Chronic stress in mice: how gut bacteria influence gene activity in key brain neurons

Chronic stress in mice: how gut bacteria influence gene activity in key brain neurons

Abstract Major depressive disorder (MDD) is a serious mental disorder. Increasing evidence suggests that changes of gut microbiota are involved in pathogenesis of depression, yet the underlying mechanisms remains unknown. Here, chronic unpredictable mild stress (CUMS) mice model was constructed to m...

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Main Authors: Wenxia Jiang, Yifan Li, Jie Yang, Xunmin Tan, Ruimin Tian, Guojing Ma, Jing Wu, Jianping Zhang, Yu Huang, Ping Liu, Minghao Yuan, Xiaodong Song, Leyao Luo, Xingyu Zhou, Hongzhou Zuo, Ma-Li Wong, Julio Licino, Peng Zheng
Format: Article
Language:English
Published: Nature Publishing Group 2025-08-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-025-03479-0
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