Gasdermin D deletion prevents liver injury and exacerbates extrahepatic damage in a murine model of alcohol-induced ACLF

Gasdermin D deletion prevents liver injury and exacerbates extrahepatic damage in a murine model of alcohol-induced ACLF

Background Gasdermin D (GSDM-D), a key executor of pyroptosis, is increased in various liver diseases and contributes to disease progression. Alcohol induces inflammasome activation and cell death, which are both linked to GSDM-D activation. However, its role in alcohol-induced acute-on-chronic live...

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Bibliographic Details
Main Authors: Yuan Zhuang, Gyongyi Szabo, Martí Ortega-Ribera, Veronika Brezani, Radhika S Joshi, Zsuzsanna Zsengeller, Prashanth Thevkar Nagesh, Aditi Datta
Format: Article
Language:English
Published: BMJ Publishing Group 2025-03-01
Series:eGastroenterology
Online Access:https://egastroenterology.bmj.com/content/3/1/e100151.full
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