Refractory chronic lymphocytic leukemia with concomitant extramedullary multiple myeloma with lymph node involvement
Concomitant chronic lymphocytic leukemia (CLL) and multiple myeloma (MM) in the same patient is extremely rare. In this report, we present an unprecedented case of a patient with a history of progressive, purine analog-resistant CLL, who developed extramedullary malignant plasmacytic infiltrates in...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-12-01
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| Series: | Current Problems in Cancer: Case Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666621924000474 |
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| author | Piotr Jachimowski Łukasz Ciulkiewicz Bogna Ziarkiewicz-Wróblewska Laretta Grabowska-Derlatka Grzegorz Basak Mateusz Ziarkiewicz |
| author_facet | Piotr Jachimowski Łukasz Ciulkiewicz Bogna Ziarkiewicz-Wróblewska Laretta Grabowska-Derlatka Grzegorz Basak Mateusz Ziarkiewicz |
| author_sort | Piotr Jachimowski |
| collection | DOAJ |
| description | Concomitant chronic lymphocytic leukemia (CLL) and multiple myeloma (MM) in the same patient is extremely rare. In this report, we present an unprecedented case of a patient with a history of progressive, purine analog-resistant CLL, who developed extramedullary malignant plasmacytic infiltrates in lymph nodes on the background of preexisting CLL lesions, presenting with clinical sequelae attributable to active MM (hypercalcemia, renal insufficiency, anemia, bone lesions). We administered R-CHOP with bortezomib with partial remission and both CLL and MM relapsed after one month. Our patient deceased three months later. Surprisingly first bone marrow trephine biopsy did not reveal plasmacytic infiltration. However combination of symptoms presented by our patient should always be an indication for repeating biopsy. Early detection of aggressive multiple myeloma can improve prognosis and prolong survival. |
| format | Article |
| id | doaj-art-987fe5b017ec46fc9ba9686e73dae80d |
| institution | OA Journals |
| issn | 2666-6219 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Current Problems in Cancer: Case Reports |
| spelling | doaj-art-987fe5b017ec46fc9ba9686e73dae80d2025-08-20T02:17:59ZengElsevierCurrent Problems in Cancer: Case Reports2666-62192024-12-011610032410.1016/j.cpccr.2024.100324Refractory chronic lymphocytic leukemia with concomitant extramedullary multiple myeloma with lymph node involvementPiotr Jachimowski0Łukasz Ciulkiewicz1Bogna Ziarkiewicz-Wróblewska2Laretta Grabowska-Derlatka3Grzegorz Basak4Mateusz Ziarkiewicz5Department of Hematology, Transplantology and Internal Diseases, Medical University of Warsaw, Warsaw, PolandDepartment of Hematology, Transplantology and Internal Diseases, Medical University of Warsaw, Warsaw, PolandDepartment of Pathomorphology, Medical University of Warsaw, Warsaw, PolandDepartment of Radiology, Medical University of Warsaw, Warsaw, PolandDepartment of Hematology, Transplantology and Internal Diseases, Medical University of Warsaw, Warsaw, PolandDepartment of Hematology, Transplantology and Internal Diseases, Medical University of Warsaw, Warsaw, Poland; Corresponding author: Mateusz Ziarkiewicz, Department of Hematology, Transplantology and Internal Diseases, Medical University of Warsaw, 02-097 Warsaw, ul. Banacha 1A, Poland.Concomitant chronic lymphocytic leukemia (CLL) and multiple myeloma (MM) in the same patient is extremely rare. In this report, we present an unprecedented case of a patient with a history of progressive, purine analog-resistant CLL, who developed extramedullary malignant plasmacytic infiltrates in lymph nodes on the background of preexisting CLL lesions, presenting with clinical sequelae attributable to active MM (hypercalcemia, renal insufficiency, anemia, bone lesions). We administered R-CHOP with bortezomib with partial remission and both CLL and MM relapsed after one month. Our patient deceased three months later. Surprisingly first bone marrow trephine biopsy did not reveal plasmacytic infiltration. However combination of symptoms presented by our patient should always be an indication for repeating biopsy. Early detection of aggressive multiple myeloma can improve prognosis and prolong survival.http://www.sciencedirect.com/science/article/pii/S2666621924000474MM, CLL, Secondary malignancy, Prolymphocytic progressionNodal plasmacytoma |
| spellingShingle | Piotr Jachimowski Łukasz Ciulkiewicz Bogna Ziarkiewicz-Wróblewska Laretta Grabowska-Derlatka Grzegorz Basak Mateusz Ziarkiewicz Refractory chronic lymphocytic leukemia with concomitant extramedullary multiple myeloma with lymph node involvement Current Problems in Cancer: Case Reports MM, CLL, Secondary malignancy, Prolymphocytic progression Nodal plasmacytoma |
| title | Refractory chronic lymphocytic leukemia with concomitant extramedullary multiple myeloma with lymph node involvement |
| title_full | Refractory chronic lymphocytic leukemia with concomitant extramedullary multiple myeloma with lymph node involvement |
| title_fullStr | Refractory chronic lymphocytic leukemia with concomitant extramedullary multiple myeloma with lymph node involvement |
| title_full_unstemmed | Refractory chronic lymphocytic leukemia with concomitant extramedullary multiple myeloma with lymph node involvement |
| title_short | Refractory chronic lymphocytic leukemia with concomitant extramedullary multiple myeloma with lymph node involvement |
| title_sort | refractory chronic lymphocytic leukemia with concomitant extramedullary multiple myeloma with lymph node involvement |
| topic | MM, CLL, Secondary malignancy, Prolymphocytic progression Nodal plasmacytoma |
| url | http://www.sciencedirect.com/science/article/pii/S2666621924000474 |
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