The Role of MicroRNAs in the Pathogenesis of Diabetic Nephropathy
Diabetic nephropathy (DN) is one of the most common microvascular complications in diabetic patients; it is also an important cause of renal dysfunction, renal fibrosis, and end-stage renal disease. Unfortunately, the pathogenesis of DN is complex and has not yet been fully elucidated; hence, the pa...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2019/8719060 |
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| _version_ | 1849403088540008448 |
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| author | Jian Tang Deyi Yao Haiying Yan Xing Chen Linjia Wang Huakui Zhan |
| author_facet | Jian Tang Deyi Yao Haiying Yan Xing Chen Linjia Wang Huakui Zhan |
| author_sort | Jian Tang |
| collection | DOAJ |
| description | Diabetic nephropathy (DN) is one of the most common microvascular complications in diabetic patients; it is also an important cause of renal dysfunction, renal fibrosis, and end-stage renal disease. Unfortunately, the pathogenesis of DN is complex and has not yet been fully elucidated; hence, the pathogenesis of DN to determine effective treatments of crucial importance is deeply explored. Early DN research focuses on hemodynamic changes and metabolic disorders, and recent studies have shown the regulatory role of microRNAs (miRNAs) in genes, which may be a new diagnostic marker and therapeutic target for diabetic nephropathy. In this review, we summarize the recent advances in the clinical value and molecular mechanisms of miRNAs in DN, providing new ideas for the diagnosis and treatment of DN. |
| format | Article |
| id | doaj-art-988b65a49de24a1c9fcab2f7fa28583e |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-988b65a49de24a1c9fcab2f7fa28583e2025-08-20T03:37:22ZengWileyInternational Journal of Endocrinology1687-83371687-83452019-01-01201910.1155/2019/87190608719060The Role of MicroRNAs in the Pathogenesis of Diabetic NephropathyJian Tang0Deyi Yao1Haiying Yan2Xing Chen3Linjia Wang4Huakui Zhan5Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan, ChinaChengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan, ChinaChengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan, ChinaChengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan, ChinaChengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan, ChinaHospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan, ChinaDiabetic nephropathy (DN) is one of the most common microvascular complications in diabetic patients; it is also an important cause of renal dysfunction, renal fibrosis, and end-stage renal disease. Unfortunately, the pathogenesis of DN is complex and has not yet been fully elucidated; hence, the pathogenesis of DN to determine effective treatments of crucial importance is deeply explored. Early DN research focuses on hemodynamic changes and metabolic disorders, and recent studies have shown the regulatory role of microRNAs (miRNAs) in genes, which may be a new diagnostic marker and therapeutic target for diabetic nephropathy. In this review, we summarize the recent advances in the clinical value and molecular mechanisms of miRNAs in DN, providing new ideas for the diagnosis and treatment of DN.http://dx.doi.org/10.1155/2019/8719060 |
| spellingShingle | Jian Tang Deyi Yao Haiying Yan Xing Chen Linjia Wang Huakui Zhan The Role of MicroRNAs in the Pathogenesis of Diabetic Nephropathy International Journal of Endocrinology |
| title | The Role of MicroRNAs in the Pathogenesis of Diabetic Nephropathy |
| title_full | The Role of MicroRNAs in the Pathogenesis of Diabetic Nephropathy |
| title_fullStr | The Role of MicroRNAs in the Pathogenesis of Diabetic Nephropathy |
| title_full_unstemmed | The Role of MicroRNAs in the Pathogenesis of Diabetic Nephropathy |
| title_short | The Role of MicroRNAs in the Pathogenesis of Diabetic Nephropathy |
| title_sort | role of micrornas in the pathogenesis of diabetic nephropathy |
| url | http://dx.doi.org/10.1155/2019/8719060 |
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