Effects of GS-CA1 on nuclear envelope-associated early HIV-1 infection steps

Effects of GS-CA1 on nuclear envelope-associated early HIV-1 infection steps

The novel HIV-1 drugs GS-CA1 and the recently approved lenacapavir (GS-6207) target the viral structural protein capsid (CA). However, their multiple mechanisms of action have not been fully characterized. Here, we investigated the effects of GS-CA1 on the early stages of HIV-1 infection, specifical...

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Bibliographic Details
Main Authors: Amita Singh, Victor Fourcassié, Karen Cristine Gonçalves Dos Santos, Hocine Chelbi, Natacha Merindol, Arnaud Droit, Hugo Germain, Lionel Berthoux
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Virology
Subjects:
HIV-1
HIV-1 capsid
GS-CA1
mass spectrometry
nuclear pore complex
nuclear envelope
Online Access:https://www.frontiersin.org/articles/10.3389/fviro.2025.1547176/full
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