Chinese herbal medicine (Rupi Sanjie capsule) for the treatment of breast pain: A systematic review and meta-analysis of randomized clinical trials
Background: Breast pain is one of the most common breast disorders, affecting 41%–69% women in the clinical populations. Chinese herbal medicine (Rupi Sanjie, RPSJ) capsule has been recommended to be commonly used for breast pain in China. This review aimed to systematically collect latest evidence...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2021-06-01
|
| Series: | Integrative Medicine Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213422020301232 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850209538899181568 |
|---|---|
| author | Bao-Yong Lai Li-Yan Jia Bo-Wen Yu Shi-Bing Liang Ai-Jing Chu Hui-Juan Cao Jian-Ping Liu Xiao-Hua Pei |
| author_facet | Bao-Yong Lai Li-Yan Jia Bo-Wen Yu Shi-Bing Liang Ai-Jing Chu Hui-Juan Cao Jian-Ping Liu Xiao-Hua Pei |
| author_sort | Bao-Yong Lai |
| collection | DOAJ |
| description | Background: Breast pain is one of the most common breast disorders, affecting 41%–69% women in the clinical populations. Chinese herbal medicine (Rupi Sanjie, RPSJ) capsule has been recommended to be commonly used for breast pain in China. This review aimed to systematically collect latest evidence and critically evaluate the eff ;ectiveness and safety of RPSJ capsule for breast pain. Methods: We searched 6 databases from their inception to June 1, 2020 for randomized clinical trials (RCTs) comparing RPSJ capsule with conventional drug therapies, placebo or no treatment. Primary outcomes were breast pain relief, reduction of breast mass and clinical cure rate. Results: Seventeen RCTs were included in total, involving 2899 participants with breast pain. RPSJ capsule showed a significant effects in shortening duration of the breast pain (MD-6.51 days, 95%CI [-8.57, -4.45], n = 82, 1 trial), shortening the duration of breast mass (MD-5.17 days, 95%CI [-7.56, -2.78], n = 82, 1 trial), improving clinical cure rate (RR 1.55, 95% CI [1.21, 2.00], I² = 64%, n = 1398, 10 trials) and total effective rate (RR 1.08, 95% CI [1.03, 1.14], I² = 71%, n = 2170, 14 trials) compared to Tamoxifen (TAM). The meta-analysis showed that the incidence of total adverse events was higher in TAM group than the RPSJ capsule group (RR 0.30, 95%CI [0.21, 0.42], I² = 49%, n = 2122, 13 trials). Conclusions: RPSJ capsule appears to be a potentially effective in treating breast pain and seems generally safe for clinical application. However, this potential benefit is inconclusive due to generally weak evidence, and the findings should be further confirmed in large and rigorous trials. |
| format | Article |
| id | doaj-art-987d911a137648d49b7e39f59eafdb66 |
| institution | OA Journals |
| issn | 2213-4220 |
| language | English |
| publishDate | 2021-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Integrative Medicine Research |
| spelling | doaj-art-987d911a137648d49b7e39f59eafdb662025-08-20T02:09:59ZengElsevierIntegrative Medicine Research2213-42202021-06-0110210049110.1016/j.imr.2020.100491Chinese herbal medicine (Rupi Sanjie capsule) for the treatment of breast pain: A systematic review and meta-analysis of randomized clinical trialsBao-Yong Lai0Li-Yan Jia1Bo-Wen Yu2Shi-Bing Liang3Ai-Jing Chu4Hui-Juan Cao5Jian-Ping Liu6Xiao-Hua Pei7Third Affiliated Hospital of Beijing University of Chinese Medicine, Beijing, ChinaSchool of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, ChinaThird Affiliated Hospital of Beijing University of Chinese Medicine, Beijing, ChinaCentre for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing, ChinaThird Affiliated Hospital of Beijing University of Chinese Medicine, Beijing, ChinaCentre for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing, ChinaCentre for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing, ChinaThird Affiliated Hospital of Beijing University of Chinese Medicine, Beijing, China; The Fangshan Hospital of Beijing Universality of Chinese Medicine, Beijing, China; Corresponding author at: Third Affiliated Hospital of Beijing University of Chinese Medicine, Beijing, China.Background: Breast pain is one of the most common breast disorders, affecting 41%–69% women in the clinical populations. Chinese herbal medicine (Rupi Sanjie, RPSJ) capsule