The Role of Leptin in Antipsychotic-Induced Weight Gain: Genetic and Non-Genetic Factors
Schizophrenia is a chronic and disabling mental illness affecting millions of people worldwide. A greater proportion of people with schizophrenia tends to be overweight. Antipsychotic medications have been considered the primary risk factor for obesity in schizophrenia, although the mechanisms by wh...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Journal of Obesity |
| Online Access: | http://dx.doi.org/10.1155/2012/572848 |
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| author | Fabio Panariello Gina Polsinelli Carol Borlido Marcellino Monda Vincenzo De Luca |
| author_facet | Fabio Panariello Gina Polsinelli Carol Borlido Marcellino Monda Vincenzo De Luca |
| author_sort | Fabio Panariello |
| collection | DOAJ |
| description | Schizophrenia is a chronic and disabling mental illness affecting millions of people worldwide. A greater proportion of people with schizophrenia tends to be overweight. Antipsychotic medications have been considered the primary risk factor for obesity in schizophrenia, although the mechanisms by which they increase weight and produce metabolic disturbances are unclear. Several lines of research indicate that leptin could be a good candidate involved in pathways linking antipsychotic treatment and weight gain. Leptin is a circulating hormone released by adipocytes in response to increased fat deposition to regulate body weight, acting through receptors in the hypothalamus. In this work, we reviewed preclinical, clinical, and genetic data in order to infer the potential role played by leptin in antipsychotic-induced weight gain considering two main hypotheses: (1) leptin is an epiphenomenon of weight gain; (2) leptin is a consequence of antipsychotic-induced “leptin-resistance status,” causing weight gain. |
| format | Article |
| id | doaj-art-987b8c8f809d449c9bbc45864bea70f6 |
| institution | Kabale University |
| issn | 2090-0708 2090-0716 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Obesity |
| spelling | doaj-art-987b8c8f809d449c9bbc45864bea70f62025-02-03T07:25:32ZengWileyJournal of Obesity2090-07082090-07162012-01-01201210.1155/2012/572848572848The Role of Leptin in Antipsychotic-Induced Weight Gain: Genetic and Non-Genetic FactorsFabio Panariello0Gina Polsinelli1Carol Borlido2Marcellino Monda3Vincenzo De Luca4Spedali Civili Brescia, Department Mental Health, 25123 Brescia, ItalyCentre for Addiction and Mental Health, room 30, 250 College street, Toronto, ON, M5T 1R8, CanadaCentre for Addiction and Mental Health, room 30, 250 College street, Toronto, ON, M5T 1R8, CanadaDipartimento di Medicina Sperimentale, Seconda Università degli Studi di Napoli, 80131 Napoli, ItalyCentre for Addiction and Mental Health, room 30, 250 College street, Toronto, ON, M5T 1R8, CanadaSchizophrenia is a chronic and disabling mental illness affecting millions of people worldwide. A greater proportion of people with schizophrenia tends to be overweight. Antipsychotic medications have been considered the primary risk factor for obesity in schizophrenia, although the mechanisms by which they increase weight and produce metabolic disturbances are unclear. Several lines of research indicate that leptin could be a good candidate involved in pathways linking antipsychotic treatment and weight gain. Leptin is a circulating hormone released by adipocytes in response to increased fat deposition to regulate body weight, acting through receptors in the hypothalamus. In this work, we reviewed preclinical, clinical, and genetic data in order to infer the potential role played by leptin in antipsychotic-induced weight gain considering two main hypotheses: (1) leptin is an epiphenomenon of weight gain; (2) leptin is a consequence of antipsychotic-induced “leptin-resistance status,” causing weight gain.http://dx.doi.org/10.1155/2012/572848 |
| spellingShingle | Fabio Panariello Gina Polsinelli Carol Borlido Marcellino Monda Vincenzo De Luca The Role of Leptin in Antipsychotic-Induced Weight Gain: Genetic and Non-Genetic Factors Journal of Obesity |
| title | The Role of Leptin in Antipsychotic-Induced Weight Gain: Genetic and Non-Genetic Factors |
| title_full | The Role of Leptin in Antipsychotic-Induced Weight Gain: Genetic and Non-Genetic Factors |
| title_fullStr | The Role of Leptin in Antipsychotic-Induced Weight Gain: Genetic and Non-Genetic Factors |
| title_full_unstemmed | The Role of Leptin in Antipsychotic-Induced Weight Gain: Genetic and Non-Genetic Factors |
| title_short | The Role of Leptin in Antipsychotic-Induced Weight Gain: Genetic and Non-Genetic Factors |
| title_sort | role of leptin in antipsychotic induced weight gain genetic and non genetic factors |
| url | http://dx.doi.org/10.1155/2012/572848 |
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