Paradigms and Controversies in the Treatment of HIV-Related Burkitt Lymphoma
Burkitt lymphoma (BL) is a very aggressive subtype of non-Hodgkin's lymphoma that occurs with higher frequency in patients with HIV/AIDS. Patients with HIV-related BL (HIV-BL) are usually treated with high-intensity, multi-agent chemotherapy regimens. The addition of the monoclonal antibody Ri...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Advances in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2012/403648 |
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| _version_ | 1849403099564736512 |
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| author | Adam M. Petrich Joseph A. Sparano Samir Parekh |
| author_facet | Adam M. Petrich Joseph A. Sparano Samir Parekh |
| author_sort | Adam M. Petrich |
| collection | DOAJ |
| description | Burkitt lymphoma (BL) is a very aggressive subtype of non-Hodgkin's lymphoma that occurs with higher frequency in patients with HIV/AIDS. Patients with HIV-related BL (HIV-BL) are usually treated with high-intensity, multi-agent chemotherapy regimens. The addition of the monoclonal antibody Rituximab to chemotherapy has also been studied in this setting. The potential risks and benefits of commonly used regimens are reviewed herein, along with a discussion of controversial issues in the practical management of HIV-BL, including concurrent anti-retroviral therapy, treatment of relapsed and/or refractory disease, and the role of stem cell transplantation. |
| format | Article |
| id | doaj-art-98abf01b4acb47b082b7f4cc199f4a57 |
| institution | Kabale University |
| issn | 1687-9104 1687-9112 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Hematology |
| spelling | doaj-art-98abf01b4acb47b082b7f4cc199f4a572025-08-20T03:37:22ZengWileyAdvances in Hematology1687-91041687-91122012-01-01201210.1155/2012/403648403648Paradigms and Controversies in the Treatment of HIV-Related Burkitt LymphomaAdam M. Petrich0Joseph A. Sparano1Samir Parekh2Division of Hematology/Oncology, Northwestern University, Chicago, IL 60611, USADepartment of Oncology, Montefiore Medical Center, Bronx, NY 10461, USADepartment of Oncology, Montefiore Medical Center, Bronx, NY 10461, USABurkitt lymphoma (BL) is a very aggressive subtype of non-Hodgkin's lymphoma that occurs with higher frequency in patients with HIV/AIDS. Patients with HIV-related BL (HIV-BL) are usually treated with high-intensity, multi-agent chemotherapy regimens. The addition of the monoclonal antibody Rituximab to chemotherapy has also been studied in this setting. The potential risks and benefits of commonly used regimens are reviewed herein, along with a discussion of controversial issues in the practical management of HIV-BL, including concurrent anti-retroviral therapy, treatment of relapsed and/or refractory disease, and the role of stem cell transplantation.http://dx.doi.org/10.1155/2012/403648 |
| spellingShingle | Adam M. Petrich Joseph A. Sparano Samir Parekh Paradigms and Controversies in the Treatment of HIV-Related Burkitt Lymphoma Advances in Hematology |
| title | Paradigms and Controversies in the Treatment of HIV-Related Burkitt Lymphoma |
| title_full | Paradigms and Controversies in the Treatment of HIV-Related Burkitt Lymphoma |
| title_fullStr | Paradigms and Controversies in the Treatment of HIV-Related Burkitt Lymphoma |
| title_full_unstemmed | Paradigms and Controversies in the Treatment of HIV-Related Burkitt Lymphoma |
| title_short | Paradigms and Controversies in the Treatment of HIV-Related Burkitt Lymphoma |
| title_sort | paradigms and controversies in the treatment of hiv related burkitt lymphoma |
| url | http://dx.doi.org/10.1155/2012/403648 |
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