The gut–bone axis in osteoporosis: a multifaceted interaction with implications for bone health
With the accelerated aging of the population, degenerative orthopedic diseases, particularly osteoporosis, have become a major public health challenge, threatening bone health and affecting the quality of life. Existing anti-osteoporosis regimens remain rather unitary or poorly adhered, which also l...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-07-01
|
| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2025.1569152/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850105163608489984 |
|---|---|
| author | Chunli Gu Chunli Gu Hong Du Ningying Li Yunlong Zhou Sha Li Yuchen Sun Yiyang Han Xuan Xu Xianrong Li |
| author_facet | Chunli Gu Chunli Gu Hong Du Ningying Li Yunlong Zhou Sha Li Yuchen Sun Yiyang Han Xuan Xu Xianrong Li |
| author_sort | Chunli Gu |
| collection | DOAJ |
| description | With the accelerated aging of the population, degenerative orthopedic diseases, particularly osteoporosis, have become a major public health challenge, threatening bone health and affecting the quality of life. Existing anti-osteoporosis regimens remain rather unitary or poorly adhered, which also limits the maintenance of bone health to some extent. Given the increasingly elucidated prominence of gut-related factors in osteoblasts/osteoclasts and bone formation/metabolism/maintenance, focusing on intestinal microecology and then targeting the distal bone tissue via the gut–bone axis have been recognized as a feasible intervention strategy. This review systematically summarized the interaction of the gut–bone axis while highlighting the physicochemical barriers formed by intestinal intrinsic structures, the gut microbiota, and related molecules for bone health maintenance through the immune and endocrine pathways. Meanwhile, we emphasized the ideal anti-osteoporotic property and individual achievability of methods like fecal microbiota transplantation, probiotic and prebiotic supplementation, and dietary pattern modification. The conceptual framework of the gut–bone axis plus X was innovatively proposed, given the potential synergy among different organs in disease characterization and pathogenesis, which may help better explain the etiology and manage other co-morbidities concurrent with or secondary to osteoporosis. Since the intersection of orthopedics with other subjects, we also supported the application of nano-biomaterials, bacterial synthetic biology, and novel small molecules in anti-osteoporosis, which is expected to unlock broader prospects for the multidisciplinary integration of the gut–bone axis. |
| format | Article |
| id | doaj-art-988c114df8934106969d569e30faabd6 |
| institution | DOAJ |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj-art-988c114df8934106969d569e30faabd62025-08-20T02:39:09ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-07-011610.3389/fendo.2025.15691521569152The gut–bone axis in osteoporosis: a multifaceted interaction with implications for bone healthChunli Gu0Chunli Gu1Hong Du2Ningying Li3Yunlong Zhou4Sha Li5Yuchen Sun6Yiyang Han7Xuan Xu8Xianrong Li9School of Nursing, Southwest Medical University, Luzhou, Sichuan, ChinaDepartment of Orthopedics, The People’s Hospital of Leshan, Leshan, Sichuan, ChinaSchool of Clinical Medicine, Southwest Medical University, Luzhou, Sichuan, ChinaSchool of Nursing, Southwest Medical University, Luzhou, Sichuan, ChinaDepartment of Orthopedics, The People’s Hospital of Leshan, Leshan, Sichuan, ChinaDepartment of Orthopedics, The People’s Hospital of Leshan, Leshan, Sichuan, ChinaDepartment of Clinical Medicine, University of Hong Kong, Hongkong, Hongkong SAR, ChinaInstitute of Translational Medicine, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, ChinaInstitute of Translational Medicine, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, ChinaSchool of Nursing, Southwest Medical University, Luzhou, Sichuan, ChinaWith the accelerated aging of the population, degenerative orthopedic diseases, particularly osteoporosis, have become a major public health challenge, threatening bone health and affecting the quality of life. Existing anti-osteoporosis regimens remain rather unitary or poorly adhered, which also limits the maintenance of bone health to some extent. Given the increasingly elucidated prominence of gut-related factors in osteoblasts/osteoclasts and bone formation/metabolism/maintenance, focusing on intestinal microecology