Jiao Zhuang, Huaiqian Dou, Linfang Han, Duan Li, Cuifang Hao
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Journal of Ovarian Research
Subjects:
Oocyte maturation arrest
Ovulatory dysfunction
ZP3 mutation
Whole-exome sequencing
Dual trigger
Online Access:https://doi.org/10.1186/s13048-025-01706-2
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