Oncogenic Alternative Splicing Switches: Role in Cancer Progression and Prospects for Therapy
Alterations in the abundance or activities of alternative splicing regulators generate alternatively spliced variants that contribute to multiple aspects of tumor establishment, progression and resistance to therapeutic treatments. Notably, many cancer-associated genes are regulated through alternat...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
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| Series: | International Journal of Cell Biology |
| Online Access: | http://dx.doi.org/10.1155/2013/962038 |
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| _version_ | 1850208942683062272 |
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| author | Serena Bonomi Stefania Gallo Morena Catillo Daniela Pignataro Giuseppe Biamonti Claudia Ghigna |
| author_facet | Serena Bonomi Stefania Gallo Morena Catillo Daniela Pignataro Giuseppe Biamonti Claudia Ghigna |
| author_sort | Serena Bonomi |
| collection | DOAJ |
| description | Alterations in the abundance or activities of alternative splicing regulators generate alternatively spliced variants that contribute to multiple aspects of tumor establishment, progression and resistance to therapeutic treatments. Notably, many cancer-associated genes are regulated through alternative splicing suggesting a significant role of this post-transcriptional regulatory mechanism in the production of oncogenes and tumor suppressors. Thus, the study of alternative splicing in cancer might provide a better understanding of the malignant transformation and identify novel pathways that are uniquely relevant to tumorigenesis. Understanding the molecular underpinnings of cancer-associated alternative splicing isoforms will not only help to explain many fundamental hallmarks of cancer, but will also offer unprecedented opportunities to improve the efficacy of anti-cancer treatments. |
| format | Article |
| id | doaj-art-981f40d50c634c97b0e5c2ef4599a970 |
| institution | OA Journals |
| issn | 1687-8876 1687-8884 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Cell Biology |
| spelling | doaj-art-981f40d50c634c97b0e5c2ef4599a9702025-08-20T02:10:08ZengWileyInternational Journal of Cell Biology1687-88761687-88842013-01-01201310.1155/2013/962038962038Oncogenic Alternative Splicing Switches: Role in Cancer Progression and Prospects for TherapySerena Bonomi0Stefania Gallo1Morena Catillo2Daniela Pignataro3Giuseppe Biamonti4Claudia Ghigna5Istituto di Genetica Molecolare, Consiglio Nazionale delle Ricerche (IGM-CNR), Via Abbiategrasso 207, 27100 Pavia, ItalyIstituto di Genetica Molecolare, Consiglio Nazionale delle Ricerche (IGM-CNR), Via Abbiategrasso 207, 27100 Pavia, ItalyIstituto di Genetica Molecolare, Consiglio Nazionale delle Ricerche (IGM-CNR), Via Abbiategrasso 207, 27100 Pavia, ItalyIstituto di Genetica Molecolare, Consiglio Nazionale delle Ricerche (IGM-CNR), Via Abbiategrasso 207, 27100 Pavia, ItalyIstituto di Genetica Molecolare, Consiglio Nazionale delle Ricerche (IGM-CNR), Via Abbiategrasso 207, 27100 Pavia, ItalyIstituto di Genetica Molecolare, Consiglio Nazionale delle Ricerche (IGM-CNR), Via Abbiategrasso 207, 27100 Pavia, ItalyAlterations in the abundance or activities of alternative splicing regulators generate alternatively spliced variants that contribute to multiple aspects of tumor establishment, progression and resistance to therapeutic treatments. Notably, many cancer-associated genes are regulated through alternative splicing suggesting a significant role of this post-transcriptional regulatory mechanism in the production of oncogenes and tumor suppressors. Thus, the study of alternative splicing in cancer might provide a better understanding of the malignant transformation and identify novel pathways that are uniquely relevant to tumorigenesis. Understanding the molecular underpinnings of cancer-associated alternative splicing isoforms will not only help to explain many fundamental hallmarks of cancer, but will also offer unprecedented opportunities to improve the efficacy of anti-cancer treatments.http://dx.doi.org/10.1155/2013/962038 |
| spellingShingle | Serena Bonomi Stefania Gallo Morena Catillo Daniela Pignataro Giuseppe Biamonti Claudia Ghigna Oncogenic Alternative Splicing Switches: Role in Cancer Progression and Prospects for Therapy International Journal of Cell Biology |
| title | Oncogenic Alternative Splicing Switches: Role in Cancer Progression and Prospects for Therapy |
| title_full | Oncogenic Alternative Splicing Switches: Role in Cancer Progression and Prospects for Therapy |
| title_fullStr | Oncogenic Alternative Splicing Switches: Role in Cancer Progression and Prospects for Therapy |
| title_full_unstemmed | Oncogenic Alternative Splicing Switches: Role in Cancer Progression and Prospects for Therapy |
| title_short | Oncogenic Alternative Splicing Switches: Role in Cancer Progression and Prospects for Therapy |
| title_sort | oncogenic alternative splicing switches role in cancer progression and prospects for therapy |
| url | http://dx.doi.org/10.1155/2013/962038 |
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