Cohort profile: Outcome Monitoring After Cardiac Surgery (OMACS) – a prospective UK cohort study of cardiac surgery patients at the Bristol Heart Institute
Purpose The Outcome Monitoring After Cardiac Surgery (OMACS) cohort study was set-up with the aim of establishing a rich source of biological samples and health status data from patients who undergo cardiac surgery. The objectives were to use these data to inform the design of new clinical studies a...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMJ Publishing Group
2025-02-01
|
| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/15/2/e091518.full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832087788471713792 |
|---|---|
| author | Chris A Rogers Gianni Angelini Lucy Culliford Rachel Brierley Barnaby Reeves Katherine Joyce Terrie Walker-Smith Rachel Maishman Emma Hopkins Penny Lambert Helena Smartt |
| author_facet | Chris A Rogers Gianni Angelini Lucy Culliford Rachel Brierley Barnaby Reeves Katherine Joyce Terrie Walker-Smith Rachel Maishman Emma Hopkins Penny Lambert Helena Smartt |
| author_sort | Chris A Rogers |
| collection | DOAJ |
| description | Purpose The Outcome Monitoring After Cardiac Surgery (OMACS) cohort study was set-up with the aim of establishing a rich source of biological samples and health status data from patients who undergo cardiac surgery. The objectives were to use these data to inform the design of new clinical studies and to provide samples and data to answer research questions.Participants Recruitment began on 23 May 2016 and ended 31 May 2022. Adult patients undergoing cardiac surgery at University Hospitals Bristol and Weston NHS Foundation Trust were screened and approached for consent. Participants could optionally consent to provide biological samples (urine, blood and waste tissue) in addition to data. A total of 4068 patients consented to participate in the study with 2027 consenting to donate samples. Participants were sent quality-of-life follow-up questionnaires at 3 and 12 months after surgery. The clinical data were collected from hospital records/databases.Findings to date The OMACS population appears to be representative of the wider cardiac surgery population with similar preoperative demography to those reported on the UK surgery population. To date, eight studies have been carried out by research teams using data from a total of 1165 OMACS participants. Two Studies Within A Trial have been performed by the OMACS study team. The format of the study patient information leaflet was not significantly associated with an increased recruitment rate, and an alternative theory-informed cover letter included with the 12-month follow-up questionnaires was not associated with an increase in questionnaire completion. Additional exploratory research carried out within the OMACS study has been presented at international conferences.Future plans The OMACS study is now closed. The cohort’s data and samples will be available to share with researchers, providing an opportunity to answer a variety of research questions (eg, evaluating predictors of adverse outcomes after cardiac surgery such as biomarkers, surgical methods and pre-existing conditions). The data and samples will be available for sharing in a linked anonymised format.Trial registration number ISRCTN90204321 (date assigned: 21 January 2015). |
| format | Article |
| id | doaj-art-98482316033046438102989ecf5a4d42 |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-98482316033046438102989ecf5a4d422025-02-06T04:25:09ZengBMJ Publishing GroupBMJ Open2044-60552025-02-0115210.1136/bmjopen-2024-091518Cohort profile: Outcome Monitoring After Cardiac Surgery (OMACS) – a prospective UK cohort study of cardiac surgery patients at the Bristol Heart InstituteChris A Rogers0Gianni Angelini1Lucy Culliford2Rachel Brierley3Barnaby Reeves4Katherine Joyce5Terrie Walker-Smith6Rachel Maishman7Emma Hopkins8Penny Lambert9Helena Smartt10University of Bristol, Bristol, UKBristol Heart Institute, Bristol, UKBristol Trials Centre, University of Bristol, Bristol, UKBristol Trials Centre, University of Bristol, Bristol, UKUniversity of Bristol, Bristol, UKBristol Trials Centre, University of Bristol, Bristol, UKBristol Trials Centre, University of Bristol, Bristol, UKBristol Trials Centre, University of Bristol, Bristol, UKBristol Heart Institute, Bristol, UKBristol Heart Institute, Bristol, UKBristol Trials Centre, University of Bristol, Bristol, UKPurpose The Outcome Monitoring After Cardiac Surgery (OMACS) cohort study was set-up with the aim of establishing a rich source of biological samples and health status data from patients who undergo cardiac surgery. The objectives were to use these data to inform the design of new clinical studies and to provide samples and data to answer research questions.Participants Recruitment began on 23 May 2016 and ended 31 May 2022. Adult patients undergoing