Dihydrotestosterone and 17β-estradiol modulate TMJ osteoarthritis development and reveal sex-specific differences in pathogenesis

Dihydrotestosterone and 17β-estradiol modulate TMJ osteoarthritis development and reveal sex-specific differences in pathogenesis

Abstract To investigate the effects and mechanisms of dihydrotestosterone (DHT) and 17β-estradiol on temporomandibular joint osteoarthritis (TMJ-OA) to understand sex differences and apply findings to TMJ-OA prevention and treatment. Ten-week-old male C57BL/6J mice were divided into six groups to st...

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Bibliographic Details
Main Authors: Takuma Tomura, Takenobu Ishii, Norio Kasahara, Yasushi Nishii
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Temporomandibular joint
Osteoarthritis
17β-Estradiol
Dihydrotestosterone
Aromatase
Mechanical stress
Online Access:https://doi.org/10.1038/s41598-025-03475-w
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