and then targeting the distal bone tissue via the gut–bone axis have been recognized as a feasible intervention strategy. This review systematically summarized the interaction of the gut–bone axis while highlighting the physicochemical barriers formed by intestinal intrinsic structures, the gut microbiota, and related molecules for bone health maintenance through the immune and endocrine pathways. Meanwhile, we emphasized the ideal anti-osteoporotic property and individual achievability of methods like fecal microbiota transplantation, probiotic and prebiotic supplementation, and dietary pattern modification. The conceptual framework of the gut–bone axis plus X was innovatively proposed, given the potential synergy among different organs in disease characterization and pathogenesis, which may help better explain the etiology and manage other co-morbidities concurrent with or secondary to osteoporosis. Since the intersection of orthopedics with other subjects, we also supported the application of nano-biomaterials, bacterial synthetic biology, and novel small molecules in anti-osteoporosis, which is expected to unlock broader prospects for the multidisciplinary integration of the gut–bone axis.https://www.frontiersin.org/articles/10.3389/fendo.2025.1569152/fullgut-bone axisosteoporosisgut microbiotaimmune and endocrine regulationorthopedic diseasesbone metabolism |
| spellingShingle | Chunli Gu Chunli Gu Hong Du Ningying Li Yunlong Zhou Sha Li Yuchen Sun Yiyang Han Xuan Xu Xianrong Li The gut–bone axis in osteoporosis: a multifaceted interaction with implications for bone health Frontiers in Endocrinology gut-bone axis osteoporosis gut microbiota immune and endocrine regulation orthopedic diseases bone metabolism |
| title | The gut–bone axis in osteoporosis: a multifaceted interaction with implications for bone health |
| title_full | The gut–bone axis in osteoporosis: a multifaceted interaction with implications for bone health |
| title_fullStr | The gut–bone axis in osteoporosis: a multifaceted interaction with implications for bone health |
| title_full_unstemmed | The gut–bone axis in osteoporosis: a multifaceted interaction with implications for bone health |
| title_short | The gut–bone axis in osteoporosis: a multifaceted interaction with implications for bone health |
| title_sort | gut bone axis in osteoporosis a multifaceted interaction with implications for bone health |
| topic | gut-bone axis osteoporosis gut microbiota immune and endocrine regulation orthopedic diseases bone metabolism |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2025.1569152/full |
| work_keys_str_mv | AT chunligu thegutboneaxisinosteoporosisamultifacetedinteractionwithimplicationsforbonehealth AT chunligu thegutboneaxisinosteoporosisamultifacetedinteractionwithimplicationsforbonehealth AT hongdu thegutboneaxisinosteoporosisamultifacetedinteractionwithimplicationsforbonehealth AT ningyingli thegutboneaxisinosteoporosisamultifacetedinteractionwithimplicationsforbonehealth AT yunlongzhou thegutboneaxisinosteoporosisamultifacetedinteractionwithimplicationsforbonehealth AT shali thegutboneaxisinosteoporosisamultifacetedinteractionwithimplicationsforbonehealth AT yuchensun thegutboneaxisinosteoporosisamultifacetedinteractionwithimplicationsforbonehealth AT yiyanghan thegutboneaxisinosteoporosisamultifacetedinteractionwithimplicationsforbonehealth AT xuanxu thegutboneaxisinosteoporosisamultifacetedinteractionwithimplicationsforbonehealth AT xianrongli thegutboneaxisinosteoporosisamultifacetedinteractionwithimplicationsforbonehealth AT chunligu gutboneaxisinosteoporosisamultifacetedinteractionwithimplicationsforbonehealth AT chunligu gutboneaxisinosteoporosisamultifacetedinteractionwithimplicationsforbonehealth AT hongdu gutboneaxisinosteoporosisamultifacetedinteractionwithimplicationsforbonehealth AT ningyingli gutboneaxisinosteoporosisamultifacetedinteractionwithimplicationsforbonehealth AT yunlongzhou gutboneaxisinosteoporosisamultifacetedinteractionwithimplicationsforbonehealth AT shali gutboneaxisinosteoporosisamultifacetedinteractionwithimplicationsforbonehealth AT yuchensun gutboneaxisinosteoporosisamultifacetedinteractionwithimplicationsforbonehealth AT yiyanghan gutboneaxisinosteoporosisamultifacetedinteractionwithimplicationsforbonehealth AT xuanxu gutboneaxisinosteoporosisamultifacetedinteractionwithimplicationsforbonehealth AT xianrongli gutboneaxisinosteoporosisamultifacetedinteractionwithimplicationsforbonehealth |