cardiac surgery at University Hospitals Bristol and Weston NHS Foundation Trust were screened and approached for consent. Participants could optionally consent to provide biological samples (urine, blood and waste tissue) in addition to data. A total of 4068 patients consented to participate in the study with 2027 consenting to donate samples. Participants were sent quality-of-life follow-up questionnaires at 3 and 12 months after surgery. The clinical data were collected from hospital records/databases.Findings to date The OMACS population appears to be representative of the wider cardiac surgery population with similar preoperative demography to those reported on the UK surgery population. To date, eight studies have been carried out by research teams using data from a total of 1165 OMACS participants. Two Studies Within A Trial have been performed by the OMACS study team. The format of the study patient information leaflet was not significantly associated with an increased recruitment rate, and an alternative theory-informed cover letter included with the 12-month follow-up questionnaires was not associated with an increase in questionnaire completion. Additional exploratory research carried out within the OMACS study has been presented at international conferences.Future plans The OMACS study is now closed. The cohort’s data and samples will be available to share with researchers, providing an opportunity to answer a variety of research questions (eg, evaluating predictors of adverse outcomes after cardiac surgery such as biomarkers, surgical methods and pre-existing conditions). The data and samples will be available for sharing in a linked anonymised format.Trial registration number ISRCTN90204321 (date assigned: 21 January 2015).https://bmjopen.bmj.com/content/15/2/e091518.full |
| spellingShingle | Chris A Rogers Gianni Angelini Lucy Culliford Rachel Brierley Barnaby Reeves Katherine Joyce Terrie Walker-Smith Rachel Maishman Emma Hopkins Penny Lambert Helena Smartt Cohort profile: Outcome Monitoring After Cardiac Surgery (OMACS) – a prospective UK cohort study of cardiac surgery patients at the Bristol Heart Institute BMJ Open |
| title | Cohort profile: Outcome Monitoring After Cardiac Surgery (OMACS) – a prospective UK cohort study of cardiac surgery patients at the Bristol Heart Institute |
| title_full | Cohort profile: Outcome Monitoring After Cardiac Surgery (OMACS) – a prospective UK cohort study of cardiac surgery patients at the Bristol Heart Institute |
| title_fullStr | Cohort profile: Outcome Monitoring After Cardiac Surgery (OMACS) – a prospective UK cohort study of cardiac surgery patients at the Bristol Heart Institute |
| title_full_unstemmed | Cohort profile: Outcome Monitoring After Cardiac Surgery (OMACS) – a prospective UK cohort study of cardiac surgery patients at the Bristol Heart Institute |
| title_short | Cohort profile: Outcome Monitoring After Cardiac Surgery (OMACS) – a prospective UK cohort study of cardiac surgery patients at the Bristol Heart Institute |
| title_sort | cohort profile outcome monitoring after cardiac surgery omacs a prospective uk cohort study of cardiac surgery patients at the bristol heart institute |
| url | https://bmjopen.bmj.com/content/15/2/e091518.full |
| work_keys_str_mv | AT chrisarogers cohortprofileoutcomemonitoringaftercardiacsurgeryomacsaprospectiveukcohortstudyofcardiacsurgerypatientsatthebristolheartinstitute AT gianniangelini cohortprofileoutcomemonitoringaftercardiacsurgeryomacsaprospectiveukcohortstudyofcardiacsurgerypatientsatthebristolheartinstitute AT lucyculliford cohortprofileoutcomemonitoringaftercardiacsurgeryomacsaprospectiveukcohortstudyofcardiacsurgerypatientsatthebristolheartinstitute AT rachelbrierley cohortprofileoutcomemonitoringaftercardiacsurgeryomacsaprospectiveukcohortstudyofcardiacsurgerypatientsatthebristolheartinstitute AT barnabyreeves cohortprofileoutcomemonitoringaftercardiacsurgeryomacsaprospectiveukcohortstudyofcardiacsurgerypatientsatthebristolheartinstitute AT katherinejoyce cohortprofileoutcomemonitoringaftercardiacsurgeryomacsaprospectiveukcohortstudyofcardiacsurgerypatientsatthebristolheartinstitute AT terriewalkersmith cohortprofileoutcomemonitoringaftercardiacsurgeryomacsaprospectiveukcohortstudyofcardiacsurgerypatientsatthebristolheartinstitute AT rachelmaishman cohortprofileoutcomemonitoringaftercardiacsurgeryomacsaprospectiveukcohortstudyofcardiacsurgerypatientsatthebristolheartinstitute AT emmahopkins cohortprofileoutcomemonitoringaftercardiacsurgeryomacsaprospectiveukcohortstudyofcardiacsurgerypatientsatthebristolheartinstitute AT pennylambert cohortprofileoutcomemonitoringaftercardiacsurgeryomacsaprospectiveukcohortstudyofcardiacsurgerypatientsatthebristolheartinstitute AT helenasmartt cohortprofileoutcomemonitoringaftercardiacsurgeryomacsaprospectiveukcohortstudyofcardiacsurgerypatientsatthebristolheartinstitute |