Urine Metabolomic Profiling and Machine Learning in Autism Spectrum Disorder Diagnosis: Toward Precision Treatment

Background: Autism spectrum disorder (ASD) diagnosis traditionally relies on behavioral assessments, which can be subjective and often lead to delayed identification. Recent advances in metabolomics and machine learning offer promising alternatives for more objective and precise diagnostic approache...

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Main Authors: Shula Shazman, Julie Carmel, Maxim Itkin, Sergey Malitsky, Monia Shalan, Eyal Soreq, Evan Elliott, Maya Lebow, Yael Kuperman
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Metabolites
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Online Access:https://www.mdpi.com/2218-1989/15/5/332
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author Shula Shazman
Julie Carmel
Maxim Itkin
Sergey Malitsky
Monia Shalan
Eyal Soreq
Evan Elliott
Maya Lebow
Yael Kuperman
author_facet Shula Shazman
Julie Carmel
Maxim Itkin
Sergey Malitsky
Monia Shalan
Eyal Soreq
Evan Elliott
Maya Lebow
Yael Kuperman
author_sort Shula Shazman
collection DOAJ
description Background: Autism spectrum disorder (ASD) diagnosis traditionally relies on behavioral assessments, which can be subjective and often lead to delayed identification. Recent advances in metabolomics and machine learning offer promising alternatives for more objective and precise diagnostic approaches. Methods: First-morning urine samples were collected from 52 children (32 with ASD and 20 neurotypical controls), aged 5.04 ± 1.87 and 5.50 ± 1.74 years, respectively. Using liquid chromatography-mass spectrometry (LC-MS), 293 metabolites were identified and categorized into 189 endogenous and 104 exogenous metabolites. Various machine learning classifiers (random forest, logistic regression, random tree, and naïve Bayes) were applied to differentiate ASD and control groups through 10-fold cross-validation. Results: The random forest classifier achieved 85% accuracy and an area under the curve (AUC) of 0.9 using all 293 metabolites. Classification based solely on endogenous metabolites yielded 85% accuracy and an AUC of 0.86, whereas using exogenous metabolites alone resulted in lower performance (71% accuracy and an AUC of 0.72). Conclusion: This study demonstrates the potential of urine metabolomic profiling, particularly endogenous metabolites, as a complementary diagnostic tool for ASD. The high classification accuracy highlights the feasibility of developing assistive diagnostic methods based on metabolite profiles, although further research is needed to link these profiles to specific behavioral characteristics and ASD subtypes.
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spelling doaj-art-9884e80b483d4b9c822c49fb647a9cfa2025-08-20T02:33:55ZengMDPI AGMetabolites2218-19892025-05-0115533210.3390/metabo15050332Urine Metabolomic Profiling and Machine Learning in Autism Spectrum Disorder Diagnosis: Toward Precision TreatmentShula Shazman0Julie Carmel1Maxim Itkin2Sergey Malitsky3Monia Shalan4Eyal Soreq5Evan Elliott6Maya Lebow7Yael Kuperman8Department of Mathematics and Computer Science, The Open University of Israel, Raanana 4353701, IsraelAzrieli Faculty of Medicine, Bar Ilan University, Safed 1311502, IsraelMetabolic Profiling Unit, Life Sciences Core Facilities, Weizmann Institute of Science, Rehovot 7610001, IsraelMetabolic Profiling Unit, Life Sciences Core Facilities, Weizmann Institute of Science, Rehovot 7610001, IsraelZiv Medical Center, Safed 1311502, IsraelDepartment of Brain Science, Faculty of Medicine, Imperial College London, London SW3 6LY, UKAzrieli Faculty of Medicine, Bar Ilan University, Safed 1311502, IsraelANeustart, Ltd., Rishon LeZion 7526088, IsraelANeustart, Ltd., Rishon LeZion 7526088, IsraelBackground: Autism spectrum disorder (ASD) diagnosis traditionally relies on behavioral assessments, which can be subjective and often lead to delayed identification. Recent advances in metabolomics and machine learning offer promising alternatives for more objective and precise diagnostic approaches. Methods: First-morning urine samples were collected from 52 children (32 with ASD and 20 neurotypical controls), aged 5.04 ± 1.87 and 5.50 ± 1.74 years, respectively. Using liquid chromatography-mass spectrometry (LC-MS), 293 metabolites were identified and categorized into 189 endogenous and 104 exogenous metabolites. Various machine learning classifiers (random forest, logistic regression, random tree, and naïve Bayes) were applied to differentiate ASD and control groups through 10-fold cross-validation. Results: The random forest classifier achieved 85% accuracy and an area under the curve (AUC) of 0.9 using all 293 metabolites. Classification based solely on endogenous metabolites yielded 85% accuracy and an AUC of 0.86, whereas using exogenous metabolites alone resulted in lower performance (71% accuracy and an AUC of 0.72). Conclusion: This study demonstrates the potential of urine metabolomic profiling, particularly endogenous metabolites, as a complementary diagnostic tool for ASD. The high classification accuracy highlights the feasibility of developing assistive diagnostic methods based on metabolite profiles, although further research is needed to link these profiles to specific behavioral characteristics and ASD subtypes.https://www.mdpi.com/2218-1989/15/5/332autism spectrum disordermetabolomicsurine metabolitesmachine learningdiagnostic biomarkersrandom forest
spellingShingle Shula Shazman
Julie Carmel
Maxim Itkin
Sergey Malitsky
Monia Shalan
Eyal Soreq
Evan Elliott
Maya Lebow
Yael Kuperman
Urine Metabolomic Profiling and Machine Learning in Autism Spectrum Disorder Diagnosis: Toward Precision Treatment
Metabolites
autism spectrum disorder
metabolomics
urine metabolites
machine learning
diagnostic biomarkers
random forest
title Urine Metabolomic Profiling and Machine Learning in Autism Spectrum Disorder Diagnosis: Toward Precision Treatment
title_full Urine Metabolomic Profiling and Machine Learning in Autism Spectrum Disorder Diagnosis: Toward Precision Treatment
title_fullStr Urine Metabolomic Profiling and Machine Learning in Autism Spectrum Disorder Diagnosis: Toward Precision Treatment
title_full_unstemmed Urine Metabolomic Profiling and Machine Learning in Autism Spectrum Disorder Diagnosis: Toward Precision Treatment
title_short Urine Metabolomic Profiling and Machine Learning in Autism Spectrum Disorder Diagnosis: Toward Precision Treatment
title_sort urine metabolomic profiling and machine learning in autism spectrum disorder diagnosis toward precision treatment
topic autism spectrum disorder
metabolomics
urine metabolites
machine learning
diagnostic biomarkers
random forest
url https://www.mdpi.com/2218-1989/15/5/332
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