ABCG2 protein expression in tumors of patients with non-resectable pancreatic cancer treated with gemcitabine and nab-paclitaxel

ABCG2 protein expression in tumors of patients with non-resectable pancreatic cancer treated with gemcitabine and nab-paclitaxel

BackgroundATP-binding cassette (ABC) proteins are transmembrane efflux pumps that play a role in Multi Drug Resistance. ABCG2 and ABCB1 have been suggested as important mediators of resistance to chemotherapy (CTx) in pancreatic cancer (PC). We determined the expression of ABCG2 and ABCB1 proteins i...

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Bibliographic Details
Main Authors: Susy Shim, Mette Bak Nielsen, Mikkel Eld, Jan Stenvang, Rasmus Froberg Brøndum, Britta Weber, Anne Krejbjerg Motavaf, Morten Ladekarl
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Oncology
Subjects:
gemcitabine
nab-paclitaxel
ATP-binding cassette protein
ABCG2
BRCP
chemotherapy resistance
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1558184/full
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