The <i>in vitro</i> neuroprotective activity of analogues of N-terminus substituted glyprolines
In this work investigated the neuroprotective activity of analogues of substituted glyproline GZK-111 at the N-terminus in vitro. Oxidative stress caused by H2O2 (1.5 mM) led to significant decrease in the hippocampal cells HT-22 viability. The ethyl ester N-phenypropionyl-glycyl-proline (GZK-45) wa...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
LLC “Publisher OKI”
2020-12-01
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| Series: | Фармакокинетика и Фармакодинамика |
| Subjects: | |
| Online Access: | https://www.pharmacokinetica.ru/jour/article/view/242 |
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| Summary: | In this work investigated the neuroprotective activity of analogues of substituted glyproline GZK-111 at the N-terminus in vitro. Oxidative stress caused by H2O2 (1.5 mM) led to significant decrease in the hippocampal cells HT-22 viability. The ethyl ester N-phenypropionyl-glycyl-proline (GZK-45) was effective at the concentrations up to 10–6 M in both experimental schemes. The compounds with N-acethyl (GZK-49) and N-capronoyl (GZK-46) fragments did not protective effect in both experimental schemes. GZK-45 also had protective effect in the 6-hydroxydopamine induced damage of SH-SY5Y neuroblastoma cells. |
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| ISSN: | 2587-7836 2686-8830 |