Platelet phenotypes and practical aspects of platelet function testing in cardiology
The assessment of platelet dysfunction is usually used by hematologists to diagnose inherited (such as Bernard-Soulier syndrome, platelet-type-von Willebrand disease, Glanzmann thrombasthenia, etc.), and acquired (symptomatic) platelet disorders (in hemoblastoses, uremia, liver cirrhosis, etc.), as...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Столичная издательская компания
2023-12-01
|
| Series: | Рациональная фармакотерапия в кардиологии |
| Subjects: | |
| Online Access: | https://www.rpcardio.online/jour/article/view/2981 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849227519151046656 |
|---|---|
| author | Zh. D. Kobalava A. S. Pisaryuk A. A. Filkova E. S. Tukhsanboev A. A. Boldyreva D. P. Lazutova I. A. Meray M. A. Panteleev |
| author_facet | Zh. D. Kobalava A. S. Pisaryuk A. A. Filkova E. S. Tukhsanboev A. A. Boldyreva D. P. Lazutova I. A. Meray M. A. Panteleev |
| author_sort | Zh. D. Kobalava |
| collection | DOAJ |
| description | The assessment of platelet dysfunction is usually used by hematologists to diagnose inherited (such as Bernard-Soulier syndrome, platelet-type-von Willebrand disease, Glanzmann thrombasthenia, etc.), and acquired (symptomatic) platelet disorders (in hemoblastoses, uremia, liver cirrhosis, etc.), as well as to predict the risk of intraoperative bleeding in these groups of patients. Later, laboratory platelet function tests began to be used by cardiologists, first in experimental and clinical studies. In further years, attempts were made to introduce them into clinical practice. Current data show association between platelet hyperreactivity and pathogenesis of cardiovascular events. At the same time, despite the various consensus papers on assessing thrombotic and bleeding risk, monitoring antiplatelet therapy, including those published by Russian experts, in practice there are many subtleties and questions about the practical aspects of using laboratory tests. In addition, the definition of platelet phenotype does not have a clear concept. The review purpose was to describe laboratory methods for assessing the platelet function, to give more information to cardiologists about its practical value and to understand what basic scientists and physicians mean by the term “platelet phenotype”. |
| format | Article |
| id | doaj-art-98a835eaf08d4fdebb56bc49667a31f8 |
| institution | Kabale University |
| issn | 1819-6446 2225-3653 |
| language | English |
| publishDate | 2023-12-01 |
| publisher | Столичная издательская компания |
| record_format | Article |
| series | Рациональная фармакотерапия в кардиологии |
| spelling | doaj-art-98a835eaf08d4fdebb56bc49667a31f82025-08-23T10:00:36ZengСтоличная издательская компанияРациональная фармакотерапия в кардиологии1819-64462225-36532023-12-0119661462810.20996/1819-6446-2023-29812173Platelet phenotypes and practical aspects of platelet function testing in cardiologyZh. D. Kobalava0A. S. Pisaryuk1A. A. Filkova2E. S. Tukhsanboev3A. A. Boldyreva4D. P. Lazutova5I. A. Meray6M. A. Panteleev7Peoples’ Friendship University of Russia; V. V. Vinogradov Moscow City HospitalPeoples’ Friendship University of Russia; V. V. Vinogradov Moscow City HospitalCenter for Theoretical Problems of Physicochemical Pharmacology; Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and ImmunologyPeoples’ Friendship University of Russia; V. V. Vinogradov Moscow City HospitalCenter for Theoretical Problems of Physicochemical Pharmacology; Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and ImmunologyCenter for Theoretical Problems of Physicochemical Pharmacology; Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and ImmunologyPeoples’ Friendship University of Russia; V. V. Vinogradov Moscow City HospitalCenter for Theoretical Problems of Physicochemical Pharmacology; Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and ImmunologyThe assessment of platelet dysfunction is usually used by hematologists to diagnose inherited (such as Bernard-Soulier syndrome, platelet-type-von Willebrand disease, Glanzmann thrombasthenia, etc.), and acquired (symptomatic) platelet disorders (in hemoblastoses, uremia, liver cirrhosis, etc.), as well as to predict the risk of intraoperative bleeding in these groups of patients. Later, laboratory platelet function tests began to be used by cardiologists, first in experimental and clinical studies. In further years, attempts were made to introduce them into clinical practice. Current data show association between platelet hyperreactivity and pathogenesis of cardiovascular events. At the same time, despite the various consensus papers on assessing thrombotic and bleeding risk, monitoring antiplatelet therapy, including those published by Russian experts, in practice there are many subtleties and questions about the practical aspects of using laboratory tests. In addition, the definition of platelet phenotype does not have a clear concept. The review purpose was to describe laboratory methods for assessing the platelet function, to give more information to cardiologists about its practical value and to understand what basic scientists and physicians mean by the term “platelet phenotype”.https://www.rpcardio.online/jour/article/view/2981platelet function testingplatelet functionplatelet hyperreactivityplatelet phenotypesaggregometryflow cytometryguided antiplatelet therapy |
| spellingShingle | Zh. D. Kobalava A. S. Pisaryuk A. A. Filkova E. S. Tukhsanboev A. A. Boldyreva D. P. Lazutova I. A. Meray M. A. Panteleev Platelet phenotypes and practical aspects of platelet function testing in cardiology Рациональная фармакотерапия в кардиологии platelet function testing platelet function platelet hyperreactivity platelet phenotypes aggregometry flow cytometry guided antiplatelet therapy |
| title | Platelet phenotypes and practical aspects of platelet function testing in cardiology |
| title_full | Platelet phenotypes and practical aspects of platelet function testing in cardiology |
| title_fullStr | Platelet phenotypes and practical aspects of platelet function testing in cardiology |
| title_full_unstemmed | Platelet phenotypes and practical aspects of platelet function testing in cardiology |
| title_short | Platelet phenotypes and practical aspects of platelet function testing in cardiology |
| title_sort | platelet phenotypes and practical aspects of platelet function testing in cardiology |
| topic | platelet function testing platelet function platelet hyperreactivity platelet phenotypes aggregometry flow cytometry guided antiplatelet therapy |
| url | https://www.rpcardio.online/jour/article/view/2981 |
| work_keys_str_mv | AT zhdkobalava plateletphenotypesandpracticalaspectsofplateletfunctiontestingincardiology AT aspisaryuk plateletphenotypesandpracticalaspectsofplateletfunctiontestingincardiology AT aafilkova plateletphenotypesandpracticalaspectsofplateletfunctiontestingincardiology AT estukhsanboev plateletphenotypesandpracticalaspectsofplateletfunctiontestingincardiology AT aaboldyreva plateletphenotypesandpracticalaspectsofplateletfunctiontestingincardiology AT dplazutova plateletphenotypesandpracticalaspectsofplateletfunctiontestingincardiology AT iameray plateletphenotypesandpracticalaspectsofplateletfunctiontestingincardiology AT mapanteleev plateletphenotypesandpracticalaspectsofplateletfunctiontestingincardiology |