Right-ventricular mechanics assessed by cardiovascular magnetic resonance feature tracking in children with hypertrophic cardiomyopathy.
<h4>Background</h4>Although hypertrophic cardiomyopathy (HCM) is considered a disease of the left ventricle (LV), right ventricular (RV) abnormalities have also been reported on. Cardiovascular magnetic resonance feature tracking (CMR-FT) accurately and reproducibly quantifies RV myocard...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2021-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0248725&type=printable |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850181664026656768 |
|---|---|
| author | Joanna Petryka-Mazurkiewicz Lidia Ziolkowska Łukasz Mazurkiewicz Monika Kowalczyk-Domagała Agnieszka Boruc Mateusz Śpiewak Magdalena Marczak Grażyna Brzezinska-Rajszys |
| author_facet | Joanna Petryka-Mazurkiewicz Lidia Ziolkowska Łukasz Mazurkiewicz Monika Kowalczyk-Domagała Agnieszka Boruc Mateusz Śpiewak Magdalena Marczak Grażyna Brzezinska-Rajszys |
| author_sort | Joanna Petryka-Mazurkiewicz |
| collection | DOAJ |
| description | <h4>Background</h4>Although hypertrophic cardiomyopathy (HCM) is considered a disease of the left ventricle (LV), right ventricular (RV) abnormalities have also been reported on. Cardiovascular magnetic resonance feature tracking (CMR-FT) accurately and reproducibly quantifies RV myocardial deformation.<h4>Aim</h4>To investigate RV deformation disorders in childhood HCM using CMR-FT.<h4>Material and methods</h4>Consecutive subjects aged <18 years with echocardiographic evidence of HCM were enrolled. Cardiovascular magnetic resonance (CMR) was performed including RV volumetric and functional assessment, and late gadolinium enhancement (LGE) imaging.<h4>Results</h4>We included 54 children (37 males, 68.5%) with HCM, of which 28 patients (51.8%; mean extent of 2.18 ± 2.34% of LV mass) had late gadolinium enhancement. LV outflow tract obstruction (LVOTO) was detected in 19 subjects (35.2%). In patients with LVOTO, RV global longitudinal strain (RVGLS) (-16.1±5.0 vs. -20.7±5.3, p<0.01), RVGLS rate (-1.05±0.30 vs. -1.26±0.40, p = 0.03), RV radial strain (RVR) (15.8±7.7 vs. 22.1±7.0, p<0.01) and RVR rate (0.95±0.35 vs. 1.6±0.44, p<0.01) were lower than in patients without LVOTO. The RVR rate (p<0.01) was lower in patients with LGE in comparison to patients without LGE.<h4>Conclusions</h4>Children with HCM, especially with LVOTO, have significantly reduced indices of RV mechanics despite normal RV systolic function. It seems that the degree of LVOT obstruction is responsible for compromising the RV dynamics, rather than either mass or the amount of LV fibrosis. |
| format | Article |
| id | doaj-art-98b0c599eabb47e2862ed14d4dbe96df |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-98b0c599eabb47e2862ed14d4dbe96df2025-08-20T02:17:50ZengPublic Library of Science (PLoS)PLoS ONE1932-62032021-01-01163e024872510.1371/journal.pone.0248725Right-ventricular mechanics assessed by cardiovascular magnetic resonance feature tracking in children with hypertrophic cardiomyopathy.Joanna Petryka-MazurkiewiczLidia ZiolkowskaŁukasz MazurkiewiczMonika Kowalczyk-DomagałaAgnieszka BorucMateusz ŚpiewakMagdalena MarczakGrażyna Brzezinska-Rajszys<h4>Background</h4>Although hypertrophic cardiomyopathy (HCM) is considered a disease of the left ventricle (LV), right ventricular (RV) abnormalities have also been reported on. Cardiovascular magnetic resonance feature tracking (CMR-FT) accurately and reproducibly quantifies RV myocardial deformation.<h4>Aim</h4>To investigate RV deformation disorders in childhood HCM using CMR-FT.