Multiple Factors Related to the Secretion of Glucagon-Like Peptide-1
The glucagon-like peptide-1 is secreted by intestinal L cells in response to nutrient ingestion. It regulates the secretion and sensitivity of insulin while suppressing glucagon secretion and decreasing postprandial glucose levels. It also improves beta-cell proliferation and prevents beta-cell apop...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2015/651757 |
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| author | XingChun Wang Huan Liu Jiaqi Chen Yan Li Shen Qu |
| author_facet | XingChun Wang Huan Liu Jiaqi Chen Yan Li Shen Qu |
| author_sort | XingChun Wang |
| collection | DOAJ |
| description | The glucagon-like peptide-1 is secreted by intestinal L cells in response to nutrient ingestion. It regulates the secretion and sensitivity of insulin while suppressing glucagon secretion and decreasing postprandial glucose levels. It also improves beta-cell proliferation and prevents beta-cell apoptosis induced by cytotoxic agents. Additionally, glucagon-like peptide-1 delays gastric emptying and suppresses appetite. The impaired secretion of glucagon-like peptide-1 has negative influence on diabetes, hyperlipidemia, and insulin resistance related diseases. Thus, glucagon-like peptide-1-based therapies (glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors) are now well accepted in the management of type 2 diabetes. The levels of glucagon-like peptide-1 are influenced by multiple factors including a variety of nutrients. The component of a meal acts as potent stimulants of glucagon-like peptide-1 secretion. The levels of its secretion change with the intake of different nutrients. Some drugs also have influence on GLP-1 secretion. Bariatric surgery may improve metabolism through the action on GLP-1 levels. In recent years, there has been a great interest in developing effective methods to regulate glucagon-like peptide-1 secretion. This review summarizes the literature on glucagon-like peptide-1 and related factors affecting its levels. |
| format | Article |
| id | doaj-art-988df14829364675904640741338c3e9 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-988df14829364675904640741338c3e92025-02-03T05:46:40ZengWileyInternational Journal of Endocrinology1687-83371687-83452015-01-01201510.1155/2015/651757651757Multiple Factors Related to the Secretion of Glucagon-Like Peptide-1XingChun Wang0Huan Liu1Jiaqi Chen2Yan Li3Shen Qu4Department of Endocrinology and Metabolism, Shanghai 10th People’s Hospital, Tongji University, Shanghai 200072, ChinaDepartment of Urology, Zhenjiang First People’s Hospital, Zhenjiang, Jiangsu 212002, ChinaDepartment of Endocrinology and Metabolism, Shanghai 10th People’s Hospital, Tongji University, Shanghai 200072, ChinaDepartment of Endocrinology and Metabolism, Shanghai 10th People’s Hospital, Tongji University, Shanghai 200072, ChinaDepartment of Endocrinology and Metabolism, Shanghai 10th People’s Hospital, Tongji University, Shanghai 200072, ChinaThe glucagon-like peptide-1 is secreted by intestinal L cells in response to nutrient ingestion. It regulates the secretion and sensitivity of insulin while suppressing glucagon secretion and decreasing postprandial glucose levels. It also improves beta-cell proliferation and prevents beta-cell apoptosis induced by cytotoxic agents. Additionally, glucagon-like peptide-1 delays gastric emptying and suppresses appetite. The impaired secretion of glucagon-like peptide-1 has negative influence on diabetes, hyperlipidemia, and insulin resistance related diseases. Thus, glucagon-like peptide-1-based therapies (glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors) are now well accepted in the management of type 2 diabetes. The levels of glucagon-like peptide-1 are influenced by multiple factors including a variety of nutrients. The component of a meal acts as potent stimulants of glucagon-like peptide-1 secretion. The levels of its secretion change with the intake of different nutrients. Some drugs also have influence on GLP-1 secretion. Bariatric surgery may improve metabolism through the action on GLP-1 levels. In recent years, there has been a great interest in developing effective methods to regulate glucagon-like peptide-1 secretion. This review summarizes the literature on glucagon-like peptide-1 and related factors affecting its levels.http://dx.doi.org/10.1155/2015/651757 |
| spellingShingle | XingChun Wang Huan Liu Jiaqi Chen Yan Li Shen Qu Multiple Factors Related to the Secretion of Glucagon-Like Peptide-1 International Journal of Endocrinology |
| title | Multiple Factors Related to the Secretion of Glucagon-Like Peptide-1 |
| title_full | Multiple Factors Related to the Secretion of Glucagon-Like Peptide-1 |
| title_fullStr | Multiple Factors Related to the Secretion of Glucagon-Like Peptide-1 |
| title_full_unstemmed | Multiple Factors Related to the Secretion of Glucagon-Like Peptide-1 |
| title_short | Multiple Factors Related to the Secretion of Glucagon-Like Peptide-1 |
| title_sort | multiple factors related to the secretion of glucagon like peptide 1 |
| url | http://dx.doi.org/10.1155/2015/651757 |
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