THE ROLE OF MATERNAL AND PATERNAL HLA-DRB1* IN CONGENITAL HEART DISEASE OF THEIR CHILDREN
Aim. To study the associations of the maternal and paternal alleles and genotypes within the HLA-DRB1* gene with the risk of congenital heart diseases (CHD) in their children. Materials and Methods. Having performed the genotyping, we compared the allele frequencies and genotypes within t...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
Kemerovo State Medical University
2017-03-01
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| Series: | Фундаментальная и клиническая медицина |
| Online Access: | https://fcm.kemsmu.ru/jour/article/view/27 |
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| Summary: | Aim. To study the associations of the maternal and paternal alleles and genotypes within the HLA-DRB1* gene with the risk of congenital heart diseases (CHD) in their children. Materials and Methods. Having performed the genotyping, we compared the allele frequencies and genotypes within the HLA-DRB1* in females (experimental group 1, n = 97) and males (experimental group 2, n = 59) who have children with CHD and in females (control group, n = 54) and males (control group 2, n = 98) with healthy children. Results. HLA-DRB1*03 (OR = 5.56) and HLA-DRB1*11 (OR = 4.31) alleles in females along with HLA-DRB1*07 (OR=2.72) allele and HLA-DRB1*01, 04 (OR=15.81) genotype in males were associated with a high risk of CHD. On the contrary, allele HLA-DRB1*12 (OR = 0.28) and HLA- DRB1*01, 12 genotype (OR = 0.06) in females correlated with a lower CHD risk. Conclusions. Inherited variation within the HLA-DRB1* gene is associated with a high risk of CHD in the next generation. |
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| ISSN: | 2500-0764 2542-0941 |