Sarcopenia as a predictor of mortality in centenarians: insights from a prospective cohort study
Abstract Background & aims Centenarians represent a unique population where predictors of mortality are understudied.Studies have shown that sarcopenia is associated with adverse health outcomes and premature death in elderly patients. The aim of our study was to explore the association between...
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BMC
2025-07-01
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| Series: | BMC Geriatrics |
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| Online Access: | https://doi.org/10.1186/s12877-025-06167-2 |
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| author | Yun Tang Hongyan Lin Meijuan Chen Yuanyuan Zhong Xiaochu Wu Li Wang |
| author_facet | Yun Tang Hongyan Lin Meijuan Chen Yuanyuan Zhong Xiaochu Wu Li Wang |
| author_sort | Yun Tang |
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| description | Abstract Background & aims Centenarians represent a unique population where predictors of mortality are understudied.Studies have shown that sarcopenia is associated with adverse health outcomes and premature death in elderly patients. The aim of our study was to explore the association between sarcopenia and centenarian mortality. Methods Our study is a prospective cohort study. Muscle mass was measured using bioelectrical impedance analysis (BIA), and the relative skeletal muscle index (RSMI) was adjusted for height to reduce individual differences. Sarcopenia is defined according to the Asian Sarcopenia Working Group’s (AWGS)2019 updated diagnostic criteria for sarcopenia, it introduces the concept of “possible sarcopenia”, defined as the presence of only low muscular strength or low physical performance, specifically for primary health care or community health promotion to enable earlier lifestyle interventions. The survival time of centenarians with and without sarcopenia was compared using the Kaplan-Meier method, and the hazard ratio (HR) and 95% confidence interval (95% CI) for mortality were determined using the Cox proportional hazards regression model. Results A total of 98 centenarians were included in this study, with an average age of (102.2 ± 1.8) years. The prevalence of sarcopenia was 20.4%. The Cox proportional hazards model analysis showed that after adjusting for confounding factors, the risk of death was increased by 3.64 times in the sarcopenia group (HR = 4.64, 95% CI: 2.48–8.66). Conclusion Sarcopenia can serves as a significant predictor of long-term mortality in centenarians and functions as an important independent predictor. Trial registration The trial was registered at the Chinese Clinical Trial Center on 17-01-2019. Trial registration numbers 2018 − 463; ChiCTR1900020754. |
| format | Article |
| id | doaj-art-98aff199e8a54df78291aaaa4fed435a |
| institution | Kabale University |
| issn | 1471-2318 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
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| series | BMC Geriatrics |
| spelling | doaj-art-98aff199e8a54df78291aaaa4fed435a2025-08-20T03:45:32ZengBMCBMC Geriatrics1471-23182025-07-0125111110.1186/s12877-025-06167-2Sarcopenia as a predictor of mortality in centenarians: insights from a prospective cohort studyYun Tang0Hongyan Lin1Meijuan Chen2Yuanyuan Zhong3Xiaochu Wu4Li Wang5The People’s Hospital of LeshanThe People’s Hospital of LeshanThe People’s Hospital of LeshanThe People’s Hospital of LeshanNational Clinical Research Center for Geriatrics (WCHSCU), Sichuan University West China HospitalThe People’s Hospital of LeshanAbstract Background & aims Centenarians represent a unique population where predictors of mortality are understudied.Studies have shown that sarcopenia is associated with adverse health outcomes and premature death in elderly patients. The aim of our study was to explore the association between sarcopenia and centenarian mortality. Methods Our study is a prospective cohort study. Muscle mass was measured using bioelectrical impedance analysis (BIA), and the relative skeletal muscle index (RSMI) was adjusted for height to reduce individual differences. Sarcopenia is defined according to the Asian Sarcopenia Working Group’s (AWGS)2019 updated diagnostic criteria for sarcopenia, it introduces the concept of “possible sarcopenia”, defined as the presence of only low muscular strength or low physical performance, specifically for primary health care or community health promotion to enable earlier lifestyle interventions. The survival time of centenarians with and without sarcopenia was compared using the Kaplan-Meier method, and the hazard ratio (HR) and 95% confidence interval (95% CI) for mortality were determined using the Cox proportional hazards regression model. Results A total of 98 centenarians were included in this study, with an average age of (102.2 ± 1.8) years. The prevalence of sarcopenia was 20.4%. The Cox proportional hazards model analysis showed that after adjusting for confounding factors, the risk of death was increased by 3.64 times in the sarcopenia group (HR = 4.64, 95% CI: 2.48–8.66). Conclusion Sarcopenia can serves as a significant predictor of long-term mortality in centenarians and functions as an important independent predictor. Trial registration The trial was registered at the Chinese Clinical Trial Center on 17-01-2019. Trial registration numbers 2018 − 463; ChiCTR1900020754.https://doi.org/10.1186/s12877-025-06167-2CentenarianSarcopeniaLong-term deathPredictorRisk factorsHealthy aging |
| spellingShingle | Yun Tang Hongyan Lin Meijuan Chen Yuanyuan Zhong Xiaochu Wu Li Wang Sarcopenia as a predictor of mortality in centenarians: insights from a prospective cohort study BMC Geriatrics Centenarian Sarcopenia Long-term death Predictor Risk factors Healthy aging |
| title | Sarcopenia as a predictor of mortality in centenarians: insights from a prospective cohort study |
| title_full | Sarcopenia as a predictor of mortality in centenarians: insights from a prospective cohort study |
| title_fullStr | Sarcopenia as a predictor of mortality in centenarians: insights from a prospective cohort study |
| title_full_unstemmed | Sarcopenia as a predictor of mortality in centenarians: insights from a prospective cohort study |
| title_short | Sarcopenia as a predictor of mortality in centenarians: insights from a prospective cohort study |
| title_sort | sarcopenia as a predictor of mortality in centenarians insights from a prospective cohort study |
| topic | Centenarian Sarcopenia Long-term death Predictor Risk factors Healthy aging |
| url | https://doi.org/10.1186/s12877-025-06167-2 |
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