Preparation of a New Active Component 1,10-B<sub>10</sub>H<sub>8</sub>(S(C<sub>18</sub>H<sub>37</sub>)<sub>2</sub>)<sub>2</sub> for Potentiometric Membranes for the Determination of Terbinafine Hydrochloride
This paper presents a methodology for the preparation of a new active component for ion-selective membranes, based on a di-substituted sulfonium derivative of the <i>closo</i>-decaborate anion at the apical vertices with the octadecylalkyl substituents 1,10-B<sub>10</sub>H<...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-01-01
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| Series: | Inorganics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2304-6740/13/2/35 |
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| Summary: | This paper presents a methodology for the preparation of a new active component for ion-selective membranes, based on a di-substituted sulfonium derivative of the <i>closo</i>-decaborate anion at the apical vertices with the octadecylalkyl substituents 1,10-B<sub>10</sub>H<sub>8</sub>(S(C<sub>18</sub>H<sub>37</sub>)<sub>2</sub>)<sub>2</sub>. This approach is characterized by physicochemical methods of analysis (11B, 1H, 13C NMR spectroscopy, IR spectroscopy and elemental analysis). The compound obtained is used as an active component of a PVC membrane selective to terbinafine hydrochloride. The sensor developed is highly selective to the drug to be detected, has a linearity range of 4.0 × 10<sup>−8</sup>–1.0 × 10<sup>−2</sup> and a detection limit of 1.0 × 10<sup>−8</sup>, and can detect terbinafine hydrochloride in the pH range of 3 to 6. |
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| ISSN: | 2304-6740 |