The impact of genetic variants related to the fatty acid metabolic process pathway on milk production traits in Jersey cows
The synthesis of fatty acids plays a critical role in shaping milk production characteristics in dairy cattle. Thus, identifying effective haplotypes within the fatty acid metabolism pathway will provide novel and robust insights into the genetics of dairy cattle. This study aimed to comprehensively...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Animal Biotechnology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/10495398.2024.2396421 |
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| author | Sena Ardicli Nursen Senturk Berkay Bozkurt Huseyn Babayev Tuğçe Selvi Stephen Skolnick Hivdanur Ter Beyza Aktas Ayse Isık Ozgur Toprak Ay Ozge Ardicli Ozden Cobanoglu |
| author_facet | Sena Ardicli Nursen Senturk Berkay Bozkurt Huseyn Babayev Tuğçe Selvi Stephen Skolnick Hivdanur Ter Beyza Aktas Ayse Isık Ozgur Toprak Ay Ozge Ardicli Ozden Cobanoglu |
| author_sort | Sena Ardicli |
| collection | DOAJ |
| description | The synthesis of fatty acids plays a critical role in shaping milk production characteristics in dairy cattle. Thus, identifying effective haplotypes within the fatty acid metabolism pathway will provide novel and robust insights into the genetics of dairy cattle. This study aimed to comprehensively examine the individual and combined impacts of fundamental genes within the fatty acid metabolic process pathway in Jersey cows. A comprehensive phenotypic dataset was compiled, considering milk production traits, to summarize a cow’s productivity across three lactations. Genotyping was conducted through PCR-RFLP and Sanger sequencing, while the association between genotype and phenotype was quantified using linear mixed models. Moderate biodiversity and abundant variation suitable for haplotype analysis were observed across all examined markers. The individual effects of the FABP3, LTF and ANXA9 genes significantly influenced both milk yield and milk fat production. Additionally, this study reveals novel two-way interactions between genes in the fatty acid metabolism pathway that directly affect milk fat properties. Notably, we identified that the GGAAGG haplotype in FABP3×LTF×ANXA9 interaction may be a robust genetic marker concerning both milk fat yield and percentage. Consequently, the genotype combinations highlighted in this study serve as novel and efficient markers for assessing the fat content in cow’s milk. |
| format | Article |
| id | doaj-art-98aa9c9ea8d54ebfaf887ebde53e773e |
| institution | Kabale University |
| issn | 1049-5398 1532-2378 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Animal Biotechnology |
| spelling | doaj-art-98aa9c9ea8d54ebfaf887ebde53e773e2025-08-20T03:51:30ZengTaylor & Francis GroupAnimal Biotechnology1049-53981532-23782024-12-0135110.1080/10495398.2024.2396421The impact of genetic variants related to the fatty acid metabolic process pathway on milk production traits in Jersey cowsSena Ardicli0Nursen Senturk1Berkay Bozkurt2Huseyn Babayev3Tuğçe Selvi4Stephen Skolnick5Hivdanur Ter6Beyza Aktas7Ayse Isık8Ozgur Toprak Ay9Ozge Ardicli10Ozden Cobanoglu11Department of Genetics, Faculty of Veterinary Medicine, Bursa Uludag University, Bursa, TurkiyeDepartment of Genetics, Faculty of Veterinary Medicine, Bursa Uludag University, Bursa, TurkiyeDepartment of Biotechnology and Bioengineering, Graduate School of Science and Engineering, Izmir Institute of Technology, Izmir, TurkiyeSwiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, SwitzerlandDepartment of Animal Science, Faculty of Veterinary Medicine, Bursa Uludag University, Bursa, TurkiyeSwiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, SwitzerlandDepartment of Molecular Biology and Genetics, Faculty of Science and Arts, Bursa Uludag University, Bursa, TurkiyeDepartment of Molecular Biology and Genetics, Faculty of Science and Arts, Bursa Uludag University, Bursa, TurkiyeDepartment of Molecular Biology and Genetics, Faculty of Science and Arts, Bursa Uludag University, Bursa, TurkiyeDepartment of Molecular Biology and Genetics, Faculty of Science, Izmir Institute of Technology, İzmir, TurkiyeSwiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, SwitzerlandDepartment of Genetics, Faculty of Veterinary Medicine, Bursa Uludag University, Bursa, TurkiyeThe synthesis of fatty acids plays a critical role in shaping milk production characteristics in dairy cattle. Thus, identifying effective haplotypes within the fatty acid metabolism pathway will provide novel and robust insights into the genetics of dairy cattle. This study aimed to comprehensively examine the individual and combined impacts of fundamental genes within the fatty acid metabolic process pathway in Jersey cows. A comprehensive phenotypic dataset was compiled, considering milk production traits, to summarize a cow’s productivity across three lactations. Genotyping was conducted through PCR-RFLP and Sanger sequencing, while the association between genotype and phenotype was quantified using linear mixed models. Moderate biodiversity and abundant variation suitable for haplotype analysis were observed across all examined markers. The individual effects of the FABP3, LTF and ANXA9 genes significantly influenced both milk yield and milk fat production. Additionally, this study reveals novel two-way interactions between genes in the fatty acid metabolism pathway that directly affect milk fat properties. Notably, we identified that the GGAAGG haplotype in FABP3×LTF×ANXA9 interaction may be a robust genetic marker concerning both milk fat yield and percentage. Consequently, the genotype combinations highlighted in this study serve as novel and efficient markers for assessing the fat content in cow’s milk.https://www.tandfonline.com/doi/10.1080/10495398.2024.2396421Milk fat contentjersey breedgenetic markerfatty acid biosynthesis |
| spellingShingle | Sena Ardicli Nursen Senturk Berkay Bozkurt Huseyn Babayev Tuğçe Selvi Stephen Skolnick Hivdanur Ter Beyza Aktas Ayse Isık Ozgur Toprak Ay Ozge Ardicli Ozden Cobanoglu The impact of genetic variants related to the fatty acid metabolic process pathway on milk production traits in Jersey cows Animal Biotechnology Milk fat content jersey breed genetic marker fatty acid biosynthesis |
| title | The impact of genetic variants related to the fatty acid metabolic process pathway on milk production traits in Jersey cows |
| title_full | The impact of genetic variants related to the fatty acid metabolic process pathway on milk production traits in Jersey cows |
| title_fullStr | The impact of genetic variants related to the fatty acid metabolic process pathway on milk production traits in Jersey cows |
| title_full_unstemmed | The impact of genetic variants related to the fatty acid metabolic process pathway on milk production traits in Jersey cows |
| title_short | The impact of genetic variants related to the fatty acid metabolic process pathway on milk production traits in Jersey cows |
| title_sort | impact of genetic variants related to the fatty acid metabolic process pathway on milk production traits in jersey cows |
| topic | Milk fat content jersey breed genetic marker fatty acid biosynthesis |
| url | https://www.tandfonline.com/doi/10.1080/10495398.2024.2396421 |
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