<h4>Material and methods</h4>Consecutive subjects aged <18 years with echocardiographic evidence of HCM were enrolled. Cardiovascular magnetic resonance (CMR) was performed including RV volumetric and functional assessment, and late gadolinium enhancement (LGE) imaging.<h4>Results</h4>We included 54 children (37 males, 68.5%) with HCM, of which 28 patients (51.8%; mean extent of 2.18 ± 2.34% of LV mass) had late gadolinium enhancement. LV outflow tract obstruction (LVOTO) was detected in 19 subjects (35.2%). In patients with LVOTO, RV global longitudinal strain (RVGLS) (-16.1±5.0 vs. -20.7±5.3, p<0.01), RVGLS rate (-1.05±0.30 vs. -1.26±0.40, p = 0.03), RV radial strain (RVR) (15.8±7.7 vs. 22.1±7.0, p<0.01) and RVR rate (0.95±0.35 vs. 1.6±0.44, p<0.01) were lower than in patients without LVOTO. The RVR rate (p<0.01) was lower in patients with LGE in comparison to patients without LGE.<h4>Conclusions</h4>Children with HCM, especially with LVOTO, have significantly reduced indices of RV mechanics despite normal RV systolic function. It seems that the degree of LVOT obstruction is responsible for compromising the RV dynamics, rather than either mass or the amount of LV fibrosis.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0248725&type=printable |
| spellingShingle | Joanna Petryka-Mazurkiewicz Lidia Ziolkowska Łukasz Mazurkiewicz Monika Kowalczyk-Domagała Agnieszka Boruc Mateusz Śpiewak Magdalena Marczak Grażyna Brzezinska-Rajszys Right-ventricular mechanics assessed by cardiovascular magnetic resonance feature tracking in children with hypertrophic cardiomyopathy. PLoS ONE |
| title | Right-ventricular mechanics assessed by cardiovascular magnetic resonance feature tracking in children with hypertrophic cardiomyopathy. |
| title_full | Right-ventricular mechanics assessed by cardiovascular magnetic resonance feature tracking in children with hypertrophic cardiomyopathy. |
| title_fullStr | Right-ventricular mechanics assessed by cardiovascular magnetic resonance feature tracking in children with hypertrophic cardiomyopathy. |
| title_full_unstemmed | Right-ventricular mechanics assessed by cardiovascular magnetic resonance feature tracking in children with hypertrophic cardiomyopathy. |
| title_short | Right-ventricular mechanics assessed by cardiovascular magnetic resonance feature tracking in children with hypertrophic cardiomyopathy. |
| title_sort | right ventricular mechanics assessed by cardiovascular magnetic resonance feature tracking in children with hypertrophic cardiomyopathy |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0248725&type=printable |
| work_keys_str_mv | AT joannapetrykamazurkiewicz rightventricularmechanicsassessedbycardiovascularmagneticresonancefeaturetrackinginchildrenwithhypertrophiccardiomyopathy AT lidiaziolkowska rightventricularmechanicsassessedbycardiovascularmagneticresonancefeaturetrackinginchildrenwithhypertrophiccardiomyopathy AT łukaszmazurkiewicz rightventricularmechanicsassessedbycardiovascularmagneticresonancefeaturetrackinginchildrenwithhypertrophiccardiomyopathy AT monikakowalczykdomagała rightventricularmechanicsassessedbycardiovascularmagneticresonancefeaturetrackinginchildrenwithhypertrophiccardiomyopathy AT agnieszkaboruc rightventricularmechanicsassessedbycardiovascularmagneticresonancefeaturetrackinginchildrenwithhypertrophiccardiomyopathy AT mateuszspiewak rightventricularmechanicsassessedbycardiovascularmagneticresonancefeaturetrackinginchildrenwithhypertrophiccardiomyopathy AT magdalenamarczak rightventricularmechanicsassessedbycardiovascularmagneticresonancefeaturetrackinginchildrenwithhypertrophiccardiomyopathy AT grazynabrzezinskarajszys rightventricularmechanicsassessedbycardiovascularmagneticresonancefeaturetrackinginchildrenwithhypertrophiccardiomyopathy |