Modern concepts on pathogenetic mechanisms of liver fibrosis
This review summarizes current data on the pathogenetic mechanisms of fibrosis in chronic liver diseases. Controlled inflammation and transdifferentiation of hepatic stellate cells into myofibroblasts is a key element of fibrogenesis, however, further study of the role of each of the macrophage popu...
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| Format: | Article |
| Language: | Russian |
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Journal Infectology
2023-04-01
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| Series: | Журнал инфектологии |
| Subjects: | |
| Online Access: | https://journal.niidi.ru/jofin/article/view/1466 |
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| author | N. A. Efremova V. A. Greshnyakova L. G. Goryacheva |
| author_facet | N. A. Efremova V. A. Greshnyakova L. G. Goryacheva |
| author_sort | N. A. Efremova |
| collection | DOAJ |
| description | This review summarizes current data on the pathogenetic mechanisms of fibrosis in chronic liver diseases. Controlled inflammation and transdifferentiation of hepatic stellate cells into myofibroblasts is a key element of fibrogenesis, however, further study of the role of each of the macrophage populations is required. The initiation and progression of liver fibrosis is promoted by a complex interaction of different types of liver cells, mediated by cytokines, growth factors, miRNAs. Repeated cycles of apoptosis and regeneration of hepatocytes contribute to the pathogenesis of fibrosis. Modern experimental work has proven the role of mesenchymal stem cells in liver regeneration by inhibiting the expression of the proapoptotic BAX gene. The involution of liver fibrosis is associated with monocytes of the prorestorative phenotype LY6Clow. On in vivo models, regression of fibrosis and utilization of the extracellular matrix depot by inhibition of miRNA-221-3p of hepatocytes have been proven. |
| format | Article |
| id | doaj-art-9839170f8f8e4c19b3abf2cbe18259df |
| institution | Kabale University |
| issn | 2072-6732 |
| language | Russian |
| publishDate | 2023-04-01 |
| publisher | Journal Infectology |
| record_format | Article |
| series | Журнал инфектологии |
| spelling | doaj-art-9839170f8f8e4c19b3abf2cbe18259df2025-08-20T04:00:17ZrusJournal InfectologyЖурнал инфектологии2072-67322023-04-01151162410.22625/2072-6732-2023-15-1-16-241049Modern concepts on pathogenetic mechanisms of liver fibrosisN. A. Efremova0V. A. Greshnyakova1L. G. Goryacheva2Pediatric Research and Clinical Center for Infectious DiseasesPediatric Research and Clinical Center for Infectious DiseasesPediatric Research and Clinical Center for Infectious DiseasesThis review summarizes current data on the pathogenetic mechanisms of fibrosis in chronic liver diseases. Controlled inflammation and transdifferentiation of hepatic stellate cells into myofibroblasts is a key element of fibrogenesis, however, further study of the role of each of the macrophage populations is required. The initiation and progression of liver fibrosis is promoted by a complex interaction of different types of liver cells, mediated by cytokines, growth factors, miRNAs. Repeated cycles of apoptosis and regeneration of hepatocytes contribute to the pathogenesis of fibrosis. Modern experimental work has proven the role of mesenchymal stem cells in liver regeneration by inhibiting the expression of the proapoptotic BAX gene. The involution of liver fibrosis is associated with monocytes of the prorestorative phenotype LY6Clow. On in vivo models, regression of fibrosis and utilization of the extracellular matrix depot by inhibition of miRNA-221-3p of hepatocytes have been proven.https://journal.niidi.ru/jofin/article/view/1466liver fibrosispathogenesis of liver fibrosisstellate cellsmyofibroblastsmesenchymal stem cellscytokinesmirnaregeneration of liver fibrosisregression of liver fibrosis |
| spellingShingle | N. A. Efremova V. A. Greshnyakova L. G. Goryacheva Modern concepts on pathogenetic mechanisms of liver fibrosis Журнал инфектологии liver fibrosis pathogenesis of liver fibrosis stellate cells myofibroblasts mesenchymal stem cells cytokines mirna regeneration of liver fibrosis regression of liver fibrosis |
| title | Modern concepts on pathogenetic mechanisms of liver fibrosis |
| title_full | Modern concepts on pathogenetic mechanisms of liver fibrosis |
| title_fullStr | Modern concepts on pathogenetic mechanisms of liver fibrosis |
| title_full_unstemmed | Modern concepts on pathogenetic mechanisms of liver fibrosis |
| title_short | Modern concepts on pathogenetic mechanisms of liver fibrosis |
| title_sort | modern concepts on pathogenetic mechanisms of liver fibrosis |
| topic | liver fibrosis pathogenesis of liver fibrosis stellate cells myofibroblasts mesenchymal stem cells cytokines mirna regeneration of liver fibrosis regression of liver fibrosis |
| url | https://journal.niidi.ru/jofin/article/view/1466 |
| work_keys_str_mv | AT naefremova modernconceptsonpathogeneticmechanismsofliverfibrosis AT vagreshnyakova modernconceptsonpathogeneticmechanismsofliverfibrosis AT lggoryacheva modernconceptsonpathogeneticmechanismsofliverfibrosis |