Developmental Profiles of Mucosal Immunity in Pre-school Children
This study investigated the effect of attending pre-school on mucosal immunity. Children 3.5 to 5 years of age who attended pre-school were observed for a 10 month period. Demographic information was collected on previous childcare experiences, the home environment and clinical information relating...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2010/196785 |
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| author | Patricia Ewing Diana C. Otczyk Stefano Occhipinti Jennelle M. Kyd Maree Gleeson Allan W. Cripps |
| author_facet | Patricia Ewing Diana C. Otczyk Stefano Occhipinti Jennelle M. Kyd Maree Gleeson Allan W. Cripps |
| author_sort | Patricia Ewing |
| collection | DOAJ |
| description | This study investigated the effect of attending pre-school on mucosal immunity. Children 3.5 to 5 years of age who attended pre-school were observed for a 10 month period. Demographic information was collected on previous childcare experiences, the home environment and clinical information relating to the child and the family. A daily illness log was kept for each child. A multivariate longitudinal analysis of the relation between immunoglobulins in saliva and age, gender, childcare experience, pre-school exposure, number of siblings, environmental tobacco smoke (ETS), atopy and hospitalisation was conducted. There was a positive association of higher IgA levels with the winter season and with children being older than 4 years (𝑃<.001), having attended childcare prior to commencing pre-school (𝑃<.05), and having been exposed to ETS at home (𝑃<.05). Lower IgA levels were associated with being atopic (𝑃<.05). Higher IgG levels were associated with exposure to ETS (𝑃<.001), while lower levels were associated to having atopy. Higher IgM levels were associated with previous childcare experience (𝑃<.01) whilst having been hospitalised was associated with having low salivary IgM levels (𝑃<.01). Lagged analyses demonstrated that immunological parameters were affected by the number of respiratory infections in the preceding 2 months. |
| format | Article |
| id | doaj-art-989fca1d9bda4ddab588c71e3e6c1f08 |
| institution | OA Journals |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-989fca1d9bda4ddab588c71e3e6c1f082025-08-20T02:09:59ZengWileyClinical and Developmental Immunology1740-25221740-25302010-01-01201010.1155/2010/196785196785Developmental Profiles of Mucosal Immunity in Pre-school ChildrenPatricia Ewing0Diana C. Otczyk1Stefano Occhipinti2Jennelle M. Kyd3Maree Gleeson4Allan W. Cripps5Faculty of Health, University of Canberra, ACT, 2601, AustraliaGriffith Health Institute, School of Medicine, Griffith Health, Griffith University, Gold Coast, QLD, 4222, AustraliaGriffith Health Institute, School of Psychology, Griffith Health, Griffith University, Gold Coast, QLD, 4222, AustraliaCapricornia Centre for Mucosal Immunology, Central Queensland University, Rockhampton, QLD, 4702, AustraliaHunter Institute Medical Research, University of Newcastle, Newcastle, NSW, 2308, AustraliaGriffith Health Institute, School of Medicine, Griffith Health, Griffith University, Gold Coast, QLD, 4222, AustraliaThis study investigated the effect of attending pre-school on mucosal immunity. Children 3.5 to 5 years of age who attended pre-school were observed for a 10 month period. Demographic information was collected on previous childcare experiences, the home environment and clinical information relating to the child and the family. A daily illness log was kept for each child. A multivariate longitudinal analysis of the relation between immunoglobulins in saliva and age, gender, childcare experience, pre-school exposure, number of siblings, environmental tobacco smoke (ETS), atopy and hospitalisation was conducted. There was a positive association of higher IgA levels with the winter season and with children being older than 4 years (𝑃<.001), having attended childcare prior to commencing pre-school (𝑃<.05), and having been exposed to ETS at home (𝑃<.05). Lower IgA levels were associated with being atopic (𝑃<.05). Higher IgG levels were associated with exposure to ETS (𝑃<.001), while lower levels were associated to having atopy. Higher IgM levels were associated with previous childcare experience (𝑃<.01) whilst having been hospitalised was associated with having low salivary IgM levels (𝑃<.01). Lagged analyses demonstrated that immunological parameters were affected by the number of respiratory infections in the preceding 2 months.http://dx.doi.org/10.1155/2010/196785 |
| spellingShingle | Patricia Ewing Diana C. Otczyk Stefano Occhipinti Jennelle M. Kyd Maree Gleeson Allan W. Cripps Developmental Profiles of Mucosal Immunity in Pre-school Children Clinical and Developmental Immunology |
| title | Developmental Profiles of Mucosal Immunity in Pre-school Children |
| title_full | Developmental Profiles of Mucosal Immunity in Pre-school Children |
| title_fullStr | Developmental Profiles of Mucosal Immunity in Pre-school Children |
| title_full_unstemmed | Developmental Profiles of Mucosal Immunity in Pre-school Children |
| title_short | Developmental Profiles of Mucosal Immunity in Pre-school Children |
| title_sort | developmental profiles of mucosal immunity in pre school children |
| url | http://dx.doi.org/10.1155/2010/196785 |
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