Relationship between dietary inflammatory index and metabolic dysfunction associated steatotic liver disease in children
Abstract Emerging research suggests a connection between dietary habits and metabolic dysfunction associated steatotic liver disease (MASLD). We aimed to assess the relationship between the Dietary Inflammatory Index (DII) and the severity of MASLD. This cross-sectional study involved 125 participan...
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Nature Portfolio
2025-02-01
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| Online Access: | https://doi.org/10.1038/s41598-025-89690-x |
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| author | Fateme Amiri Jalal Moludi Touraj Ahmadi Jouybari Mahmoud Ghasemi Maryam Sharifi Behzad Mahaki Davood Soleimani |
| author_facet | Fateme Amiri Jalal Moludi Touraj Ahmadi Jouybari Mahmoud Ghasemi Maryam Sharifi Behzad Mahaki Davood Soleimani |
| author_sort | Fateme Amiri |
| collection | DOAJ |
| description | Abstract Emerging research suggests a connection between dietary habits and metabolic dysfunction associated steatotic liver disease (MASLD). We aimed to assess the relationship between the Dietary Inflammatory Index (DII) and the severity of MASLD. This cross-sectional study involved 125 participants aged 7–18 with MASLD. Dietary intakes were assessed using a validated 147-item food frequency questionnaire. The DII was applied to measure diet-induced inflammation, categorizing diets into anti-inflammatory (DII < -1) and inflammatory diets (DII > + 1). To evaluate hepatic steatosis and fibrosis, transabdominal ultrasonography and the fibrosis-4 (FIB-4) index were utilized. After adjusting for potential confounding factors, individuals on inflammatory diets exhibited a significantly higher odds ratio (OR) for experiencing more severe steatosis (OR: 4.11; 95% CI: 1.08–15.71) compared to those on anti-inflammatory diets. Furthermore, each unit increase in DII scores was linked to a 2.6-fold increase in the odds of more severe steatosis (OR: 2.61; 95% CI: 1.28–5.32) and a 0.006 increase in FIB-4 scores (β: 0.006; 95% CI: 0.003–0.011). In conclusion, modifying dietary intakes to lower DII scores may be a beneficial approach to improving clinical outcomes in pediatric MASLD, as anti-inflammatory diets are associated with reduced severity of hepatic steatosis and fibrosis. |
| format | Article |
| id | doaj-art-98656cdfa05b45debf10560a7c4c187d |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-02-01 |
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| spelling | doaj-art-98656cdfa05b45debf10560a7c4c187d2025-08-20T03:52:19ZengNature PortfolioScientific Reports2045-23222025-02-0115111010.1038/s41598-025-89690-xRelationship between dietary inflammatory index and metabolic dysfunction associated steatotic liver disease in childrenFateme Amiri0Jalal Moludi1Touraj Ahmadi Jouybari2Mahmoud Ghasemi3Maryam Sharifi4Behzad Mahaki5Davood Soleimani6Department of Nutritional Sciences, School of Nutritional Sciences and Food Technology, Kermanshah University of Medical SciencesDepartment of Nutritional Sciences, School of Nutritional Sciences and Food Technology, Kermanshah University of Medical SciencesClinical Research Development Center, Imam Khomeini and Mohammad Kermanshahi and Farabi Hospitals, Kermanshah University of Medical SciencesDepartment of Pediatrics, School of Medicine, Kermanshah University of Medical SciencesDepartment of Nutritional Sciences, School of Nutritional Sciences and Food Technology, Kermanshah University of Medical SciencesDepartment of Biostatistics, School of Health, Kermanshah University of Medical SciencesDepartment of Nutritional Sciences, School of Nutritional Sciences and Food Technology, Kermanshah University of Medical SciencesAbstract Emerging research suggests a connection between dietary habits and metabolic dysfunction associated steatotic liver disease (MASLD). We aimed to assess the relationship between the Dietary Inflammatory Index (DII) and the severity of MASLD. This cross-sectional study involved 125 participants aged 7–18 with MASLD. Dietary intakes were assessed using a validated 147-item food frequency questionnaire. The DII was applied to measure diet-induced inflammation, categorizing diets into anti-inflammatory (DII < -1) and inflammatory diets (DII > + 1). To evaluate hepatic steatosis and fibrosis, transabdominal ultrasonography and the fibrosis-4 (FIB-4) index were utilized. After adjusting for potential confounding factors, individuals on inflammatory diets exhibited a significantly higher odds ratio (OR) for experiencing more severe steatosis (OR: 4.11; 95% CI: 1.08–15.71) compared to those on anti-inflammatory diets. Furthermore, each unit increase in DII scores was linked to a 2.6-fold increase in the odds of more severe steatosis (OR: 2.61; 95% CI: 1.28–5.32) and a 0.006 increase in FIB-4 scores (β: 0.006; 95% CI: 0.003–0.011). In conclusion, modifying dietary intakes to lower DII scores may be a beneficial approach to improving clinical outcomes in pediatric MASLD, as anti-inflammatory diets are associated with reduced severity of hepatic steatosis and fibrosis.https://doi.org/10.1038/s41598-025-89690-xNon-alcoholic fatty liver diseaseFibrosisDietInflammationPediatrics |
| spellingShingle | Fateme Amiri Jalal Moludi Touraj Ahmadi Jouybari Mahmoud Ghasemi Maryam Sharifi Behzad Mahaki Davood Soleimani Relationship between dietary inflammatory index and metabolic dysfunction associated steatotic liver disease in children Scientific Reports Non-alcoholic fatty liver disease Fibrosis Diet Inflammation Pediatrics |
| title | Relationship between dietary inflammatory index and metabolic dysfunction associated steatotic liver disease in children |
| title_full | Relationship between dietary inflammatory index and metabolic dysfunction associated steatotic liver disease in children |
| title_fullStr | Relationship between dietary inflammatory index and metabolic dysfunction associated steatotic liver disease in children |
| title_full_unstemmed | Relationship between dietary inflammatory index and metabolic dysfunction associated steatotic liver disease in children |
| title_short | Relationship between dietary inflammatory index and metabolic dysfunction associated steatotic liver disease in children |
| title_sort | relationship between dietary inflammatory index and metabolic dysfunction associated steatotic liver disease in children |
| topic | Non-alcoholic fatty liver disease Fibrosis Diet Inflammation Pediatrics |
| url | https://doi.org/10.1038/s41598-025-89690-x |
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