Synergistic effect of proteins and tannic acid-yielding systems with improved mechanical performance for use in load-bearing tissues
Developing bioactive hydrogels with mechanical properties resembling those of load-bearing connective tissues remains a significant challenge in the biomedical field. In this study, we address this limitation by incorporating human platelet lysate (PL) proteins, tannic acid (TA), and chitosan methac...
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| Format: | Article |
| Language: | English |
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IOP Publishing
2025-01-01
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| Series: | Materials Research Express |
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| Online Access: | https://doi.org/10.1088/2053-1591/adee7e |
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| author | Maria Clara Gomes Claudio Mortier Håvard J Haugen Jonny J Blaker João F Mano |
| author_facet | Maria Clara Gomes Claudio Mortier Håvard J Haugen Jonny J Blaker João F Mano |
| author_sort | Maria Clara Gomes |
| collection | DOAJ |
| description | Developing bioactive hydrogels with mechanical properties resembling those of load-bearing connective tissues remains a significant challenge in the biomedical field. In this study, we address this limitation by incorporating human platelet lysate (PL) proteins, tannic acid (TA), and chitosan methacrylate (CHI-MA) to formulate reinforced hydrogel systems with markedly improved mechanical performance. The resulting PL/CHI-MA/TA hydrogels exhibit exceptional mechanical characteristics, attaining strengths of approximately 7 MPa and stiffness values of 5 MPa, comparable to those found in load-bearing tissues such as cartilage. This improvement can be attributed to the synergistic effect, which enhances the interaction between PL proteins and the polymeric network, thereby increasing strength, toughness, and efficient energy dissipation. Moreover, these hydrogels support the adhesion and proliferation of human-derived adipose stem cells, underscoring their potential utility in tissue engineering and regenerative medicine applications targeting load-bearing connective tissues, such as cartilage. |
| format | Article |
| id | doaj-art-98ad817afdc246d69c4eaabd3b2576fe |
| institution | Kabale University |
| issn | 2053-1591 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | IOP Publishing |
| record_format | Article |
| series | Materials Research Express |
| spelling | doaj-art-98ad817afdc246d69c4eaabd3b2576fe2025-08-20T03:51:24ZengIOP PublishingMaterials Research Express2053-15912025-01-0112707540410.1088/2053-1591/adee7eSynergistic effect of proteins and tannic acid-yielding systems with improved mechanical performance for use in load-bearing tissuesMaria Clara Gomes0Claudio Mortier1Håvard J Haugen2https://orcid.org/0000-0002-6690-7233Jonny J Blaker3João F Mano4https://orcid.org/0000-0002-2342-3765Department of Chemistry, CICECO-Aveiro Institute of Materials, University of Aveiro , PortugalDepartment of Chemistry, CICECO-Aveiro Institute of Materials, University of Aveiro , Portugal; Institute of Clinical Dentistry, University of Oslo , NorwayInstitute of Clinical Dentistry, University of Oslo , NorwayInstitute of Clinical Dentistry, University of Oslo , Norway; Department of Materials & Henry Royce Institute, The University of Manchester , Manchester, United KingdomDepartment of Chemistry, CICECO-Aveiro Institute of Materials, University of Aveiro , PortugalDeveloping bioactive hydrogels with mechanical properties resembling those of load-bearing connective tissues remains a significant challenge in the biomedical field. In this study, we address this limitation by incorporating human platelet lysate (PL) proteins, tannic acid (TA), and chitosan methacrylate (CHI-MA) to formulate reinforced hydrogel systems with markedly improved mechanical performance. The resulting PL/CHI-MA/TA hydrogels exhibit exceptional mechanical characteristics, attaining strengths of approximately 7 MPa and stiffness values of 5 MPa, comparable to those found in load-bearing tissues such as cartilage. This improvement can be attributed to the synergistic effect, which enhances the interaction between PL proteins and the polymeric network, thereby increasing strength, toughness, and efficient energy dissipation. Moreover, these hydrogels support the adhesion and proliferation of human-derived adipose stem cells, underscoring their potential utility in tissue engineering and regenerative medicine applications targeting load-bearing connective tissues, such as cartilage.https://doi.org/10.1088/2053-1591/adee7eplatelet lysatesproteinsimproved mechanical propertieshydrogels |
| spellingShingle | Maria Clara Gomes Claudio Mortier Håvard J Haugen Jonny J Blaker João F Mano Synergistic effect of proteins and tannic acid-yielding systems with improved mechanical performance for use in load-bearing tissues Materials Research Express platelet lysates proteins improved mechanical properties hydrogels |
| title | Synergistic effect of proteins and tannic acid-yielding systems with improved mechanical performance for use in load-bearing tissues |
| title_full | Synergistic effect of proteins and tannic acid-yielding systems with improved mechanical performance for use in load-bearing tissues |
| title_fullStr | Synergistic effect of proteins and tannic acid-yielding systems with improved mechanical performance for use in load-bearing tissues |
| title_full_unstemmed | Synergistic effect of proteins and tannic acid-yielding systems with improved mechanical performance for use in load-bearing tissues |
| title_short | Synergistic effect of proteins and tannic acid-yielding systems with improved mechanical performance for use in load-bearing tissues |
| title_sort | synergistic effect of proteins and tannic acid yielding systems with improved mechanical performance for use in load bearing tissues |
| topic | platelet lysates proteins improved mechanical properties hydrogels |
| url | https://doi.org/10.1088/2053-1591/adee7e |
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