Heterogeneity in NK Cell Subpopulations May Be Involved in Kidney Cancer Metastasis
Although substantial progress has been made in the immunotherapy of kidney cancer, its efficacy varies from patient to patient, with many responding suboptimally or even developing metastases. Thus, research on the tumour immune microenvironment and immune cell heterogeneity is essential for kidney...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-01-01
|
| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2022/6378567 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832563106761408512 |
|---|---|
| author | Zhengfang Liang Fengwei Nong Jingjie Zhao Dalong Wei Qianli Tang Jian Song Lingzhang Meng |
| author_facet | Zhengfang Liang Fengwei Nong Jingjie Zhao Dalong Wei Qianli Tang Jian Song Lingzhang Meng |
| author_sort | Zhengfang Liang |
| collection | DOAJ |
| description | Although substantial progress has been made in the immunotherapy of kidney cancer, its efficacy varies from patient to patient, with many responding suboptimally or even developing metastases. Thus, research on the tumour immune microenvironment and immune cell heterogeneity is essential for kidney cancer treatment. In this study, natural killer (NK) cell populations were isolated using signature genes from the single-cell sequencing data of clear cell renal cell carcinoma (ccRCC) and normal kidney tissues and divided into three subpopulations according to the differences in gene expression profiles: NK(GZMH), NK(EGR1), and NK(CAPG). Gene set enrichment analysis revealed that NK(EGR1) and NK(CAPG) were closely related to tumour metastasis, as shown by kidney cancer metastasis to Hodgkin lymphoma, T-cell leukaemia, and Ki-1+ anaplastic large cell lymphoma. Thus, these two NK cell subpopulations are promising targets for inhibiting metastasis in ccRCC. Our findings revealed heterogeneity in the infiltrating NK cells of kidney cancer, which can serve as a reference for the mechanisms underlying metastasis in kidney cancer. |
| format | Article |
| id | doaj-art-9855283eeb0d41ba81c438600edfb390 |
| institution | Kabale University |
| issn | 2314-7156 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-9855283eeb0d41ba81c438600edfb3902025-02-03T01:21:04ZengWileyJournal of Immunology Research2314-71562022-01-01202210.1155/2022/6378567Heterogeneity in NK Cell Subpopulations May Be Involved in Kidney Cancer MetastasisZhengfang Liang0Fengwei Nong1Jingjie Zhao2Dalong Wei3Qianli Tang4Jian Song5Lingzhang Meng6Jinan UniversityCenter for Systemic Inflammation Research (CSIR)Life Science and Clinical Research CenterBurn Plastic & Trauma Surgery DepartmentJinan UniversityCenter for Systemic Inflammation Research (CSIR)Center for Systemic Inflammation Research (CSIR)Although substantial progress has been made in the immunotherapy of kidney cancer, its efficacy varies from patient to patient, with many responding suboptimally or even developing metastases. Thus, research on the tumour immune microenvironment and immune cell heterogeneity is essential for kidney cancer treatment. In this study, natural killer (NK) cell populations were isolated using signature genes from the single-cell sequencing data of clear cell renal cell carcinoma (ccRCC) and normal kidney tissues and divided into three subpopulations according to the differences in gene expression profiles: NK(GZMH), NK(EGR1), and NK(CAPG). Gene set enrichment analysis revealed that NK(EGR1) and NK(CAPG) were closely related to tumour metastasis, as shown by kidney cancer metastasis to Hodgkin lymphoma, T-cell leukaemia, and Ki-1+ anaplastic large cell lymphoma. Thus, these two NK cell subpopulations are promising targets for inhibiting metastasis in ccRCC. Our findings revealed heterogeneity in the infiltrating NK cells of kidney cancer, which can serve as a reference for the mechanisms underlying metastasis in kidney cancer.http://dx.doi.org/10.1155/2022/6378567 |
| spellingShingle | Zhengfang Liang Fengwei Nong Jingjie Zhao Dalong Wei Qianli Tang Jian Song Lingzhang Meng Heterogeneity in NK Cell Subpopulations May Be Involved in Kidney Cancer Metastasis Journal of Immunology Research |
| title | Heterogeneity in NK Cell Subpopulations May Be Involved in Kidney Cancer Metastasis |
| title_full | Heterogeneity in NK Cell Subpopulations May Be Involved in Kidney Cancer Metastasis |
| title_fullStr | Heterogeneity in NK Cell Subpopulations May Be Involved in Kidney Cancer Metastasis |
| title_full_unstemmed | Heterogeneity in NK Cell Subpopulations May Be Involved in Kidney Cancer Metastasis |
| title_short | Heterogeneity in NK Cell Subpopulations May Be Involved in Kidney Cancer Metastasis |
| title_sort | heterogeneity in nk cell subpopulations may be involved in kidney cancer metastasis |
| url | http://dx.doi.org/10.1155/2022/6378567 |
| work_keys_str_mv | AT zhengfangliang heterogeneityinnkcellsubpopulationsmaybeinvolvedinkidneycancermetastasis AT fengweinong heterogeneityinnkcellsubpopulationsmaybeinvolvedinkidneycancermetastasis AT jingjiezhao heterogeneityinnkcellsubpopulationsmaybeinvolvedinkidneycancermetastasis AT dalongwei heterogeneityinnkcellsubpopulationsmaybeinvolvedinkidneycancermetastasis AT qianlitang heterogeneityinnkcellsubpopulationsmaybeinvolvedinkidneycancermetastasis AT jiansong heterogeneityinnkcellsubpopulationsmaybeinvolvedinkidneycancermetastasis AT lingzhangmeng heterogeneityinnkcellsubpopulationsmaybeinvolvedinkidneycancermetastasis |