Progress in immunotherapy for brain metastatic melanoma
Melanoma is highly aggressive, with brain metastasis being a significant contributor to poor outcomes. Immunotherapy has emerged as a crucial treatment modality for melanoma, particularly for addressing brain metastases. This review explores recent developments in immunotherapy for patients with mel...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2024.1485532/full |
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| _version_ | 1832583798200467456 |
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| author | Shicheng Zheng Zhongqiao Lin Ruibo Zhang Zihang Cheng Kaixin Li Chenkai Gu Yu Chen Yu Chen Jing Lin Jing Lin |
| author_facet | Shicheng Zheng Zhongqiao Lin Ruibo Zhang Zihang Cheng Kaixin Li Chenkai Gu Yu Chen Yu Chen Jing Lin Jing Lin |
| author_sort | Shicheng Zheng |
| collection | DOAJ |
| description | Melanoma is highly aggressive, with brain metastasis being a significant contributor to poor outcomes. Immunotherapy has emerged as a crucial treatment modality for melanoma, particularly for addressing brain metastases. This review explores recent developments in immunotherapy for patients with melanoma brain metastasis, with such treatments encompassing immune checkpoint inhibitors and various immunotherapy combination approaches, such as dual immunotherapy, immunotherapy combined with chemotherapy, immunotherapy combined with targeted drugs, and immunotherapy combined with radiotherapy. This article also discusses existing treatment obstacles and potential future avenues for research and clinical practice. |
| format | Article |
| id | doaj-art-984c88337e2747eda767158a6aa0081d |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-984c88337e2747eda767158a6aa0081d2025-01-28T05:10:30ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-01-011410.3389/fonc.2024.14855321485532Progress in immunotherapy for brain metastatic melanomaShicheng Zheng0Zhongqiao Lin1Ruibo Zhang2Zihang Cheng3Kaixin Li4Chenkai Gu5Yu Chen6Yu Chen7Jing Lin8Jing Lin9School of Basic Medicine, Fujian Medical University, Fuzhou, Fujian, ChinaPhase I Clinical Trial Ward, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, Fujian, ChinaSchool of Basic Medicine, Fujian Medical University, Fuzhou, Fujian, ChinaSchool of Basic Medicine, Fujian Medical University, Fuzhou, Fujian, ChinaSchool of Basic Medicine, Fujian Medical University, Fuzhou, Fujian, ChinaSchool of Basic Medicine, Fujian Medical University, Fuzhou, Fujian, ChinaDepartment of Medical Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, Fujian, ChinaCancer Bio-Immunotherapy Center, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, Fujian, ChinaDepartment of Medical Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, Fujian, ChinaCancer Bio-Immunotherapy Center, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, Fujian, ChinaMelanoma is highly aggressive, with brain metastasis being a significant contributor to poor outcomes. Immunotherapy has emerged as a crucial treatment modality for melanoma, particularly for addressing brain metastases. This review explores recent developments in immunotherapy for patients with melanoma brain metastasis, with such treatments encompassing immune checkpoint inhibitors and various immunotherapy combination approaches, such as dual immunotherapy, immunotherapy combined with chemotherapy, immunotherapy combined with targeted drugs, and immunotherapy combined with radiotherapy. This article also discusses existing treatment obstacles and potential future avenues for research and clinical practice.https://www.frontiersin.org/articles/10.3389/fonc.2024.1485532/fullmelanomabrain metastasisimmunotherapyimmune checkpoint inhibitorscombination therapy |
| spellingShingle | Shicheng Zheng Zhongqiao Lin Ruibo Zhang Zihang Cheng Kaixin Li Chenkai Gu Yu Chen Yu Chen Jing Lin Jing Lin Progress in immunotherapy for brain metastatic melanoma Frontiers in Oncology melanoma brain metastasis immunotherapy immune checkpoint inhibitors combination therapy |
| title | Progress in immunotherapy for brain metastatic melanoma |
| title_full | Progress in immunotherapy for brain metastatic melanoma |
| title_fullStr | Progress in immunotherapy for brain metastatic melanoma |
| title_full_unstemmed | Progress in immunotherapy for brain metastatic melanoma |
| title_short | Progress in immunotherapy for brain metastatic melanoma |
| title_sort | progress in immunotherapy for brain metastatic melanoma |
| topic | melanoma brain metastasis immunotherapy immune checkpoint inhibitors combination therapy |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2024.1485532/full |
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