Immunological Perspective: Helicobacter pylori Infection and Gastritis
Helicobacter pylori is a spiral-shaped gram-negative bacterium. Its infection is mainly transmitted via oral-oral and fecal-oral routes usually during early childhood. It can achieve persistent colonization by manipulating the host immune responses, which also causes mucosal damage and inflammation....
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2022/2944156 |
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| _version_ | 1832564489672720384 |
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| author | Hang Yang Bing Hu |
| author_facet | Hang Yang Bing Hu |
| author_sort | Hang Yang |
| collection | DOAJ |
| description | Helicobacter pylori is a spiral-shaped gram-negative bacterium. Its infection is mainly transmitted via oral-oral and fecal-oral routes usually during early childhood. It can achieve persistent colonization by manipulating the host immune responses, which also causes mucosal damage and inflammation. H. pylori gastritis is an infectious disease and results in chronic gastritis of different severity in near all patients with infection. It may develop from acute/chronic inflammation, chronic atrophic gastritis, intestinal metaplasia, dysplasia, and intraepithelial neoplasia, eventually to gastric cancer. This review attempts to cover recent studies which provide important insights into how H. pylori causes chronic inflammation and what the characteristic is, which will immunologically explain H. pylori gastritis. |
| format | Article |
| id | doaj-art-98aa23b1cbd84d98ad27e6bd179d34ff |
| institution | Kabale University |
| issn | 1466-1861 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-98aa23b1cbd84d98ad27e6bd179d34ff2025-02-03T01:10:58ZengWileyMediators of Inflammation1466-18612022-01-01202210.1155/2022/2944156Immunological Perspective: Helicobacter pylori Infection and GastritisHang Yang0Bing Hu1Department of GastroenterologyDepartment of GastroenterologyHelicobacter pylori is a spiral-shaped gram-negative bacterium. Its infection is mainly transmitted via oral-oral and fecal-oral routes usually during early childhood. It can achieve persistent colonization by manipulating the host immune responses, which also causes mucosal damage and inflammation. H. pylori gastritis is an infectious disease and results in chronic gastritis of different severity in near all patients with infection. It may develop from acute/chronic inflammation, chronic atrophic gastritis, intestinal metaplasia, dysplasia, and intraepithelial neoplasia, eventually to gastric cancer. This review attempts to cover recent studies which provide important insights into how H. pylori causes chronic inflammation and what the characteristic is, which will immunologically explain H. pylori gastritis.http://dx.doi.org/10.1155/2022/2944156 |
| spellingShingle | Hang Yang Bing Hu Immunological Perspective: Helicobacter pylori Infection and Gastritis Mediators of Inflammation |
| title | Immunological Perspective: Helicobacter pylori Infection and Gastritis |
| title_full | Immunological Perspective: Helicobacter pylori Infection and Gastritis |
| title_fullStr | Immunological Perspective: Helicobacter pylori Infection and Gastritis |
| title_full_unstemmed | Immunological Perspective: Helicobacter pylori Infection and Gastritis |
| title_short | Immunological Perspective: Helicobacter pylori Infection and Gastritis |
| title_sort | immunological perspective helicobacter pylori infection and gastritis |
| url | http://dx.doi.org/10.1155/2022/2944156 |
| work_keys_str_mv | AT hangyang immunologicalperspectivehelicobacterpyloriinfectionandgastritis AT binghu immunologicalperspectivehelicobacterpyloriinfectionandgastritis |