has been recommended to be commonly used for breast pain in China. This review aimed to systematically collect latest evidence and critically evaluate the eff ;ectiveness and safety of RPSJ capsule for breast pain. Methods: We searched 6 databases from their inception to June 1, 2020 for randomized clinical trials (RCTs) comparing RPSJ capsule with conventional drug therapies, placebo or no treatment. Primary outcomes were breast pain relief, reduction of breast mass and clinical cure rate. Results: Seventeen RCTs were included in total, involving 2899 participants with breast pain. RPSJ capsule showed a significant effects in shortening duration of the breast pain (MD-6.51 days, 95%CI [-8.57, -4.45], n = 82, 1 trial), shortening the duration of breast mass (MD-5.17 days, 95%CI [-7.56, -2.78], n = 82, 1 trial), improving clinical cure rate (RR 1.55, 95% CI [1.21, 2.00], I² = 64%, n = 1398, 10 trials) and total effective rate (RR 1.08, 95% CI [1.03, 1.14], I² = 71%, n = 2170, 14 trials) compared to Tamoxifen (TAM). The meta-analysis showed that the incidence of total adverse events was higher in TAM group than the RPSJ capsule group (RR 0.30, 95%CI [0.21, 0.42], I² = 49%, n = 2122, 13 trials). Conclusions: RPSJ capsule appears to be a potentially effective in treating breast pain and seems generally safe for clinical application. However, this potential benefit is inconclusive due to generally weak evidence, and the findings should be further confirmed in large and rigorous trials.http://www.sciencedirect.com/science/article/pii/S2213422020301232Herbal medicineBreast painRandomized controlled trialSystematic reviewMeta-Analysis |
| spellingShingle | Bao-Yong Lai Li-Yan Jia Bo-Wen Yu Shi-Bing Liang Ai-Jing Chu Hui-Juan Cao Jian-Ping Liu Xiao-Hua Pei Chinese herbal medicine (Rupi Sanjie capsule) for the treatment of breast pain: A systematic review and meta-analysis of randomized clinical trials Integrative Medicine Research Herbal medicine Breast pain Randomized controlled trial Systematic review Meta-Analysis |
| title | Chinese herbal medicine (Rupi Sanjie capsule) for the treatment of breast pain: A systematic review and meta-analysis of randomized clinical trials |
| title_full | Chinese herbal medicine (Rupi Sanjie capsule) for the treatment of breast pain: A systematic review and meta-analysis of randomized clinical trials |
| title_fullStr | Chinese herbal medicine (Rupi Sanjie capsule) for the treatment of breast pain: A systematic review and meta-analysis of randomized clinical trials |
| title_full_unstemmed | Chinese herbal medicine (Rupi Sanjie capsule) for the treatment of breast pain: A systematic review and meta-analysis of randomized clinical trials |
| title_short | Chinese herbal medicine (Rupi Sanjie capsule) for the treatment of breast pain: A systematic review and meta-analysis of randomized clinical trials |
| title_sort | chinese herbal medicine rupi sanjie capsule for the treatment of breast pain a systematic review and meta analysis of randomized clinical trials |
| topic | Herbal medicine Breast pain Randomized controlled trial Systematic review Meta-Analysis |
| url | http://www.sciencedirect.com/science/article/pii/S2213422020301232 |
| work_keys_str_mv | AT baoyonglai chineseherbalmedicinerupisanjiecapsuleforthetreatmentofbreastpainasystematicreviewandmetaanalysisofrandomizedclinicaltrials AT liyanjia chineseherbalmedicinerupisanjiecapsuleforthetreatmentofbreastpainasystematicreviewandmetaanalysisofrandomizedclinicaltrials AT bowenyu chineseherbalmedicinerupisanjiecapsuleforthetreatmentofbreastpainasystematicreviewandmetaanalysisofrandomizedclinicaltrials AT shibingliang chineseherbalmedicinerupisanjiecapsuleforthetreatmentofbreastpainasystematicreviewandmetaanalysisofrandomizedclinicaltrials AT aijingchu chineseherbalmedicinerupisanjiecapsuleforthetreatmentofbreastpainasystematicreviewandmetaanalysisofrandomizedclinicaltrials AT huijuancao chineseherbalmedicinerupisanjiecapsuleforthetreatmentofbreastpainasystematicreviewandmetaanalysisofrandomizedclinicaltrials AT jianpingliu chineseherbalmedicinerupisanjiecapsuleforthetreatmentofbreastpainasystematicreviewandmetaanalysisofrandomizedclinicaltrials AT xiaohuapei chineseherbalmedicinerupisanjiecapsuleforthetreatmentofbreastpainasystematicreviewandmetaanalysisofrandomizedclinicaltrials |