Developmental Profiles of Mucosal Immunity in Pre-school Children
This study investigated the effect of attending pre-school on mucosal immunity. Children 3.5 to 5 years of age who attended pre-school were observed for a 10 month period. Demographic information was collected on previous childcare experiences, the home environment and clinical information relating...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2010-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2010/196785 |
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| Summary: | This study investigated the effect of attending pre-school on mucosal immunity. Children 3.5 to 5 years of age who attended pre-school were observed for a 10 month period. Demographic information was collected on previous childcare experiences, the home environment and clinical information relating to the child and the family. A daily illness log was kept for each child. A multivariate longitudinal analysis of the relation between immunoglobulins in saliva and age, gender, childcare experience, pre-school exposure, number of siblings, environmental tobacco smoke (ETS), atopy and hospitalisation was conducted. There was a positive association of higher IgA levels with the winter season and with children being older than 4 years (𝑃<.001), having attended childcare prior to commencing pre-school (𝑃<.05), and having been exposed to ETS at home (𝑃<.05). Lower IgA levels were associated with being atopic (𝑃<.05). Higher IgG levels were associated with exposure to ETS (𝑃<.001), while lower levels were associated to having atopy. Higher IgM levels were associated with previous childcare experience (𝑃<.01) whilst having been hospitalised was associated with having low salivary IgM levels (𝑃<.01). Lagged analyses demonstrated that immunological parameters were affected by the number of respiratory infections in the preceding 2 months. |
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| ISSN: | 1740-2522 1740-2530 |