Frequency-risk and duration-risk relationships between aspirin use and gastric cancer: a systematic review and meta-analysis.
<h4>Background</h4>Although previous meta-analyses have suggested an association between aspirin use and risk of gastric cancer, current evidence is inconsistent. Additionally, it remains unclear whether there are frequency-risk and duration-risk relationships and if a threshold of effec...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0071522 |
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| author | Xiaohua Ye Jinjian Fu Yi Yang Yanhui Gao Li Liu Sidong Chen |
| author_facet | Xiaohua Ye Jinjian Fu Yi Yang Yanhui Gao Li Liu Sidong Chen |
| author_sort | Xiaohua Ye |
| collection | DOAJ |
| description | <h4>Background</h4>Although previous meta-analyses have suggested an association between aspirin use and risk of gastric cancer, current evidence is inconsistent. Additionally, it remains unclear whether there are frequency-risk and duration-risk relationships and if a threshold of effect exists.<h4>Methods</h4>We identified studies by searching MEDLINE and PUBMED databases and reviewing relevant articles. We derived the summary risk estimates using fixed-effects or random-effects model based on homogeneity analysis. The dose-response meta-analysis was performed by linear trend regression and restricted cubic spline regression. Potential heterogeneity was tested using the Q statistic and quantified with the I (2) statistic. Subgroup analyses and Galbraith plots were used to explore the potential sources of heterogeneity. Publication bias was evaluated with funnel plots and quantified by the Begg's and Egger's test.<h4>Results</h4>Fifteen studies were included in this meta-analysis. There was an overall 29% reduced risk of gastric cancer corresponding to aspirin use (RR = 0.71, 95% CI 0.60-0.82). We found there are nonlinear frequency-risk and linear duration-risk relations between aspirin use and gastric cancer. A monotonically decreasing relation was observed only for low-frequency (≤4.5 times/week) aspirin intake (10% decreased risk for once/week, 19% for twice/week and 29% for 4.5 times/week), and the frequency threshold of aspirin use is 4.5 times per week. Regarding those with duration of aspirin use, there was a tendency towards stronger risk reduction of gastric cancer for longer aspirin use (10% decreased risk for 4 years, 19% for 8 years and 28% for 12 years), and no duration threshold was observed.<h4>Conclusion</h4>Our findings suggest that long-term (≥4 years) and low-frequency (1-4.5 times per week) aspirin use is associated with a statistically significant, dose-dependent reduction in the risk of gastric cancer. |
| format | Article |
| id | doaj-art-9852fee7b70f4200b8f4788ef5ad804d |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-9852fee7b70f4200b8f4788ef5ad804d2025-08-20T03:29:04ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0187e7152210.1371/journal.pone.0071522Frequency-risk and duration-risk relationships between aspirin use and gastric cancer: a systematic review and meta-analysis.Xiaohua YeJinjian FuYi YangYanhui GaoLi LiuSidong Chen<h4>Background</h4>Although previous meta-analyses have suggested an association between aspirin use and risk of gastric cancer, current evidence is inconsistent. Additionally, it remains unclear whether there are frequency-risk and duration-risk relationships and if a threshold of effect exists.<h4>Methods</h4>We identified studies by searching MEDLINE and PUBMED databases and reviewing relevant articles. We derived the summary risk estimates using fixed-effects or random-effects model based on homogeneity analysis. The dose-response meta-analysis was performed by linear trend regression and restricted cubic spline regression. Potential heterogeneity was tested using the Q statistic and quantified with the I (2) statistic. Subgroup analyses and Galbraith plots were used to explore the potential sources of heterogeneity. Publication bias was evaluated with funnel plots and quantified by the Begg's and Egger's test.<h4>Results</h4>Fifteen studies were included in this meta-analysis. There was an overall 29% reduced risk of gastric cancer corresponding to aspirin use (RR = 0.71, 95% CI 0.60-0.82). We found there are nonlinear frequency-risk and linear duration-risk relations between aspirin use and gastric cancer. A monotonically decreasing relation was observed only for low-frequency (≤4.5 times/week) aspirin intake (10% decreased risk for once/week, 19% for twice/week and 29% for 4.5 times/week), and the frequency threshold of aspirin use is 4.5 times per week. Regarding those with duration of aspirin use, there was a tendency towards stronger risk reduction of gastric cancer for longer aspirin use (10% decreased risk for 4 years, 19% for 8 years and 28% for 12 years), and no duration threshold was observed.<h4>Conclusion</h4>Our findings suggest that long-term (≥4 years) and low-frequency (1-4.5 times per week) aspirin use is associated with a statistically significant, dose-dependent reduction in the risk of gastric cancer.https://doi.org/10.1371/journal.pone.0071522 |
| spellingShingle | Xiaohua Ye Jinjian Fu Yi Yang Yanhui Gao Li Liu Sidong Chen Frequency-risk and duration-risk relationships between aspirin use and gastric cancer: a systematic review and meta-analysis. PLoS ONE |
| title | Frequency-risk and duration-risk relationships between aspirin use and gastric cancer: a systematic review and meta-analysis. |
| title_full | Frequency-risk and duration-risk relationships between aspirin use and gastric cancer: a systematic review and meta-analysis. |
| title_fullStr | Frequency-risk and duration-risk relationships between aspirin use and gastric cancer: a systematic review and meta-analysis. |
| title_full_unstemmed | Frequency-risk and duration-risk relationships between aspirin use and gastric cancer: a systematic review and meta-analysis. |
| title_short | Frequency-risk and duration-risk relationships between aspirin use and gastric cancer: a systematic review and meta-analysis. |
| title_sort | frequency risk and duration risk relationships between aspirin use and gastric cancer a systematic review and meta analysis |
| url | https://doi.org/10.1371/journal.pone.0071522 |
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