Failure to Identify the Left Arcuate Fasciculus at Diffusion Tractography Is a Specific Marker of Language Dysfunction in Pediatric Patients with Polymicrogyria
Background. Polymicrogyric cortex demonstrates interindividual variation with regard to both extent of dyslamination and functional capacity. Given the relationship between laminar structure and white matter fibers, we sought to define the relationship between polymicrogyria (PMG), intrahemispheric...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Behavioural Neurology |
| Online Access: | http://dx.doi.org/10.1155/2015/351391 |
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| author | Michael J. Paldino Kara Hedges Nadine Gaab Albert M. Galaburda P. Ellen Grant |
| author_facet | Michael J. Paldino Kara Hedges Nadine Gaab Albert M. Galaburda P. Ellen Grant |
| author_sort | Michael J. Paldino |
| collection | DOAJ |
| description | Background. Polymicrogyric cortex demonstrates interindividual variation with regard to both extent of dyslamination and functional capacity. Given the relationship between laminar structure and white matter fibers, we sought to define the relationship between polymicrogyria (PMG), intrahemispheric association pathways, and network function. Methods. Each arcuate fasciculus (AF) was categorized as present or absent. Language was characterized by a pediatric neurologist. The presence of dysplastic cortex in the expected anatomic locations of Broca’s (BA) and Wernicke’s areas (WA) was evaluated by two pediatric neuroradiologists blinded to DTI and language data. Results. 16 PMG patients and 16 age/gender-matched controls were included. All normative controls had an identifiable left AF. 6/7 PMG patients with dysplastic cortex within BA and/or WA had no left AF; PMG patients without involvement of these regions had a lower frequency of absence of the left AF (p<0.006). All patients without a left AF had some degree of language impairment. PMG patients without a left AF had a significantly greater frequency of language impairment compared to those PMG patients with a left AF (p<0.003). Conclusion. In patients with PMG (1) the presence of dysplastic cortex within WA and/or BA is associated with absence of the left AF and (2) absence of the left AF is associated with language impairment. |
| format | Article |
| id | doaj-art-98580bc5558a4ec99e486f9913cc03bd |
| institution | Kabale University |
| issn | 0953-4180 1875-8584 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Behavioural Neurology |
| spelling | doaj-art-98580bc5558a4ec99e486f9913cc03bd2025-08-20T03:37:22ZengWileyBehavioural Neurology0953-41801875-85842015-01-01201510.1155/2015/351391351391Failure to Identify the Left Arcuate Fasciculus at Diffusion Tractography Is a Specific Marker of Language Dysfunction in Pediatric Patients with PolymicrogyriaMichael J. Paldino0Kara Hedges1Nadine Gaab2Albert M. Galaburda3P. Ellen Grant4Department of Radiology, Boston Children’s Hospital and Harvard Medical School, Boston, MA 02115, USADepartment of Radiology, Boston Children’s Hospital and Harvard Medical School, Boston, MA 02115, USADevelopmental Medicine Center, Boston Children’s Hospital and Harvard Medical School, Boston, MA 02115, USADepartment of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USADepartments of Radiology and Newborn Medicine, Boston Children’s Hospital and Harvard Medical School, Boston, MA 02115, USABackground. Polymicrogyric cortex demonstrates interindividual variation with regard to both extent of dyslamination and functional capacity. Given the relationship between laminar structure and white matter fibers, we sought to define the relationship between polymicrogyria (PMG), intrahemispheric association pathways, and network function. Methods. Each arcuate fasciculus (AF) was categorized as present or absent. Language was characterized by a pediatric neurologist. The presence of dysplastic cortex in the expected anatomic locations of Broca’s (BA) and Wernicke’s areas (WA) was evaluated by two pediatric neuroradiologists blinded to DTI and language data. Results. 16 PMG patients and 16 age/gender-matched controls were included. All normative controls had an identifiable left AF. 6/7 PMG patients with dysplastic cortex within BA and/or WA had no left AF; PMG patients without involvement of these regions had a lower frequency of absence of the left AF (p<0.006). All patients without a left AF had some degree of language impairment. PMG patients without a left AF had a significantly greater frequency of language impairment compared to those PMG patients with a left AF (p<0.003). Conclusion. In patients with PMG (1) the presence of dysplastic cortex within WA and/or BA is associated with absence of the left AF and (2) absence of the left AF is associated with language impairment.http://dx.doi.org/10.1155/2015/351391 |
| spellingShingle | Michael J. Paldino Kara Hedges Nadine Gaab Albert M. Galaburda P. Ellen Grant Failure to Identify the Left Arcuate Fasciculus at Diffusion Tractography Is a Specific Marker of Language Dysfunction in Pediatric Patients with Polymicrogyria Behavioural Neurology |
| title | Failure to Identify the Left Arcuate Fasciculus at Diffusion Tractography Is a Specific Marker of Language Dysfunction in Pediatric Patients with Polymicrogyria |
| title_full | Failure to Identify the Left Arcuate Fasciculus at Diffusion Tractography Is a Specific Marker of Language Dysfunction in Pediatric Patients with Polymicrogyria |
| title_fullStr | Failure to Identify the Left Arcuate Fasciculus at Diffusion Tractography Is a Specific Marker of Language Dysfunction in Pediatric Patients with Polymicrogyria |
| title_full_unstemmed | Failure to Identify the Left Arcuate Fasciculus at Diffusion Tractography Is a Specific Marker of Language Dysfunction in Pediatric Patients with Polymicrogyria |
| title_short | Failure to Identify the Left Arcuate Fasciculus at Diffusion Tractography Is a Specific Marker of Language Dysfunction in Pediatric Patients with Polymicrogyria |
| title_sort | failure to identify the left arcuate fasciculus at diffusion tractography is a specific marker of language dysfunction in pediatric patients with polymicrogyria |
| url | http://dx.doi.org/10.1155/2015/351391 |
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