Advances in drug resistance and resistance mechanisms of four colorectal cancer-associated gut microbiota
Colorectal cancer (CRC) is a common malignant tumor in the gastrointestinal tract with inconspicuous early symptoms, high morbidity and mortality, and poor prognosis. Gut microbiota are present in the human intestinal system and have certain functions, which include the integrity of the epithelial b...
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PeerJ Inc.
2025-06-01
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| author | Yu Gan Hao Yang Maijian Wang Jida Li |
| author_facet | Yu Gan Hao Yang Maijian Wang Jida Li |
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| description | Colorectal cancer (CRC) is a common malignant tumor in the gastrointestinal tract with inconspicuous early symptoms, high morbidity and mortality, and poor prognosis. Gut microbiota are present in the human intestinal system and have certain functions, which include the integrity of the epithelial barrier and the enhancement of protective immune responses. The etiology of CRC is numerous and complex, including poor lifestyle and dietary habits, and instability of the gut microbiota, which is considered to be one of the major factors in the development of CRC, includes mainly Bacteroides fragilis, Fusobacterium nucleatum, Escherichia coli, and Enterococcus faecalis. Enrichment of these bacteria in CRC tumor tissues may increase other pro-inflammatory opportunistic pathogens and decrease butyrate-producing bacteria, leading to an imbalance in intestinal homeostasis (dysbiosis) and ultimately tumor formation. Antibiotic-induced changes in the gut microbiota affect tissue utilization and redox homeostasis of macronutrients and micronutrients. However, the long-term use and abuse of antibiotics has made the problem of drug resistance a difficult problem that currently plagues the regulation of gut microbiota, as well as a complicated issue in the prevention and treatment of CRC. In this review, we elucidated the drug resistance of four CRC-associated gut microbiota, namely Bacteroides fragilis, Fusobacterium nucleatum, Escherichia coli, and Enterococcus faecalis, and discussed the common and different aspects of the resistance mechanisms of the four gut microbiota, with the aim of providing a basis for the prevention and control of CRC. |
| format | Article |
| id | doaj-art-988d4da313c745d08ba9202d8bfda2d2 |
| institution | Kabale University |
| issn | 2167-8359 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | PeerJ Inc. |
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| spelling | doaj-art-988d4da313c745d08ba9202d8bfda2d22025-08-20T03:44:39ZengPeerJ Inc.PeerJ2167-83592025-06-0113e1953510.7717/peerj.19535Advances in drug resistance and resistance mechanisms of four colorectal cancer-associated gut microbiotaYu Gan0Hao Yang1Maijian Wang2Jida Li3Institute of Zoonosis, College of Public Health, Zunyi Medical University, Zunyi, Guizhou, ChinaXingyi City Disease Prevention and Control Center (Municipal Health Supervision Station), Xingyi, Guizhou, ChinaInstitute of Gastrointestinal, Affiliate Hospital of Zunyi Medical University, Zunyi, Guizhou, ChinaInstitute of Zoonosis, College of Public Health, Zunyi Medical University, Zunyi, Guizhou, ChinaColorectal cancer (CRC) is a common malignant tumor in the gastrointestinal tract with inconspicuous early symptoms, high morbidity and mortality, and poor prognosis. Gut microbiota are present in the human intestinal system and have certain functions, which include the integrity of the epithelial barrier and the enhancement of protective immune responses. The etiology of CRC is numerous and complex, including poor lifestyle and dietary habits, and instability of the gut microbiota, which is considered to be one of the major factors in the development of CRC, includes mainly Bacteroides fragilis, Fusobacterium nucleatum, Escherichia coli, and Enterococcus faecalis. Enrichment of these bacteria in CRC tumor tissues may increase other pro-inflammatory opportunistic pathogens and decrease butyrate-producing bacteria, leading to an imbalance in intestinal homeostasis (dysbiosis) and ultimately tumor formation. Antibiotic-induced changes in the gut microbiota affect tissue utilization and redox homeostasis of macronutrients and micronutrients. However, the long-term use and abuse of antibiotics has made the problem of drug resistance a difficult problem that currently plagues the regulation of gut microbiota, as well as a complicated issue in the prevention and treatment of CRC. In this review, we elucidated the drug resistance of four CRC-associated gut microbiota, namely Bacteroides fragilis, Fusobacterium nucleatum, Escherichia coli, and Enterococcus faecalis, and discussed the common and different aspects of the resistance mechanisms of the four gut microbiota, with the aim of providing a basis for the prevention and control of CRC.https://peerj.com/articles/19535.pdfColorectal cancerBacteroides fragilisFusobacterium nucleatumEnterotoxin-producing Escherichia coliEnterococcus faecalisDrug resistance mechanism |
| spellingShingle | Yu Gan Hao Yang Maijian Wang Jida Li Advances in drug resistance and resistance mechanisms of four colorectal cancer-associated gut microbiota PeerJ Colorectal cancer Bacteroides fragilis Fusobacterium nucleatum Enterotoxin-producing Escherichia coli Enterococcus faecalis Drug resistance mechanism |
| title | Advances in drug resistance and resistance mechanisms of four colorectal cancer-associated gut microbiota |
| title_full | Advances in drug resistance and resistance mechanisms of four colorectal cancer-associated gut microbiota |
| title_fullStr | Advances in drug resistance and resistance mechanisms of four colorectal cancer-associated gut microbiota |
| title_full_unstemmed | Advances in drug resistance and resistance mechanisms of four colorectal cancer-associated gut microbiota |
| title_short | Advances in drug resistance and resistance mechanisms of four colorectal cancer-associated gut microbiota |
| title_sort | advances in drug resistance and resistance mechanisms of four colorectal cancer associated gut microbiota |
| topic | Colorectal cancer Bacteroides fragilis Fusobacterium nucleatum Enterotoxin-producing Escherichia coli Enterococcus faecalis Drug resistance mechanism |
| url | https://peerj.com/articles/19535.pdf |
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